Complement C7 (Complement 7)

A 93-kDa serum glycoprotein encoded by C7 gene. It is a polypeptide chain with 28 disulfide bridges. In the formation of MEMBRANE ATTACK COMPLEX; C7 is the next component to bind the C5b-6 complex forming a trimolecular complex C5b-7 which is lipophilic, resembles an integral membrane protein, and serves as an anchor for the late complement components, C8 and C9.

Also Known As:

Networked: 38 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kang, Hee Jung: 2 articles (03/2006 - 04/2005)
2.	Ki, Chang-Seok: 2 articles (03/2006 - 04/2005)
3.	Hu, Wenqian: 1 article (01/2022)
4.	Jia, Zhenxian: 1 article (01/2022)
5.	Wang, Siyue: 1 article (01/2022)
6.	Wu, Hongjiao: 1 article (01/2022)
7.	Xie, Yuning: 1 article (01/2022)
8.	Zhang, Xuemei: 1 article (01/2022)
9.	Zhang, Zhi: 1 article (01/2022)
10.	Choi, Beom Kyu: 1 article (12/2021)

Related Diseases

1.	Meningococcal Infections 12/01/1998 - "We report studies of an Irish family in which the index case had suffered recurrent meningococcal disease and was found to be deficient in the seventh component of complement (C7). " 03/01/2006 - "Complement C7 deficiency is associated with increased susceptibility to meningococcal infection. " 04/01/2005 - "Complement C7 deficiency is an autosomal recessive disorder well known to be associated with increased susceptibility to meningococcal infection and has mostly been reported in Caucasians. " 05/01/1991 - "Selective C7 complement deficiency causing recurrent meningococcal infection."
2.	Stomach Neoplasms (Stomach Cancer) 01/01/2022 - "This study aims to explore the relationship between complement component 7 (C7) polymorphisms and the risk of gastric cancer (GC). " 01/01/2022 - "Functional genetic variants in complement component 7 confer susceptibility to gastric cancer."
3.	Meningitis 08/15/2006 - "[Combined-heterozygous deficiency of complement C7 in a patient with recurrent meningitis]." 01/01/1992 - "[Recurrent Neisseria meningitidis meningitis associated with homozygote complement C7 fraction deficiency]." 08/01/1989 - "We describe an 11-year-old girl suffering from recurrent meningitis with a complete absence of the seventh component of complement (C7). " 06/01/1988 - "Three recent cases of inherited deficiency of the seventh component of complement (C7) associated with recurrent infectious meningitis are described. " 03/01/2013 - "A case of meningococcal sepsis and meningitis with complement 7 deficiency in a military trainee."
4.	Infections 04/02/2021 - "Disseminated gonococcal infection in a Japanese man with complement 7 deficiency with compound heterozygous variants: A case report." 03/01/2013 - "Complement component 7 (C7) deficiency leads to the loss of complement lytic function, and affected patients show increased susceptibility to encapsulated organisms infection, especially Neisseria meningitidis. " 01/01/1991 - "64 members of a large kindred with inherited deficiency of the seventh component of complement, C7, were studied for plasma levels of antigenetic and functional components of complement as well as for clinical manifestations of infections and autoimmune diseases. " 01/01/2012 - "Mice deficient in complement C7 and wild-type C57BL/6 mice were aerosol challenged with MTB Erdman and assessed for bacterial burden, histopathology, and lung cytokine responses at days 30 and 60 post-infection. "
5.	Complement Component 7 Deficiency 05/01/2007 - "Hereditary complement C7 deficiency in nine families: subtotal C7 deficiency revisited." 01/01/1999 - "Five new polymorphisms in the complement C7 gene and their association with C7 deficiency." 01/01/2023 - "Recurrent Neisseria meningitidis is frequently associated with terminal complement protein deficiency, including Complement component 7. This report discusses the first case of C7 deficiency in Qatar. " 03/01/2013 - "Complement component 7 (C7) deficiency leads to the loss of complement lytic function, and affected patients show increased susceptibility to encapsulated organisms infection, especially Neisseria meningitidis. "

Related Drugs and Biologics

1.	Complement System Proteins (Complement)
2.	Biomarkers (Surrogate Marker)
3.	Proteins (Proteins, Gene)
4.	Cytokines
5.	Suspensions
6.	Complement Factor B (Factor B)
7.	Nucleotides
8.	Androgens
9.	Aerosols
10.	cesium chloride (CsCl)