Coproporphyrinogen Oxidase (Coproporphyrinogen III Oxidases)

An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.

Also Known As:

Networked: 66 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Anderson, Karl E: 3 articles (01/2022 - 01/2006)
2.	Desnick, Robert J: 3 articles (11/2019 - 02/2011)
3.	Deybach, Jean-Charles: 3 articles (11/2019 - 01/2002)
4.	Puy, Hervé: 3 articles (11/2019 - 01/2002)
5.	Anand, Sanjay: 3 articles (01/2018 - 09/2011)
6.	Maytin, Edward V: 3 articles (01/2018 - 09/2011)
7.	Taketani, Shigeru: 3 articles (12/2013 - 01/2006)
8.	Higuchi, Keiichi: 2 articles (01/2022 - 07/2013)
9.	Mori, Masayuki: 2 articles (01/2022 - 07/2013)
10.	Chen, Brenden: 2 articles (11/2019 - 11/2019)

Related Diseases

1.	Hereditary Coproporphyria (Coproporphyrinogen Oxidase Deficiency) 06/01/2023 - "In humans, mutations in the coproporphyrinogen oxidase (CPOX) gene can result in hereditary coproporphyria (HCP), characterized by high levels of coproporphyrin excretion in the urine and feces, as well as acute neurovisceral and chronic cutaneous manifestations. " 02/01/2002 - "Her mother and both sisters could be verified as heterozygous gene carriers of hereditary coproporphyria by their urinary and fecal excretion parameters and because of reduced coproporphyrinogen oxidase activity up to 50%. " 01/15/2002 - "The mother and both sisters were recognized as heterozygous gene carriers of hereditary coproporphyria in the latent phase by enhanced coproporphyrin with isomer I/III inversion in feces and decrease of the coproporphyrinogen oxidase activity to about 50%. " 01/01/2002 - "Two novel mutations and coexistence of the 991C>T and the 1339C>T mutation on a single allele in the coproporphyrinogen oxidase gene in Swedish patients with hereditary coproporphyria." 11/01/2000 - "The knowledge of at least 21 different mutations and several polymorphisms in the coproporphyrinogen oxidase (CPO) gene demonstrates that the molecular basis of hereditary coproporphyria is heterogeneous. "
2.	Porphyrias (Porphyria) 04/01/1995 - "Genetic defects of coproporphyrinogen oxidase (CPO) lead to hereditary coproporphyria, an inherited autosomal dominant porphyria. " 01/01/1989 - "Studies were conducted on the etiology of trace metal-induced porphyria in rats, with particular emphasis on the action of metals on hepatic and renal coproporphyrinogen oxidase. " 01/01/1989 - "Studies on the etiology of trace metal-induced porphyria: effects of porphyrinogenic metals on coproporphyrinogen oxidase in rat liver and kidney." 11/01/2011 - "Digenic inheritance of mutations in the coproporphyrinogen oxidase and protoporphyrinogen oxidase genes in a unique type of porphyria." 01/01/2006 - "Dual gene defects involving delta-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient."
3.	Coproporphyria 08/10/2000 - "The present paper describes a sensitive, specific and rapid fluorometric high performance liquid chromatography method to measure coproporphyrinogen oxidase, which could be applied to the diagnosis of human coproporphyria, and which is also suitable for the study of lead and other metal poisoning that produce alterations in this enzymatic activity." 04/12/1994 - "Coproporphyrinogen oxidase (EC 1.3.3.3) catalyzes the sixth step in the heme biosynthetic pathway, the oxidation of coproporphyrinogen III to protoporphyrinogen IX. The activity of this enzyme is deficient in the disease hereditary coproporphyria. "
4.	Poisoning 08/10/2000 - "The present paper describes a sensitive, specific and rapid fluorometric high performance liquid chromatography method to measure coproporphyrinogen oxidase, which could be applied to the diagnosis of human coproporphyria, and which is also suitable for the study of lead and other metal poisoning that produce alterations in this enzymatic activity."
5.	Harderoporphyria 06/01/2019 - "Harderoporphyria: Case of lifelong photosensitivity associated with compound heterozygous coproporphyrinogen oxidase (CPOX) mutations." 02/01/2011 - "Harderoporphyria due to homozygosity for coproporphyrinogen oxidase missense mutation H327R." 05/01/2001 - "Our findings add substantially to knowledge of the molecular epidemiology of HCP, show that single copies of CPO mutations that are known or predicted to cause "homozygous" HCP or harderoporphyria can produce typical HCP in adults, and demonstrate that the severity of the phenotype does not correlate with the degree of inactivation by mutation of coproporphyrinogen oxidase." 09/01/1983 - "We suggest naming this variant of coproporphyrinogen oxidase defect "harderoporphyria."" 01/01/2017 - "Genetic mutation of the coproporphyrinogen oxidase (CPOX) gene causes either hereditary coproporphyria (HCP) or harderoporphyria. "

Related Drugs and Biologics

1.	Metals
2.	Proteins (Proteins, Gene)
3.	Enzymes
4.	Heme (Haem)
5.	Protoporphyrinogen Oxidase (Protox)
6.	Porphyrins
7.	Ferrochelatase (Heme Synthetase)
8.	Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)
9.	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)
10.	protoporphyrin IX

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)