Complement C9 (Complement Component 9)

A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.

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Networked: 27 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, X: 1 article (11/2014)
2.	Gao, X: 1 article (11/2014)
3.	Zhou, J: 1 article (11/2014)
4.	Su, Z: 1 article (11/2014)
5.	Wüthrich, R P: 1 article (11/2014)
6.	Beyer, R P: 1 article (11/2014)
7.	Shi, M: 1 article (11/2014)
8.	Liu, Y: 1 article (11/2014)
9.	Zhang, J: 1 article (11/2014)
10.	Hu, H: 1 article (11/2014)

Related Diseases

1.	Infection 09/01/2011 - "Genetic analysis of complement component 9 (C9) polymorphisms with clearance of hepatitis B virus infection." 09/01/1982 - "Human complement C9 and factor B in the diagnosis of infections in infants." 09/01/2011 - "We conclude that variations in the complement component 9 gene are unlikely to influence clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence. " 09/01/2011 - "We hypothesized that genetic variations in the complement component 9 gene can influence the clearance of chronic hepatitis B virus infection, hepatocellular carcinoma occurrence, and onset age of hepatocellular carcinoma. "
2.	Chronic Hepatitis B 09/01/2011 - "In order to investigate the relationship of complement component 9 with chronic hepatitis B virus clearance and hepatocellular carcinoma occurrence, differences in SNP and haplotype frequency distributions were analyzed using logistic and multiple regression analyses with adjusted age and gender as covariates. " 09/01/2011 - "We conclude that variations in the complement component 9 gene are unlikely to influence clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence. " 09/01/2011 - "We hypothesized that genetic variations in the complement component 9 gene can influence the clearance of chronic hepatitis B virus infection, hepatocellular carcinoma occurrence, and onset age of hepatocellular carcinoma. "
3.	Hepatocellular Carcinoma (Hepatoma) 09/01/2011 - "In order to investigate the relationship of complement component 9 with chronic hepatitis B virus clearance and hepatocellular carcinoma occurrence, differences in SNP and haplotype frequency distributions were analyzed using logistic and multiple regression analyses with adjusted age and gender as covariates. " 09/01/2011 - "We conclude that variations in the complement component 9 gene are unlikely to influence clearance of chronic hepatitis B virus infection and hepatocellular carcinoma occurrence. " 09/01/2011 - "We hypothesized that genetic variations in the complement component 9 gene can influence the clearance of chronic hepatitis B virus infection, hepatocellular carcinoma occurrence, and onset age of hepatocellular carcinoma. "
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/1994 - "[A case of systemic lupus erythematosus in late component (C9) complement deficiency]." 04/01/1989 - "We describe the first case of systemic lupus erythematosus (SLE) showing the 9th component of complement (C9) deficiency. " 04/01/1989 - "Deficiency of the 9th component of complement (C9) in a patient with systemic lupus erythematosus." 04/01/1996 - "The metabolism of the ninth component of complement (C9) was studied in eight healthy subjects and nine patients with autoimmune disease, including seven with systemic lupus erythematosus (SLE) and one each with mesangial IgA nephropathy and mixed essential cryoglobulinaemia. "
5.	Necrosis 12/01/1984 - "We localized calcium and albumin as endogenous markers of extracellular fluid penetration and C3 and C9 complement components as markers of muscle fiber necrosis. " 01/01/2005 - "By immunohistochemistry, LN areas were positive for complement 9 (marker of necrosis) and negative for active caspase 3 (marker of irreversible apoptosis), nitrotyrosine residues (marker of oxidative stress), and Ki-67 (proliferation marker), thus confirming their necrotic rather than apoptotic nature. "

Related Drugs and Biologics

1.	Complement Factor B (Factor B)
2.	Complement System Proteins (Complement)
3.	Caspase 3 (Caspase-3)
4.	Troponin I
5.	P-Selectin
6.	Apolipoprotein A-I (Apolipoprotein A1)
7.	Zinc
8.	Vitamin A (Retinol)
9.	Proteins (Proteins, Gene)
10.	Iron