Corneal Diseases (Corneal Disease)

01/01/2014 - "Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. "
01/01/2009 - "Special attention is needed when prescribing steroid eye drops to treat corneal disease especially postoperatively. "
01/01/2003 - "Although the traditional approach to treating dry eye is to hydrate and lubricate the ocular surface with artificial tears, symptoms and/or sight-threatening corneal disease may persist in some patients on such aqueous enhancement therapies. "
10/01/2012 - "Our results indicate that EGF eye drops appear to be a very effective treatment of acute heterogeneous corneal diseases, without significant adverse effects, with a 86.8% clinical efficacy reported by authors, a 98% (P<0.05) probabilistic expected efficacy, and 51.3 (17.4-148.7 confidence interval 95%; P<0.05) odds ratio EGF/vehicle. "
10/01/2009 - "Thirty eyes of 27 patients with progressive corneal neovascularisation (not responding to conventional anti-inflammatory treatment) due to different underlying corneal diseases received topical bevacizumab (Avastin) eye drops (5 mg/ml Bevacizumab) for 0.5-12 months (five times/day on average). "

04/01/1998 - "Local administration of IL-10 also dramatically reduced the number of T cells and neutrophils migrating into the cornea and suppressed the severity of corneal disease. "
01/01/2001 - "Similarly, mice with a disrupted IL-10 gene developed more severe corneal disease than wild-type controls. "
01/01/2001 - "We investigated whether IL-10 produced endogenously would influence the development of HSV-1-induced acute corneal disease. "
04/01/1998 - "We conclude that local IL-10 administration can suppress chemokine synthesis, thereby ameliorating corneal disease. "
01/01/2005 - "Interleukin-10 (IL-10) ameliorates corneal disease in a mouse model of recurrent herpetic keratitis."

11/01/2011 - "SHG imaging of the structure of collagen lamellae in normal and diseased corneas thus has the potential to provide insight both into the mechanism for maintenance of corneal curvature as well as into the pathophysiology of corneal diseases."
03/01/2010 - "Collagen cross-linking: a new treatment paradigm in corneal disease - a review."
01/01/2011 - "The aim of our study was to evaluate the efficacy of glaucoma surgery with collagen implant in patients with RG associated with severe corneal disease. "
01/01/2015 - "Keratoconus is a slowly progressive, noninflammatory ectatic corneal disease characterized by changes in corneal collagen structure and organization. "
03/01/2010 - "The aim of this review is to summarize the theoretical basis and risks of corneal collagen cross-linking, along with the available evidence for its use in keratoconus and other corneal disease states."

04/01/2011 - "In these studies, tacrolimus has shown efficacy in corneal graft rejection, inflammatory conjunctival and corneal diseases, uveitis, and graft-versus-host disease. "
05/01/2013 - "The administration of topical tacrolimus (FK506) eye drops or ointment is effective in treating certain immunologic corneal diseases and in the prevention of rejection of high-risk corneal grafts. "

01/01/1987 - "Twenty nine published clinical trials with acyclovir (ACV) ophthalmic ointment in the treatment of herpes simplex virus (HSV) corneal disease have been reviewed in which ACV has been demonstrated to be effective in the treatment of simple dendritic ulcers, geographic ulcers, deep corneal HSV infections and ocular disease associated with herpes zoster (VZV) infection affecting the ophthalmic division of the trigeminal nerve. "
12/01/1983 - "Chronic oral administration of acyclovir or bromovinyl deoxyuridine to rabbits did not prevent recurrence of virus shedding or clinical corneal disease, nor did it alter the clinical course of recurrences of ocular herpetic disease or result in the appearance of resistant virus in tears."

03/01/2001 - "Cytokines play an important role in the pathogenesis of various corneal diseases and during corneal graft rejection. "
09/01/1997 - "The results demonstrate that in vitro activation of keratocytes and BCE cells by LPS and cytokines induces NOS-2 expression and release of large amounts of NO. The high amounts of NO could be involved in inflammatory corneal diseases in vivo."
03/01/2001 - "This review focuses on the effects of several cytokines in corneal immunopathology, including the type of the corneal immune response, angiogenesis, chemotaxis, apoptosis, wound healing, corneal disease, and transplantation. "
07/01/2011 - "The results indicated that blockade of TREM-1 reduced the severity of corneal disease, polymorphonuclear neutrophil infiltration, Th1/proinflammatory cytokine expression and Toll-like receptor (TLR) activation but enhanced the production of Th2 cytokines, murine β-defensin 2 (mBD2), single Ig interleukin-1R-related molecule (SIGIRR), and ST2. "
01/01/2000 - "Abrogation of virus-induced corneal disease by anti-cytokine antibodies suggests that these cytokines play important roles in the pathogenesis of recurrent disease. "

09/01/2006 - "To determine the safety and efficacy of the use of intraoperative mitomycin C (MMC) during phototherapeutic keratectomy (PTK) for anterior corneal disease. "
06/01/1999 - "Complications included transient flat anterior chamber and corneal epithelial defects, each of which occurred in a single eye in group 1, and progressive cataract, which occurred in a single eye in group 2. Mitomycin-C was found to be safe and efficient in the present series, controlling IOP in 10 of 11 eyes (91%) with coexisting corneal disease and glaucoma. "
06/01/1999 - "To evaluate the efficacy and safety of application of mitomycin-C (MMC) in combined and separate trabeculectomy and penetrating keratoplasty for the treatment of coexisting corneal disease and glaucoma. "
11/01/1996 - "Combined penetrating keratoplasty and trabeculectomy with mitomycin-C should be considered for selected patients with uncontrolled glaucoma and corneal disease who have sufficient conjunctiva for a filtering procedure."
11/01/1996 - "Management of coexisting corneal disease and glaucoma by combined penetrating keratoplasty and trabeculectomy with mitomycin-C."

