Coronary Aneurysm (Aneurysm, Coronary)

Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.

Also Known As:

Networked: 297 relevant articles (9 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease)
2.	Aneurysm (Aneurysms)
3.	Fever (Fevers)
4.	Anterior Wall Myocardial Infarction
5.	Thrombosis (Thrombus)

Experts

1.	Colombo, Antonio: 6 articles (01/2006 - 03/2002)
2.	Ogawa, Shunichi: 5 articles (12/2013 - 08/2004)
3.	Matsuishi, Toyojiro: 4 articles (05/2011 - 02/2008)
4.	Nakamura, Yosikazu: 3 articles (12/2013 - 02/2004)
5.	Rowley, Anne H: 3 articles (01/2012 - 04/2005)
6.	Shulman, Stanford T: 3 articles (01/2012 - 04/2005)
7.	Suda, Kenji: 3 articles (05/2011 - 02/2008)
8.	Kudo, Yoshiyuki: 3 articles (05/2011 - 02/2008)
9.	Iakovou, Ioannis: 3 articles (05/2011 - 02/2005)
10.	Alfonso, Fernando: 3 articles (06/2009 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Coronary Aneurysm:

1.	Immunoglobulins (Immunoglobulin)IBA 04/22/2014 - "A surgical case of expanding bilateral coronary aneurysms regarded as immunoglobulin G4-related disease." 02/01/2014 - "Seventy-nine percent of the KD patients received intravenous immunoglobulin and 5% had persistent coronary aneurysm. " 05/01/2011 - "Two patients (18 %) without intravenous immunoglobulin developed coronary aneurysms. " 04/01/1993 - "Three of them not treated with immunoglobulins developed coronary aneurysms." 02/01/1987 - "[Trial of prevention of coronary aneurysm in Kawasaki's disease using plasma exchange or infusion of immunoglobulins]."
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/01/2008 - "The genotypic and allelic distributions did not differ between patients with and those without coronary aneurysms; however, patients with CRP +1444 CT/TT genotype compared with those with a CC genotype and patients with TNF-alpha -308 GA/AA genotype compared with those with a GG genotype had significantly greater carotid arterial stiffness and intima-media thickness. " 04/01/1993 - "In the 2nd week, the serum levels of sIL-2R and TNF alpha were significantly higher in the patients with than in those without coronary aneurysm (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/2011 - "The Mexican population has a distinct capacity for the expression of tumor necrosis factor (TNF), a cytokine that plays a cardinal role in Kawasaki disease (KD), particularly in those who develop coronary aneurysms. " 09/01/2008 - "We analyzed the CRP +1444 C-->T and TNF-alpha -308 G-->A polymorphisms in 167 patients aged 8.9 +/- 4.1 years with a history of Kawasaki disease (73 with and 94 without coronary aneurysms) and 124 healthy control subjects. " 10/01/2011 - "Tumor necrosis factor -308 and lymphotoxin +252 polymorphisms in Mexican children with Kawasaki disease and coronary aneurysms."
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/2009 - "However the addition of corticosteroids to standard therapy did not decrease the incidence of coronary aneurysms or adverse events." 10/01/2005 - "The objective of this study was to identify clinical trials that compared the rate of coronary aneurysm formation after initial therapy with corticosteroids or an appropriate control and to determine the overall efficacy of corticosteroid therapy for the initial treatment of Kawasaki disease. " 08/01/2006 - "The inclusion of corticosteroids in treatment regimens for Kawasaki disease: effect on coronary aneurysms." 11/01/2010 - "We present a 5 months-old infant with refractory Kawasaki disease who developed coronary aneurysms despite two immunoglobulin doses and three intravenous pulses-doses of corticosteroids. " 10/01/2005 - "The inclusion of corticosteroids in aspirin-containing regimens for the initial treatment of Kawasaki disease reduces the incidence of coronary aneurysms."
4.	Intravenous Immunoglobulins (IVIG)FDA Link 08/01/2014 - "Use of intravenous immunoglobulins, however, has led to significant reduction in incidence of coronary aneurysms. " 07/15/2015 - "An NLR 2 days after IVIG that exceeded 1 was predictive of coronary aneurysm development and IVIG resistance." 07/15/2015 - "Multivariate analysis revealed that the NLR 2 days after IVIG independently predicted coronary aneurysm development (p = 0.03) and IVIG resistance (p <0.001). " 06/01/2015 - "Although IVIG use improves the initial severity of coronary lesions, it does not further modify the long-term fate of coronary aneurysms." 05/01/2014 - "Storage of IVIG in acidic solution might be correlated with a higher rate of coronary aneurysm (two reports). "
5.	infliximab (Remicade)FDA Link 09/01/2014 - "The efficacy of Remicade for reducing the fever duration, CRP, WBC counts was promising, but reduction of the incidence of coronary aneurysm was not confirmed. " 11/01/2010 - "[Refractory Kawasaki disease with coronary aneurysms treated with infliximab]."
