Complement C6 (Complement 6)

A 105-kDa serum glycoprotein with significant homology to the other late complement components, C7-C9. It is a polypeptide chain cross-linked by 32 disulfide bonds. C6 is the next complement component to bind to the membrane-bound COMPLEMENT C5B in the assembly of MEMBRANE ATTACK COMPLEX. It is encoded by gene C6.

Also Known As:

Networked: 32 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Atsumi, Tatsuya: 1 article (08/2022)
2.	Fujimura, Miki: 1 article (08/2022)
3.	Fukumori, Yasuo: 1 article (08/2022)
4.	Hatase, Masanao: 1 article (08/2022)
5.	Inoue, Norimitsu: 1 article (08/2022)
6.	Kato, Masaru: 1 article (08/2022)
7.	Kudo, Yuki: 1 article (08/2022)
8.	Sugiyama, Taku: 1 article (08/2022)
9.	Takeyama, Shuhei: 1 article (08/2022)
10.	Tsuchida, Naohisa: 1 article (08/2022)

Related Diseases

1.	Meningococcal Meningitis 05/01/1990 - "Forty South African patients with homozygous deficiency of the sixth component of complement (C6) have been identified in an area where group B meningococcal meningitis is endemic; 22 of the 24 proband cases presented with recurrent meningococcal meningitis. " 08/01/1983 - "Meningococcal meningitis and complement (C6) deficiency." 10/17/1981 - "[Recurrent meningococcal meningitis associated with complement C6 deficiency (author's transl)]." 10/01/1979 - "A 51/2-year-old black girl with recurrent meningococcal meningitis and absence of the sixth component of complement (C6) is reported. " 05/22/2020 - "Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report."
2.	Complement Component 6 Deficiency 08/01/2022 - "Complement component 6 (C6) deficiency is a very rare genetic defect that leads to significantly diminished synthesis, secretion, or function of C6. " 01/01/2004 - "Molecular basis for complement component 6 (C6) deficiency in rats and mice." 12/01/1971 - "Evidence for the involvement of the sixth component of complement (C6) in normal blood coagulation is provided by the description of a coagulation abnormality in rabbits with a genetic C6 deficiency and by its correction with highly purified preparations of C6. " 05/22/2020 - "Recurrent meningococcal meningitis with complement 6 (C6) deficiency: A case report." 02/01/1974 - "Prompted by previous observations of defective blood clotting in rabbits deficient in the sixth component of complement (C6), an evaluation was made of the hemostatic functions of the homozygous proband of a newly recognized human kindred with hereditary C6 deficiency. "
3.	Atherosclerosis 11/01/1998 - "Complement C6 deficiency protects against diet-induced atherosclerosis in rabbits." 01/01/2004 - "Complement C6 deficiency has a protective effect on diet-induced atherosclerosis, indicating that C5b-9 assembly is required for the progression of atherosclerotic lesions. "
4.	Schizophrenia (Dementia Praecox) 01/01/1985 - "C3 and C6 complement types in schizophrenia." 01/01/1992 - "Polymorphic variants of C3, BF and C6 complement factors have been investigated in schizophrenic patients subdivided according to the existence or not of a family history of both schizophrenia and other psychiatric disorders. "
5.	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 04/15/1989 - "Inhibition of acute passive transfer experimental autoimmune myasthenia gravis with Fab antibody to complement C6."

Related Drugs and Biologics

1.	Complement System Proteins (Complement)
2.	Caspase 3 (Caspase-3)
3.	Anaphylatoxin C5a Receptor
4.	Complement Membrane Attack Complex (Membrane Attack Complex)
5.	Interleukin-6 (Interleukin 6)
6.	Bovine Serum Albumin
7.	RNA (Ribonucleic Acid)
8.	Proteins (Proteins, Gene)
9.	Complement Factor B (Factor B)
10.	Polysaccharides (Glycans)

Related Therapies and Procedures

1.	Intraperitoneal Injections