01/01/1994 - "During corneal disease the concentration of EGF in tear fluid considerably decreases to levels even lower than those found during short time stimulation of reflex tearing. "
04/01/1992 - "[EGF in therapy of corneal diseases. "
10/01/2012 - "Our results indicate that EGF eye drops appear to be a very effective treatment of acute heterogeneous corneal diseases, without significant adverse effects, with a 86.8% clinical efficacy reported by authors, a 98% (P<0.05) probabilistic expected efficacy, and 51.3 (17.4-148.7 confidence interval 95%; P<0.05) odds ratio EGF/vehicle. "

01/01/2013 - "Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in decreasing the risk of cystoid macular edema (CME) in high-risk eyes, but must be used with caution in patients with prior corneal disease. "
05/01/2005 - "The structured search strategy included a RCT filter and the terms "cornea," "wounds and injuries," "trauma," "corneal diseases," "eye injuries," "anti-inflammatory agents, nonsteroidal" and specific trade names of topical NSAIDs. "
02/01/2006 - "These findings, together with similar previous reports concerning diclofenac sodium and ketorolac, suggest that careful observation is required when using topical NSAIDs in the treatment of corneal disease."

10/01/2009 - "To evaluate the short- and long-term in vivo safety and efficacy of topical bevacizumab (Avastin) application for treatment of corneal neovascularization secondary to a variety of corneal diseases. "
10/01/2009 - "Off-label topical bevacizumab therapy against corneal neovascularization secondary to different corneal diseases was generally well-tolerated for up to 12 months. "
10/01/2009 - "Thirty eyes of 27 patients with progressive corneal neovascularisation (not responding to conventional anti-inflammatory treatment) due to different underlying corneal diseases received topical bevacizumab (Avastin) eye drops (5 mg/ml Bevacizumab) for 0.5-12 months (five times/day on average). "
08/01/2012 - "Sixteen eyes of 16 patients with mature corneal neovascularization (NV) due to different underlying corneal diseases underwent fine-needle feeder vessel coagulation by diathermy and were treated postoperatively for up to 4 weeks with topical bevacizumab eye drops (containing 5 mg/mL bevacizumab) 5 times a day. "

03/01/2014 - "When preventive strategies have failed, corneal transplantation is the most effective treatment for advanced corneal disease. "
03/01/2010 - "Although Descemet stripping automated endothelial keratoplasty (DSAEK) was demonstrated to be effective for the treatment of endothelial corneal diseases, a variable hyperopic shift has been measured as a common occurrence postoperatively. "
01/01/2013 - "Regenerative medicine for the cornea provides a novel treatment strategy for patients with corneal diseases instead of conventional keratoplasty. "
03/01/1989 - "Corneal transplantation offers the cure for those with blinding corneal disease. "
02/01/2014 - "Our objective was to study the outcome of femtosecond-assisted lamellar keratoplasty (FSLK) in stromal corneal diseases. "

08/01/1989 - "In this study we summarized the visual results in five corneal diseases with a low rate of graft failure. "
05/01/2015 - "As many patients with severe corneal disease are not even considered as candidates for a human graft due to their high risk of rejection, it is essential to find ways to reduce the chance of rejection. "
02/01/2015 - "First, we will describe common experimentally used corneal lymphangiogenesis models and will recapitulate recent findings regarding the involvement of lymphatic vessels in corneal diseases and transplant immunology. "
01/01/2015 - "Penetrating corneal transplant (PKP) surgery has been performed for centuries as the procedure of choice to restore vision in cases of advanced corneal disease. "
10/01/2014 - "Eye donation for corneal transplant holds the key for visual restoration from corneal diseases. "

09/01/2013 - "The purpose of the present study was to evaluate the preoperative and postoperative results of femtosecond laser-assisted implantation of INTACS in ectatic corneal diseases. "
07/01/2010 - "Continued studies using this ultrafast laser may continue to yield new and exciting possibilities in the treatment of corneal disease."
01/01/2015 - "A non-comparative case series of 14 eyes (13 patients) with various stromal corneal diseases underwent ALK with a femtosecond laser. "
08/01/2003 - "The use of lasers for small-animal corneal disease is fairly limited due to several factors. "
08/01/2003 - "Laser applications for corneal disease."

06/01/2013 - "The global reputation of Dr. Khodadoust is rooted in his extensive studies on corneal diseases and transplantation biology. "
03/01/2014 - "In conclusion, we demonstrate that the treatment of human corneas in eye banks before transplantation is a new approach to address the unmet clinical needs in corneal diseases. "
02/01/2013 - "Keratocyte progenitor cell transplantation: A novel therapeutic strategy for corneal disease."
05/01/2012 - "These observations suggest that corneal intrastromal transplantation of BM-MSC may be an effective treatment regimen for corneal diseases involving dysfunction of keratocytes."
07/01/2009 - "Amniotic membrane (AM) transplantation is an excellent treatment modality to promote corneal wound healing and treat corneal diseases. "

07/01/2011 - "Is this corneal disease the indication of excimer laser keratectomy? "
02/01/2003 - "This paper reviews advances in excimer laser treatment of corneal disease."
05/01/2002 - "The Corneal Diseases and Excimer Laser Research Unit, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland. "
11/01/2001 - "Corneal Diseases and Excimer Laser Research Unit, University of Dundee, Dundee, Scotland. "
04/01/2001 - "Corneal Diseases and Excimer Laser Research Unit, Department of Ophthalmology, University of Dundee, Dundee, United Kingdom. "