6.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 05/06/1989 - "Several therapeutic trials have confirmed the effectiveness of gammaglobulins (400 mg/kg.day) and acetylsalicylic acid in preventing the formation of coronary aneurysms. " 07/01/1992 - "At that time, a coronary aneurysm was detected by echocardiogram and aspirin had started to administer. " 12/01/1990 - "Treatment consists of gammaglobulins and aspirin in high doses; when administered at an early stage, it prevents the formation of coronary aneurysms." 12/01/1987 - "Protocol of management consisted of high-dose aspirin (100 mg/kg/d) until afebrile, and then 81 mg every day until free of coronary aneurysm. " 08/01/1993 - "Among the 14 patients treated with aspirin alone, large coronary aneurysms were noted in four, moderate aneurysms in three and transient aneurysms in one. "
7.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 01/01/2011 - "Follow-up CAG performed 3-6 months after the procedure revealed no restenosis in all three cases, but a new coronary aneurysm still remained in case 3. Although case 1 and case 2 had no obvious history of KD, the vessel wall morphology from IVUS closely resembled the coronary sequelae after KD, suggesting that they might have antecedent incomplete KD. " 04/01/2007 - "This was associated with marked positive vessel remodeling and coronary aneurysm formation involving the stented segment of the coronary artery. " 12/02/2003 - "Vessel dimensions and area of ISA did not change over time, except for 1 coronary aneurysm that became apparent. " 01/01/2002 - "Echocardiograms were reviewed for coronary aneurysms (lumen diameter 1.5 times that of the adjacent vessel). " 04/01/1996 - "Left main coronary aneurysm and severe three-vessel disease with sparing of an isolated conus artery."
8.	gamma-Globulins (gamma-Globulin)IBA 11/01/1999 - "The introduction of high-dose intravenous gamma-globulin (IVGG) was an epoch in this field and IVGG is now a standard therapy with the incidence of persistent coronary aneurysms 1.9% in children with the disease receiving IVGG. " 09/01/1999 - "To prevent the development of cardiac sequelae, in particular giant coronary aneurysms, gamma-globulin therapy should be started as soon as possible and be completed within 2 days." 01/01/1989 - "These results suggest that even with delay in the time of start of prophylactic gamma-globulin therapy, it still can reduce the formation of giant coronary aneurysm." 06/01/1991 - "The results of a multicenter, randomized trial on the effect of intravenous administration of gamma globulin (IVGG) plus aspirin versus aspirin alone upon coronary aneurysm formation show a decrease in coronary aneurysm formation from the usual 20%-30% to 3%. " 03/01/2003 - "Unless treated promptly with high-dose intravenous gamma globulin and aspirin, patients frequently develop coronary aneurysms. "
9.	Interleukin-6 (Interleukin 6)IBA 03/01/1993 - "These results suggest that serum IL-6 level is a useful factor for predicting formation of coronary aneurysm even within one week after onset of disease.(ABSTRACT TRUNCATED AT 250 WORDS)" 06/01/1992 - "Increased serum IL-6 level did not show any relation to development of coronary aneurysms and dilatation. " 04/01/1993 - "Within the 1st week, the serum levels of IL-6 and IL-8 were significantly higher in the patients with than in those without coronary aneurysm (P < 0.001). " 12/01/1992 - "The results suggest that elevated serum interleukin-6 and interleukin-8 levels during the first week of illness may be associated with a higher risk of coronary aneurysm formation." 04/01/1993 - "In this study, we measured serially the serum levels of cytokines including interleukin-6 (IL-6), IL-8, soluble IL-2 receptor (sIL-2R) and tumour necrosis factor alpha (TNF-alpha) in 60 patients with Kawasaki disease (KD) and evaluated the clinical significance of these cytokines in predicting coronary aneurysm formation. "
10.	CytokinesIBA 01/01/2005 - "No significant difference was observed in the genotypes and allelic frequencies of cytokines between patients with coronary aneurysm and without. " 06/01/1995 - "Thus, it is important for the prevention of coronary arteritis and the resultant coronary aneurysm to reduce the inflammatory cytokines in the plasma. " 04/01/1993 - "Cytokines predict coronary aneurysm formation in Kawasaki disease patients." 04/01/1993 - "In this study, we measured serially the serum levels of cytokines including interleukin-6 (IL-6), IL-8, soluble IL-2 receptor (sIL-2R) and tumour necrosis factor alpha (TNF-alpha) in 60 patients with Kawasaki disease (KD) and evaluated the clinical significance of these cytokines in predicting coronary aneurysm formation. "

