Copper

12/01/1978 - "Urinary copper excretion was significantly elevated in response to 30 mg/kg of DMS, suggesting that the drug might also be useful for the treatment of Wilson's disease."
02/01/2007 - "Chelating agent is the mainstay of treatment in Wilson's disease, which is an inherited disorder of hepatic copper metabolism. "
03/01/2005 - "[Genetic disorders of copper transport--diagnosis and new treatment for the patients of Wilson's disease]."
06/01/1998 - "An improved method for the study of copper metabolism in Wilson's disease, using a stable, rather than radioactive, copper isotope (65Cu) has recently been described. "
11/01/1996 - "Although results of neurologic examination, speech pathology examination, and 24-h urine copper level analysis in symptomatic Wilson's disease patients improved during the study period, KF ring regression did not correlate with the improvement in these clinical parameters (p > 0.05). "

09/01/2002 - "Significant reduction in size of the primary tumor was observed in mice rendered copper deficient. "
05/01/2000 - "(2) The decrease of MT in tissue of tumor could be beneficial for copper to exert full effect in killing tumor cell."
01/01/2013 - "Decreasing bioavailable copper has been used as an anti-angiogenic and anti-cancer strategy with promising results. "
12/01/2002 - "Copper levels lowered into an antiangiogenic window by TM have shown efficacy against cancer in a variety of animal models as well as in patients. "
07/07/2015 - "Although the contrast enhancement effect of the copper sulfide NPs is proportional to particle size, the in vivo studies revealed that copper sulfide NPs smaller than 5 nm presented higher tumor imaging performance, especially at the tumor boundary site, which was further discussed in combination with the pharmacokinetic behaviors of differently sized particles. "

06/30/2006 - "Copper oxide wire particles (COWP; 2g) have proven effective in decreasing GIN infection in lambs. "
09/01/2000 - "As there are very few other anthelmintic options during the lactating period, we have evaluated the efficacy of copper oxide needles (CON, Copinox, Bayer, UK) in both experimental and natural infections in goats. "
09/15/2012 - "Here, we tested whether copper inhibits oHSV infection and replication and whether copper chelation would augment therapeutic efficacy of oHSV. "
04/01/2002 - "To assess the efficacy of copper oxide wire particles (COWP) for the control of H contortus infections in grazing sheep. "
07/31/2015 - "Several independent studies have recently converged upon the conclusion that the human bacterial pathogen Mycobacterium tuberculosis encounters copper during infections. "

11/01/2013 - "Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms."
12/01/1999 - "Our findings suggest that copper or copper agonists might be useful tools to discover novel targets for anti-Alzheimer drugs and may prove beneficial for the prevention of Alzheimer's disease."
02/01/2015 - "An overview of various mammalian models to study chronic copper intoxication associated Alzheimer's disease like pathology."
01/01/2015 - "The main objective of this review is to provide some of the most relevant evidence gleaned from recent studies conducted on animal models and humans, and to discuss the evidence as it pertains to a new concept: Aberrant copper metabolism, which appears to have a genetic basis, is a modifiable risk factor accelerating Alzheimer's disease and initiation/progression of cognitive deficits in a percentage of susceptible persons. "
10/01/2014 - "Copper subtype of Alzheimer's disease (AD): meta-analyses, genetic studies and predictive value of non-ceruloplasmim copper in mild cognitive impairment conversion to full AD."

07/01/1955 - "[Protection against acute copper poisoning using chelating substances]."
05/01/2012 - "Our goal in this study was to assess relationship between copper poisoning and semen quality parameters. "
03/01/2012 - "This study was planned to identify common presentations and complications of copper sulphate poisoning, and biochemical parameters that predict outcomes in these patients. "
09/01/1999 - "Induction of chronic copper poisoning in ten boma-confined impala was attempted in a randomized, single dose, parallel designed, titration study using five increasing oral doses, ranging between 125 mg/kg to 1000 mg/kg, of copper oxide needles. "
09/01/1999 - "The results of this study confirmed the occurrence of chronic copper poisoning in impala and indicated an inverse relationship in extent of impala faecal copper elimination and in tissue copper accumulation in impala and buffalo with distance from the copper smelter. "