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Complement C8 (C8 Complement)

A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
Also Known As:
C8 Complement; Complement 8; Complement Component 8; Complement Component C8 alpha; Complement Component C8 alpha Chain; Complement Component C8 beta; Complement Component C8 beta Chain; Complement Component C8 gamma; Complement Component C8 gamma Chain; C8, Complement; Complement, C8; Component 8, Complement
Networked: 15 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Coolen, Jordy P M: 1 article (11/2021)
2. Henriet, Stefanie S V: 1 article (11/2021)
3. Langereis, Jeroen D: 1 article (11/2021)
4. de Groot, Ronald: 1 article (11/2021)
5. de Jonge, Marien I: 1 article (11/2021)
6. van den Broek, Bryan: 1 article (11/2021)
7. van der Flier, Michiel: 1 article (11/2021)
8. Afridi, Ruqayya: 1 article (01/2021)
9. Choe, Youngshik: 1 article (01/2021)
10. Han, Jin: 1 article (01/2021)

Related Diseases

1. Neuroinflammatory Diseases
2. Cognitive Dysfunction
3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
4. Dementia (Dementias)
5. Hemolysis

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Complement System Proteins (Complement)
3. Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)
4. Vaccines
5. Urea (Carbamide)
6. Properdin
7. Complement C9 (Complement Component 9)
8. Complement C5 (Complement 5)
9. Ceruloplasmin (Ferroxidase)
10. Carrier Proteins (Binding Protein)