Therapies and Procedures

1.	Stents 07/01/1999 - "High-pressure stent use without immediately visible vascular dissection by angiography may not be effective for prevention of coronary aneurysm development in a case such as this. " 05/01/2015 - "Managing bioabsorbable vascular scaffold failure: combined scaffold restenosis and late-acquired coronary aneurysm treated with self-expandable stent." 02/01/2015 - "Treatment for coronary aneurysms: twenty years of experience with covered stents." 12/01/2014 - "Coronary aneurysm closure with pericardial covered stent evaluated with optical coherence tomography." 09/01/2014 - "NIRS-IVUS-guided implantation of pericardium-covered stents in a giant coronary aneurysm."
2.	Drug-Eluting Stents 10/30/2008 - "Spontaneous resolution of potentially drug eluting stent-related coronary aneurysms is documented. " 10/30/2008 - "Spontaneous resolution of multiple coronary aneurysms complicating drug eluting stent implantation." 04/15/2013 - "Nine patients were enrolled in this study, including patients with coronary artery perforations, original coronary aneurysms, and acquired coronary aneurysms after drug-eluting stent implantation. " 06/02/2009 - "This study sought to assess clinical, angiographic, and intravascular ultrasound (IVUS) findings in patients developing coronary aneurysms (CANs) after drug-eluting stent (DES) implantation. " 08/01/2011 - "Clinical presentation and outcomes of drug-eluting stent-associated coronary aneurysms."
3.	Angioplasty (Angioplasty, Transluminal) 08/01/2008 - "Patch closure of the coronary aneurysm and patch angioplasty of the left main coronary artery were performed. " 08/01/2008 - "[Patch closure and patch angioplasty for a coronary aneurysm after percutaneous coronary intervention]." 03/01/2008 - "Coronary aneurysm formation after primary coronary angioplasty." 02/01/2004 - "Coronary aneurysms were not evident in either patient at the time of angioplasty. " 06/01/1994 - "Serial arteriographic findings in a patient with development of an unusually large coronary aneurysm after angioplasty."
4.	Plasma Exchange 02/01/1987 - "[Trial of prevention of coronary aneurysm in Kawasaki's disease using plasma exchange or infusion of immunoglobulins]."
5.	Transplants (Transplant) 01/01/2012 - "Specimens from 32 autopsies, 8 cardiac transplants, and an excised coronary aneurysm were studied by light (n=41) and transmission electron microscopy (n=7). " 10/01/2011 - "Multiple giant coronary aneurysms--exclusion by vein graft interposition." 09/01/2009 - "Coronary aneurysms in a patient with bypass grafts." 02/01/2003 - "We placed coronary bypass grafts onto left anterior descending, diagonal and obtuse marginal branches, and excluded the coronary aneurysm by ligating both its inflow and outflow. " 10/01/2000 - "Interposition vein graft for giant coronary aneurysm repair."