Colonic Pseudo-Obstruction (Ogilvie Syndrome)

Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.

Also Known As:

Networked: 257 relevant articles (21 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Colonic Pseudo-Obstruction (Ogilvie Syndrome)
2.	Toxic Megacolon
3.	Carcinoma (Carcinomatosis)
4.	Neurogenic Bowel
5.	Ileus

Experts

1.	Bharucha, A E: 2 articles (12/2015 - 11/2001)
2.	Zinsmeister, A R: 2 articles (12/2015 - 11/2001)
3.	Lee, Jae-Wook: 2 articles (03/2010 - 06/2007)
4.	Chung, Nak-Gyun: 2 articles (03/2010 - 06/2007)
5.	Cho, Bin: 2 articles (03/2010 - 06/2007)
6.	Kim, Hack-Ki: 2 articles (03/2010 - 06/2007)
7.	Cappell, Mitchell S: 2 articles (05/2008 - 06/2004)
8.	Li, Zhao-Zhu: 2 articles (01/2008 - 04/2007)
9.	Baron, Todd H: 2 articles (05/2003 - 12/2002)
10.	Camilleri, M: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Colonic Pseudo-Obstruction:

1.	Neostigmine (Neostigmine Bromide)IBA 12/01/2012 - "Colonoscopy is superior to neostigmine for Ogilvie's syndrome and should be considered first-line therapy, although neostigmine is useful in select patients and repeat interventions." 12/01/2012 - "Colonoscopy is superior to neostigmine in the treatment of Ogilvie's syndrome." 03/24/2001 - "Neostigmine was recently shown to be effective and safe for the treatment of Ogilvie's syndrome. " 05/01/2000 - "We have shown that neostigmine is a safe and effective treatment for acute colonic pseudo-obstruction." 05/01/2000 - "Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction."
2.	Cholinesterase Inhibitors (Anticholinesterases)IBA 02/01/2004 - "The evidence that cholinesterase inhibitors are effective in relieving acute colonic pseudo-obstruction raised interest in the pharmacological management of this condition. " 11/01/2001 - "Recent reports of the efficacy of cholinesterase inhibitors in relieving acute colonic pseudo-obstruction have fuelled interest in the pharmacological treatment of this condition. " 12/01/2015 - "Acetylcholinesterase inhibitors (ACIs), e.g., neostigmine, are known to increase upper and lower gastrointestinal (GI) motility and are used to treat acute colonic pseudoobstruction. " 11/01/2013 - "Cholinesterase inhibitors such as neostigmine are used for acute colonic pseudo-obstruction, but cardio-bronchial side-effects limit use. "
3.	Anti-Bacterial Agents (Antibiotics)IBA 05/01/1977 - "A double-blind crossover study using placebo and antibiotics effective against either aerobic or anaerobic organisms has been performed to elucidate the role of intestinal microflora in the pathogenesis of colonic pseudo-obstruction, which is now established as an important complication of jejunoileal bypass. "
4.	prucaloprideIBA 11/01/2013 - "Potential synergy between prucalopride and donepezil activity calls for exploration of this combination as a safer, more effective treatment of colonic pseudo-obstruction."
5.	donepezil (Aricept)FDA LinkGeneric 11/01/2013 - "Potential synergy between prucalopride and donepezil activity calls for exploration of this combination as a safer, more effective treatment of colonic pseudo-obstruction."
