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Complement C4 (Complement Component 4)

A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B.
Also Known As:
Complement Component 4; C4 Complement Component; Pro C4; C4 Complement; Complement 4; Complement C4, Precursor; Pro-C4; Pro-complement 4; C4, Complement; Complement Component, C4; Complement, C4; Component 4, Complement; Component, C4 Complement; Pro complement 4
Networked: 495 relevant articles (8 outcomes, 45 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Zhou, Bi: 6 articles (01/2016 - 01/2004)
2. Carroll, Michael C: 5 articles (01/2022 - 09/2002)
3. Yu, C Yung: 5 articles (01/2016 - 01/2004)
4. Chung, Erwin K: 4 articles (01/2016 - 01/2004)
5. Wu, Yee Ling: 4 articles (01/2016 - 06/2007)
6. Yang, Yan: 4 articles (01/2016 - 01/2004)
7. Lokki, Marja-Liisa: 4 articles (01/2014 - 12/2009)
8. Karsdal, Morten A: 3 articles (11/2022 - 01/2020)
9. Leeming, Diana Julie: 3 articles (02/2022 - 01/2019)
10. McCarroll, Steven A: 3 articles (01/2022 - 02/2016)

Related Diseases

1. Proteinuria
2. Body Weight (Weight, Body)
08/01/1994 - "Body weight, fat free mass, fat, plasma proteins, albumin, and C3 and C4 complement factors were stable. "
01/01/2019 - "In vivo studies revealed that diet supplementation with a mixture of essential oils and organic acids improved the final body weight and ADG of piglets (P < 0.05), increased the concentration of serum complement 4 (P < 0.05), and enhanced the fecal level of isovaleric acid (P < 0.05) compared with controls on day 28. "
01/01/2023 - "Similarly, dual GLP-1/GCG receptor agonist OXM-101 with increased relative GCG receptor agonism ameliorated NASH by eliciting dramatic body weight reductions to OXM-104, reflected in the improvement of liver and lipid enzymes and reduced PRO-C4 levels. "
01/01/2023 - "Thirty-eight days of treatment with a dual GLP-1/GCG receptor agonist, OXM-104, with increased GLP-1 receptor agonism in obese NASH mice was found to ameliorate the development of NASH by lowering body weight, improving liver and lipid profiles, reducing the levels of the fibrosis marker PRO-C4, and improving glucose control. "
02/01/2021 - "The grass carps fed with diets containing an appropriate dose of AOs for 60 days exhibited higher survival rates; body weight gains; specific growth rates; resistance to Aeromonas hydrophila; superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activities; and serum total protein, lysozyme, alkaline phosphatase, complement C3, complement C4 and interleukin-10 expression levels and lower feed conversion ratios and malondialdehyde, alanine aminotransferase, aspartate aminotransferase, IL-1β expression, IL-8 expression and tumor necrosis factor-α expression levels than the control group (p < 0.05). "
3. Systemic Lupus Erythematosus (Libman-Sacks Disease)
4. Hereditary Angioedemas
5. Hypertension (High Blood Pressure)
08/01/2000 - "Renal function improved, hypertension was controlled and serum levels of C3 and C4 complement components returned to normal within three months. "
12/01/2017 - "Multinomial logistic regression analysis showed that many factors might be associated with adverse pregnancy outcomes, including lupus nephritis, positive Ro/SSA antibody, positive La/SSB antibody, complement 3 and complement 4, positive aCL antibody, lupus recurrence, hypertension, and Raynaud's phenomenon. "
12/01/2017 - "Pregnancy outcomes before and after pregnancy were compared, and the associations with lupus nephritis, positive anti-Ro/SSA antibody, positive La/SSB antibody, complement 3 and complement 4, high blood pressure, positive anti- cardiolipin (aCL) antibody, Raynaud's phenomenon, and lupus recurrence were evaluated. "
01/01/2021 - "Patients with high blood pressure, low complement C4, low haematocrit, and high urine protein-to-creatinine ratio are more likely to have a declining eGFR trajectory, while the use of prednisone stabilizes the declining eGFR trajectory."
01/01/1977 - "Nevertheless, there remains a relatively large isiopathic group which, though possibly heterogeneous, displays a number of characteristic clinical and pathologic features including the following: 1. Steroid-resistant nephrotic syndrome; 2. Hematuria and hypertension; 3. Normal serum complement; 4. Progressive renal insufficiency; 5. Typical pathologic lesion most common in or restricted to juxtamedullary cortex; 6. Absence of clearly defined evidence of immune complex deposition by immunofluorescent or electron microscopic studies; 7. Recurrence of the lesion following renal transplantation. "

Related Drugs and Biologics

1. Complement C3 (C3 Complement)
2. Proteins (Proteins, Gene)
3. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4. Biomarkers (Surrogate Marker)
5. Creatinine
6. Interleukins
7. Acids
8. Rituximab (Mabthera)
9. Volatile Oils (Essential Oils)
10. isovaleric acid

Related Therapies and Procedures

1. Kidney Transplantation
2. Aftercare (After-Treatment)
3. Therapeutics
4. Renal Replacement Therapy (Therapies, Renal Replacement)
5. Enterosorption