Coloboma

12/01/2013 - "The aim of this study was to report the observations on the pattern of retinal BVs in eyes with fundus coloboma. "
11/01/1968 - "[Clinical and electroretinographic study of a case of coloboma of the optic nerve with absence of retinal vascularization]."
09/01/2015 - "[Bilateral chorio-retinal coloboma]."
01/01/2015 - "Homozygous zebrafish embryos from both lines developed variable lens and coloboma phenotypes: mab21l2Q48Sfs*5 embryos demonstrated severe lens and retinal defects with complete lethality while mab21l2R51_F52del mutants displayed a milder lens phenotype and severe coloboma with a small number of fish surviving to adulthood. "
05/15/2014 - "Analysis of Sall2-deficient mouse embryos revealed delayed apposition of the optic fissure margins and the persistence of an anterior retinal coloboma phenotype after birth. "

05/01/2009 - "Fifty-one cases of congenital eyelid colobomas including the functional and cosmetic rehabilitation of patients who were treated over a period of 18 years with an average follow-up of 4.7 years were retrospectively reviewed. "
01/01/2005 - "Congenital iris coloboma repair using the same incision is difficult but provides good cosmetic and functional results."
05/01/2002 - "Congenital upper eyelid colobomas are a potential threat to vision at an early age and a significant cosmetic blemish later in life. "
11/01/2006 - "In patients with congenital iris coloboma, phacoemulsification with in-the-bag IOL implantation followed by this pupilloplasty technique was effective in providing functional and cosmetic repair of a congenital iris coloboma."
05/01/2003 - "The modified McCannel suture technique provides acceptable functional and cosmetic repair of congenital iris colobomas."

01/01/2000 - "Despite the ubiquitous role of SNAP-25 in synaptic transmission, and uniformly decreased expression in the mutants, coloboma mice show marked deficits in Ca2+-dependent dopamine release selectively in dorsal but not ventral striatum. "
11/20/1999 - "Transgenic rescue of SNAP-25 restores dopamine-modulated synaptic transmission in the coloboma mutant."
01/01/2010 - "Targeted deletion of the D2, but not the D3 or the D4, dopamine receptor in coloboma mice eliminated the hyperactivity; depleting D2 dopamine receptors also restored the excess dopamine overflow that may drive the hyperactivity to normal concentrations. "
04/01/2007 - "Amphetamine treatment reduced locomotor activity in coloboma mice, but induced a robust increase in dopamine overflow suggesting that abnormal regulation of dopamine efflux does not account for the behavioral effect. "
11/30/2001 - "Previous research has determined that there is an increase in the concentration of norepinephrine but a decrease in dopamine utilization in the striatum and nucleus accumbens of coloboma mice. "

01/01/2010 - "Targeted deletion of the D2, but not the D3 or the D4, dopamine receptor in coloboma mice eliminated the hyperactivity; depleting D2 dopamine receptors also restored the excess dopamine overflow that may drive the hyperactivity to normal concentrations. "
01/01/2010 - "Here we use the hyperactive mouse mutant coloboma to identify D2-like dopamine receptor subtypes that mediate the hyperactivity and response to amphetamine; we have previously demonstrated that D1-like dopamine receptors are not involved. "
04/01/2007 - "However, the D2-like dopamine receptor antagonists haloperidol and raclopride, but not the D1-like dopamine receptor antagonist SCH23390, blocked the amphetamine-induced reduction in locomotor activity in coloboma mice, providing direct evidence that D2-like dopamine receptors mediate the effect of amphetamine in these mice. "

05/01/1996 - "When perfluorocarbon liquids are used during pars plana vitrectomy, the possibility of silicone-induced pupillary block in the presence of an inferior iris coloboma should not be overlooked."
07/01/2010 - "In 1 patient (16%), subclinical retinal detachment that did not increase during the follow-up after silicone oil removal was detected just beyond the margin of the coloboma. "
07/01/2010 - "The purpose was to study the anatomical outcome of choroidal coloboma with retinal detachment managed by pars plana vitrectomy with silicone oil tamponade using optical coherence tomography. "
06/01/2006 - "To study the long term anatomical and visual outcome of choroidal coloboma with retinal detachment managed by pars plana vitrectomy with silicone oil tamponade. "
11/01/2014 - "This is a case series of five patients with CHC and RD who were successfully operated using one of two different surgical techniques: pars plana vitrectomy (PPV)+silicone oil internal tamponade and/or scleral buckle with encircling band with laser photocoagulation (SB+EB+LPC) around the coloboma. "

05/01/2013 - "The purpose of this study was to describe the physiologic and morphometric changes in iridal tissue involved in ocular coloboma in FLS mice. "
11/01/2013 - "Complete iridal coloboma was present in 37% of eyes. "
05/01/2013 - "However, the same pathogenesis should result in iridal coloboma that has not been reported in this strain. "
08/01/2011 - "The objective of the current study was to evaluate whether inferior ectopic pupil is associated with iridal coloboma and other types of ocular coloboma in RCS rats. "
05/01/2013 - "Iridal coloboma induces dyscoria during miosis in FLS mice."