6.	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 05/01/2006 - "Effect of polyethylene glycol electrolyte balanced solution on patients with acute colonic pseudo obstruction after resolution of colonic dilation: a prospective, randomised, placebo controlled trial." 12/01/2007 - "Intestinal pseudoobstruction or Ogilvie's syndrome occurred in 4.1% of patients in the placebo group, 5.5% of patients in the lactulose group, and 1.0% of patients in the polyethylene glycol group. " 03/13/2007 - "Ten patients with megacolon confirmed by barium enema examination, 4 males and 6 females, aged 38 (15 - 66), with a mean course of 10 years (2 weeks - 23 years), all complicated by severe constipation and 5 cases with colonic obstruction confirmed by X-ray examination, 1 being diagnosed as with Hirschsprung' disease, 3 secondary to chronic constipation, 1 with diabetes mellitus, 1 with a history of anorectal malformation, 4 with colonic pseudo-obstruction, and 4 with colonic pseudo-obstruction, were treated with combined conservative therapy including tegaserod (6 mg 2/d), polyethylene glycol (PEG) 4000 (20 - 40 g/d), and liuweianxiao (traditional Chinese medicine, 5 # 3/d). "
7.	Cisapride (Propulsid)FDA Link 02/26/1994 - "[A convulsive crisis in a patient with Ogilvie's syndrome treated with cisapride]." 01/01/1994 - "Few cases of Ogilvie's syndrome successfully treated with cisapride have been reported in the literature. " 10/01/1990 - "Cisapride in Ogilvie's syndrome." 03/01/1990 - "To the authors' knowledge, this is the first reported case of successful treatment of acute colonic pseudoobstruction with cisapride." 05/01/1997 - "This case report describes a patient with Ogilvie's syndrome; he has been treated with cisapride and colonoscopic decompression."
8.	Erythromycin (Erycette)FDA LinkGeneric 01/01/2008 - "Intravenous low-dose erythromycin could be an efficacious treatment for acute colonic pseudo-obstrcution (ACPO)/ Ogilvie's syndrome in children." 04/07/2007 - "Treatment of pediatric Ogilvie's syndrome with low-dose erythromycin: a case report." 09/01/1995 - "[Erythromycin: an alternative in conservative management of Ogilvie syndrome]." 02/09/1991 - "Erythromycin for reflex ileus in Ogilvie's syndrome." 07/01/1997 - "Acute colonic pseudo-obstruction (Ogilvie's syndrome) treated with erythromycin."
9.	Narcotics (Narcotic Analgesics)IBA 03/01/2006 - "Acute colonic pseudo-obstruction after colonoscopy in a young woman on narcotics." 01/01/1998 - "36 cases (63.2%) got i.v. narcotics prior to development of Ogilvie's syndrome. " 02/01/1985 - "Colonic pseudo-obstruction (Ogilvie's syndrome) may occur in surgical patients, particularly those who have had orthopedic or blunt trauma, have uremia or diabetes, have complex metabolic or cardiac failure, have metastatic cancer involving the lymph nodes and neural tissue, or are addicted to narcotics. " 06/01/2004 - "Narcotics, phenothiazines, vincristine, atropine, nifedipine, and tricyclic antidepressants are associated with colonic pseudo-obstruction. " 12/01/1992 - "Patients with Ogilvie's syndrome were being treated with narcotics (56 percent), H-2 blockers (52 percent), phenothiazines (42 percent), calcium-channel blockers (27 percent), steroids (23 percent), tricyclic antidepressants (15 percent), and epidural analgesics (6 percent) at diagnosis. "
10.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 08/01/1987 - "Gastrointestinal effects of tricyclic antidepressants: Ogilvie's syndrome." 06/01/2004 - "Narcotics, phenothiazines, vincristine, atropine, nifedipine, and tricyclic antidepressants are associated with colonic pseudo-obstruction. " 12/01/1992 - "Patients with Ogilvie's syndrome were being treated with narcotics (56 percent), H-2 blockers (52 percent), phenothiazines (42 percent), calcium-channel blockers (27 percent), steroids (23 percent), tricyclic antidepressants (15 percent), and epidural analgesics (6 percent) at diagnosis. " 10/01/1993 - "Medications associated with colonic pseudoobstruction include narcotics, phenothiazines, vincristine, atropine or other anticholinergics, ganglionic blocking agents, and tricyclic antidepressants. "

