Consciousness Disorders

Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.

Also Known As:

Networked: 107 relevant articles (5 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD)
2.	Hypercapnia
3.	Acidosis
4.	Jaundice
5.	Meningeal Carcinomatosis

Experts

1.	Lazić, Zorica: 2 articles (08/2011 - 01/2007)
2.	Gajović, Olgica: 2 articles (08/2011 - 01/2007)
3.	Canović, Predrag: 2 articles (08/2011 - 01/2007)
4.	Cruz, Angelo: 1 article (09/2015)
5.	Ersoy, Melike: 1 article (09/2015)
6.	Acharya, Soumyadipta: 1 article (09/2015)
7.	Yaroglu Kazanci, Selcen: 1 article (09/2015)
8.	Yildirim, Hamdi Murat: 1 article (09/2015)
9.	Sevketoglu, Esra: 1 article (09/2015)
10.	Bhalala, Utpal: 1 article (09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Consciousness Disorders:

1.	Naloxone (Narcan)FDA LinkGeneric 08/01/1990 - "We performed a retrospective review to investigate the safety of prehospital naloxone administration by paramedics as part of a protocol for all patients presenting with an acutely depressed level of consciousness (LOC). " 08/01/1986 - "[High doses of naloxone in consciousness disorders]." 02/01/2000 - "We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone."
2.	Ibuprofen (Motrin)FDA LinkGeneric 02/01/2000 - "We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone."
3.	CopperIBA 10/01/2003 - "Copper [24,000 microg] was removed by PE and CHDF over three days, which relieved the jaundice and the consciousness disorder. "
4.	3-aminobutyric acidIBA 08/01/1969 - "[Treatment of a consciousness disorder seizure specific to hepato-encephalopathy (Inose type)--trial use of gamma-hydroxy-beta-aminobutyric acid]."
5.	Creatine Kinase (Creatine Phosphokinase)IBA 02/01/1998 - "Neuroleptic malignant syndrome (NMS) is a rare disorder characterized by hyperthermia, elevated creatine phosphokinase, extrapyramidal effects, autonomic instability, altered level of consciousness and leukocytosis associated with neuroleptic and other psychotropic medications. " 06/01/1988 - "The signs and symptoms associated with the syndrome are hyperpyrexia, defined by body temperature greater than 38 degrees C; extreme muscle rigidity, with or without elevated creatine phosphokinase or hyperreflexia; and other symptoms such as altered level of consciousness and/or autonomic dysfunction as manifested by labile blood pressure, tachycardia, tachypnea, urinary or fecal incontinence, pallor, or diaphoresis. " 05/01/2005 - "The syndrome is characterized by fever, rigidity, autonomic instability, elevated creatine phosphokinase levels, and altered level of consciousness, which is usually precipitated by levodopa withdrawal. " 09/11/2004 - "Patients using neuroleptics who become ill with an altered level of consciousness, sweating and muscular rigidity, should at least have their blood tested for the level of creatine phosphokinase activity. "
6.	Blood Glucose (Blood Sugar)IBA 07/01/2015 - "The univariate analysis showed that there was no significant correlation between age, body temperature, consciousness disorders, blood glucose level and severe HFMD complicated with cardiopulmonary collapse. " 03/01/2005 - "Though his blood glucose level recovered normal, his consciousness disorder was suspended, and he showed remarkable hypercalcemia. " 01/01/1977 - "[Sensation fo bloating, a consciousness disorder, a loss of appetite, hepatomegaly, phlebectasia of the abdominal wall and ascites (gastrointestinal radiography, abdominal angiography and blood sugar levels): (liver cancer and hypoglycemic syndrome)]." 04/01/2001 - "Every sickness or consciousness disorder occurring in a diabetic patient treated with insulin should lead to perform a blood glucose measurement. "
7.	Antipsychotic Agents (Antipsychotics)IBA 10/01/1994 - "NMS was diagnosed in psychotic in-patients treated with neuroleptics if four features were present: diffuse severe rigidity, altered level of consciousness, hyperpyrexia and autonomic instability. " 12/01/1995 - "2. Neuroleptic malignant syndrome (NMS) is a rare but extremely severe adverse reaction to neuroleptic drugs characterized by extrapyramidal and autonomic symptoms, altered level of consciousness and abnormal laboratory findings. " 09/11/2004 - "Patients using neuroleptics who become ill with an altered level of consciousness, sweating and muscular rigidity, should at least have their blood tested for the level of creatine phosphokinase activity. "
8.	Cyclosporine (Ciclosporin)FDA LinkGeneric 08/01/1990 - "Tremor, seizures, and an altered level of consciousness developed in 1 patient as an apparent toxic reaction to cyclosporine treatment. " 07/10/1995 - "[A case of consciousness disorder, convulsion, meningeal stimulation, ocular motility disorder and ataxia induced by cyclosporin]."
9.	Valproic Acid (Valproate, Semisodium)FDA LinkGeneric 08/01/1989 - "We report the case of a 22-year-old man who presented with a depressed level of consciousness after ingesting valproic acid. " 01/01/2012 - "We present the case of a 36 year-old woman, with history of transient consciousness disorders with vegetative state, interpreted as epileptic crises and treated with valproate for two years. "
10.	Immunoglobulin M (IgM)IBA 03/01/2002 - "On univariate analysis, the following factors on admission were significantly associated with the combined end-point of death or a severe neurological deficit: depressed level of consciousness, elevated concentration of cerebrospinal fluid (CSF) protein, low levels of serum and CSF IgG antibody against Japanese encephalitis virus (JEV), low level of serum IgM antibody against JEV, and a serological response consistent with primary flavivirus infection. " 01/01/1989 - "Convulsions, hemiplegia and consciousness disorders pointed to a necrotizing viral or bacterial form of encephalitis, but the definitive diagnosis was based on the detection of IgM and IgG specific serum antibodies raised against Borrelia burgdorferi."

Therapies and Procedures

1.	Positive-Pressure Respiration (PEEP) 09/01/2005 - "A severely altered level of consciousness (ALC) has been considered a contraindication to noninvasive positive pressure ventilation (NPPV). " 01/01/2009 - "This study proved the value of non invasive positive pressure ventilation in hypercapnic exacerbation of COPD with improved in acidosis, hypercapnia, and altered level of consciousness. "
2.	Intravenous Infusions 08/01/2010 - "Discontinuation of VRCZ and drip infusion of normal saline improved the consciousness disorder, hyponatremia, and liver dysfunction. "
3.	Aftercare (After-Treatment) 03/01/2013 - "The leptomeningeal carcinomatosis findings on a head CT image and the patient's consciousness disorder improved after treatment. "
4.	Carotid Endarterectomy 11/01/2009 - "Patients with preoperative altered level of consciousness, carotid endarterectomy, or discharge within 24 h of surgery were excluded from the study. "
5.	Resuscitation 10/01/2014 - "The infant required intubation for severely depressed level of consciousness and aggressive fluid resuscitation for hemodynamic instability. " 07/01/2008 - "A 54-years-old patient coming from Guinea, who presented fever, diarrhoea, consciousness disorders and severe haemolytic anaemia, was admitted to resuscitation unit in France. " 04/01/1991 - "Many factors involved in the initial resuscitation of the multiply injured patient, such as altered level of consciousness, hemodynamic instability, or inexperience and diagnostic oversight, may lead to missed injuries. "