10/01/1977 - "A fluorescein angiographic study of a case with coloboma."
02/01/2011 - "Funduscopy and fluorescein angiography (FA) showed CNV in the superior extrafoveal region with chorioretinal coloboma reaching just inferior to the optic disc. "
05/01/2007 - "However clinically as well as on fluorescein angiography, no optic pit or coloboma could be identified. "
09/01/2005 - "The microvascular changes of the coloboma were studied using the techniques of fluorescein angiography, histology and scanning electron microscopy (SEM) of vascular corrosion casts. "
03/01/2010 - "Although fluorescein angiography was not performed and the presence of a peripapillary subretinal neovascular membrane could not be ruled out, an atypical coloboma, optic nerve head pit, or peripapillary subretinal neovascular membrane was not observed during biomicroscopy or scanning laser ophthalmoscopy. "

03/01/2003 - "A previous study found an association between ADHD and two polymorphisms in the 3' untranslated region (UTR) of SNAP-25, a gene encoding a synaptic vesicle docking protein known to play a role in the hyperactivity observed in the Coloboma mouse strain. "

01/01/2004 - "To review the association of autism spectrum disorder (ASD) in individuals manifesting thalidomide embryopathy and Möbius sequence and compare them with three new studies in which ASD was also associated with ocular and systemic malformations: (1) a Swedish study of individuals with CHARGE association (Coloboma, Heart, choanal Atresia, developmental or growth Retardation, Genital anomaly, and Ear involvement); (2) a Swedish study of Goldenhar syndrome; and (3) Brazilian Möbius syndrome (sequence) study. "

10/01/2006 - "Ocular defects including microphthalmia and uveal coloboma, which have previously been shown to result from ethanol administered by gavage or via intraperitoneal injection on these days, served as the developmental end point for this study. "

04/01/2014 - "To evaluate the visual and refractive outcomes after phacoemulsification surgery in eyes with isolated lens coloboma. "
10/01/2013 - "Outcomes of phacoemulsification in eyes with congenital choroidal coloboma."
05/01/2006 - "A modification is presented of the standard application of iris hooks to retract the superior iris and support the inferior capsule during phacoemulsification in cases of iris coloboma with inferior zonular deficiency. "
04/01/2014 - "Phacoemulsification with CTR and intraocular lens implantation is an effective and safe option for providing a refractive correction and a significant visual improvement in eyes with isolated lens coloboma."
09/01/2012 - "We describe a case of a 39-year-old male with an atypical coloboma that was managed successfully with phacoemulsification, capsular tension ring and intraocular lens implantation. "

11/01/2014 - "Our study confirmed that it is safe to perform a sclerotic puncture 4 mm posterior to the limbus for vitrectomy in patients with choroidal colobomas with or without microcornea."
02/01/2012 - "The patient was treated by injection of 0.05 mL of autologous platelet concentrate into the coloboma along with vitrectomy and gas exchange. "
06/01/2014 - "Pars plana vitrectomy was performed in five eyes with retinal detachment resulting from choroidal coloboma involving the disk. "
06/01/2014 - "Vitrectomy treatment of retinal detachments related to choroidal coloboma involving the disk."
07/01/2010 - "Optical coherence tomography after pars plana vitrectomy for retinal detachment related to choroidal coloboma."

04/01/2000 - "Spectacles were prescribed most frequently for myopia associated with choroidal coloboma. "
09/01/2006 - "Children with aphakia (17), coloboma (5), refractive error (5) and microphthalmos (4) benefited from spectacles. "
04/01/2000 - "The aim of the study was (1) to determine the need for spectacles in children in Southern India with coloboma, microphthalmos and microcornea, (2) to describe their refractive errors and (3) to assess their needs for low vision aids (LVAs). "

04/01/2014 - "Phacoemulsification with CTR and intraocular lens implantation is an effective and safe option for providing a refractive correction and a significant visual improvement in eyes with isolated lens coloboma."
09/01/2012 - "We describe a case of a 39-year-old male with an atypical coloboma that was managed successfully with phacoemulsification, capsular tension ring and intraocular lens implantation. "

06/01/2014 - "Carefully titrated diode laser burns were applied in the functional border of the disk (the border of papillomacular bundle) to reduce the nerve fiber layer damage, and endolaser of three to four rows was performed along the border of the coloboma. "
06/01/2014 - "To evaluate the anatomical and functional outcomes of retinal detachment with choroidal coloboma involving the disk, by incising the entire intercalary membrane along the margin of the coloboma and displacing part of the macular retina to healthy retinal pigment epithelium (RPE), and then treating the entire margin of the RPE surrounding the coloboma with diode laser. "
06/01/2014 - "For these retinal detachment eyes with choroidal coloboma involving the disk, complete vitrectomy, incising the entire intercalary membrane along the margin of the coloboma and displacing part of the macular retina to healthy RPE, treating the entire margin of the RPE surrounding the coloboma with diode laser provides an effective treatment for this complicated type of retinal detachment with good long-term anatomical outcome."