Therapies and Procedures

1.	Decompression 04/15/1990 - "The prognosis of an acute colonic pseudoobstruction has improved significantly since the introduction of colonoscopic decompression. " 01/01/1998 - "In conclusion, we believe that endoscopic decompression and tube placement is effective and safe for acute colonic pseudo-obstruction not responding to 24 hour conservative treatment." 08/01/1996 - "Colonoscopic decompression is effective and safe for acute colonic pseudo-obstruction that does not respond to conservative therapy. " 12/01/1992 - "Colonoscopic decompression in Ogilvie's syndrome is safe and effective management. " 01/01/1988 - "The study compares the efficacy of colonoscopic decompression versus decompression and tube placement in the treatment of Ogilvie's syndrome. "
2.	Cecostomy 08/01/2006 - "Percutaneous cecostomy is used to treat recurrent colonic pseudoobstruction or obstipation in children and adults with multiple medical comorbidities. " 11/01/2004 - "Although acute colonic pseudo-obstruction is uncommon, it is important that obstetric practitioners recognize this clinical entity as the potentially fatal consequences of cecal perforation can be prevented by tube cecostomy." 11/01/2004 - "We report the occurrence of acute colonic pseudo-obstruction post-cesarean delivery in which prompt recognition of impending cecal perforation allowed appropriate management by tube cecostomy. " 05/01/2003 - "In 1 of the 2 patients with acute colonic pseudo-obstruction, the percutaneous endoscopic cecostomy tube was clamped and subsequently removed 10 weeks after placement; in the other patient with acute colonic pseudo-obstruction, the percutaneous endoscopic cecostomy tube remains in place. " 10/01/1995 - "Management of cecal perforation secondary to Ogilvie's syndrome by laparoscopic tube cecostomy."
3.	Drug Therapy (Chemotherapy) 06/01/2007 - "Recently, the efficacy of pharmacologic treatment has been reported in adults, but no such data have yet been reported in children for treatment of acute colonic pseudo-obstruction resulting from chemotherapy. " 04/01/2012 - "Although acute colonic pseudo-obstruction (ACPO) complicating chemotherapy is still a controversial entity, it is one with which radiologists should be familiar. " 04/01/2012 - "Acute colonic pseudo-obstruction complicating chemotherapy in paediatric oncohaematological patients: clinical and imaging features." 08/01/1987 - "The case of a 73-year-old man who developed acute colonic pseudo-obstruction (Ogilvie's syndrome) following chemotherapy for lymphoma is reported. " 07/20/2012 - "Ogilvie's syndrome during chemotherapy with high-dose methotrexate for primary CNS lymphoma."
4.	Colectomy 01/01/1988 - "We present a case of advanced scleroderma bowel complicated by colonic pseudo-obstruction, which was dramatically improved by subtotal colectomy. " 03/01/2014 - "Hand-assisted laparoscopic subtotal colectomy with cecorectal anastomosis for chronic idiopathic colonic pseudo-obstruction: report of a case." 03/24/1990 - "[Recurrent pre- and post-pregnancy colonic pseudo-obstruction treated by total colectomy]." 10/01/1987 - "Five of seven patients with primary colonic pseudoobstruction achieved symptomatic relief only after subtotal colectomy and ileoproctostomy." 01/01/1990 - "A second one developed a chronic colonic pseudo-obstruction with megacolon treated by subtotal colectomy. "
5.	Enema (Enemas) 03/01/1999 - "We believe the safety, efficacy, and ease of this procedure make Cystografin enema optimal first-line treatment for acute colonic pseudo-obstruction." 03/01/1999 - "We performed a retrospective study to assess the efficacy of Cystografin enema for colonic decompression in Ogilvie's syndrome. " 04/01/1995 - "A prospective study was undertaken in 12 consecutive patients (median age, 60 (range, 38-98) years) with contrast enema-proven Ogilvie's syndrome (median duration, four (range, two-nine) days) Satisfactory clinical decompression of large bowel distention was attained in 11 patients, although one required colectomy for subsequent recurrence and ischemia. " 11/01/1995 - "In the appropriate clinical setting this approach could exclude the presence of obstruction and avoid unnecessary barium enemas in the majority of patients with colonic pseudo-obstruction." 03/01/1990 - "A 73-yr-old white woman admitted with lobar pneumonia and congestive heart failure developed progressive colonic pseudoobstruction (Ogilvie's syndrome) 2 days after admission which was unrelieved by diatrizoate meglumine (Gastrografin, Squibb Canada, Montreal) enema and rectal tube. "