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Complement C5 (Complement 5)

C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Also Known As:
Complement 5; Complement Component 5; C5 Complement; Complement C5, Precursor; Precursor C5; Pro-C5; Pro-complement 5; C5, Complement; C5, Precursor; C5, Precursor Complement; Complement, C5; Component 5, Complement; Precursor Complement C5; Pro C5; Pro complement 5
Networked: 270 relevant articles (19 outcomes, 35 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Todaro, Thomas G: 7 articles (07/2011 - 09/2003)
2. Mollnes, Tom Eirik: 6 articles (01/2021 - 07/2011)
3. Shernan, Stanton K: 5 articles (07/2011 - 03/2004)
4. Nunn, Miles A: 4 articles (01/2022 - 01/2013)
5. Adams, Peter X: 4 articles (07/2011 - 08/2006)
6. Chen, John C: 4 articles (07/2011 - 03/2004)
7. Levy, Jerrold H: 4 articles (07/2011 - 08/2006)
8. Verrier, Edward D: 4 articles (07/2011 - 06/2005)
9. Rus, Horea: 4 articles (08/2009 - 09/2003)
10. Granger, Christopher B: 4 articles (08/2006 - 09/2003)

Related Diseases

1. Atypical Hemolytic Uremic Syndrome
2. Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria)
3. Inflammation (Inflammations)
4. COVID-19
5. Hemolysis

Related Drugs and Biologics

1. eculizumab
2. Monoclonal Antibodies
3. Complement System Proteins (Complement)
4. zilucoplan
5. ravulizumab
6. Antibodies
7. Interleukin-6 Receptors (Interleukin 6 Receptor)
8. Peptides (Polypeptides)
9. Immunoglobulin Fc Fragments
10. Biological Products

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1. Therapeutics
2. Cardiopulmonary Bypass (Heart-Lung Bypass)
3. Artificial Respiration (Mechanical Ventilation)
4. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
5. Percutaneous Coronary Intervention