Collagen Diseases (Collagen Disease)

Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)

Also Known As:

Networked: 591 relevant articles (17 outcomes, 66 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Heart Diseases (Heart Disease)
2.	Hepatitis
3.	Interstitial Lung Diseases (Interstitial Lung Disease)
4.	Vasculitis (Vasculitides)
5.	Infection

Experts

1.	Jinnin, Masatoshi: 4 articles (09/2013 - 10/2005)
2.	Furukawa, Fukumi: 4 articles (06/2012 - 01/2002)
3.	Fukushima, Satoshi: 3 articles (09/2013 - 09/2011)
4.	Makino, Katsunari: 3 articles (09/2013 - 09/2011)
5.	Makino, Takamitsu: 3 articles (09/2013 - 09/2011)
6.	Ihn, Hironobu: 3 articles (09/2013 - 09/2011)
7.	Sakai, Keisuke: 3 articles (09/2013 - 09/2011)
8.	Kajihara, Ikko: 3 articles (09/2013 - 09/2011)
9.	Harigae, Hideo: 3 articles (01/2013 - 01/2009)
10.	Takasaki, Yoshinari: 3 articles (08/2009 - 10/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Collagen Diseases:

1.	sarpogrelateIBA 06/01/2012 - "Sarpogrelate hydrochloride (sarpogrelate) is a selective 5-HT(2A) antagonist and was supposed to be effective for Raynaud's phenomenon with collagen disease. " 06/01/1998 - "To evaluate clinical efficacy of sarpogrelate hydrochloride (SPG), a novel 5HT2- serotonergic receptor antagonist, for Raynaud's phenomenon associated with collagen diseases. " 06/01/1998 - "[Sarpogrelate hydrochloride for Raynaud's phenomenon of patients with collagen diseases]." 06/01/2012 - "Sarpogrelate has not been investigated regarding the effects, safety and quality of life (QOL) in patient with skin ulcers of collagen disease. " 10/01/2000 - "Twenty-seven patients with either collagen disease or diseases associated with Raynaud's phenomenon were given a combined 5-HT2 and serotonin receptor antagonist, sarpogrelate hydrochloride. "
2.	AutoantibodiesIBA 10/01/1999 - "In early studies concerning the nuclear structure, autoantibodies derived from patients with collagen disease had a significant role. " 08/01/1969 - "[Study of antinuclear autoantibodies by immunofluorescence technic in collagen diseases]." 05/01/2006 - "There were no autoantibodies related to collagen diseases in the serum. " 09/10/2004 - "[Collagen diseases and autoantibodies--current topics]." 08/22/1987 - "The relationship between these autoantibodies and collagen diseases is described in terms of their usefulness in diagnosis and follow-up. "
3.	Complement System Proteins (Complement)IBA 09/01/1988 - "[Clinical study of collagen diseases and complement abnormalities]." 10/10/2003 - "[Clinical significance of complement analysis in collagen diseases]." 12/10/1998 - "[Progress in clinical tests and the pathophysiological tests of collagen diseases--complement]." 11/01/1975 - "A knowledge of the complement system in patients with collagen diseases is of interest as it may serve to indicate the existence of activity or non-activity in these diseases. " 06/01/1953 - "Serum complement in children with collagen diseases."
4.	CollagenIBA 08/15/2006 - "The results help to explain why collagen fibers found in nature consist of TC molecules with lengths in the proximity of 300 nm and advance the understanding how collagen diseases that change intermolecular adhesion properties influence mechanical properties." 02/01/1992 - "We studied the clinico-pathological correlation of collagen disease-related pulmonary lesions to examine the pathological and radiological features of collagen lung, and the effect of steroid therapy. " 03/01/1987 - "An understanding of collagen maturation, and the pathophysiologic and biophysical consequences of abnormalities at this level of biochemical organization, permits more specific understanding of ocular dysmorphology and collagen diseases." 01/01/1979 - "These structures appear to occur rather widely in collagen metabolism disorders (tumours of neurogenic origin, some skin tumours, collagen diseases)." 01/01/1978 - "The obtained results suggested the inhibition of collagen maturation as one of biochemical defects of connective tissue in drug-induced collagen disease-like syndrome."
5.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2000 - "Several journals have reported that cyclosporin may be effective in the treatment of interstitial pneumonitis associated with collagen disease. " 12/01/1999 - "This study was performed to investigate the efficacy and safety of cyclosporin A (CsA) for the treatment of interstitial pneumonia (IP) associated with collagen diseases in Japan. " 12/01/1999 - "[Nation-wide survey for the treatment with cyclosporin A of interstitial pneumonia associated with collagen diseases]." 01/01/1987 - "The demonstration in patients with progressive systemic sclerosis of abnormal activation of immunity system cells suggested the use in this collagen disease of a new immunosuppressive agent, cyclosporine A, but clinical utility of this drug remains to be demonstrated. "
6.	Carbon MonoxideIBA 10/01/2004 - "Indications are collagen diseases with multiorgan involvement, where co-medications are frequently necessary. " 07/01/2001 - "Because of relatively low efficacy, considerable side effect and high cost, HCV infected patients complicated with the other disease(patients with hematologic dysorders, chronic renal failure on hemodialysis, HIV co-infection and collagen disease) have been excluded from large trials evaluating the efficacy of IFN or in combination with ribabirin. " 07/01/1993 - "We found that CO-N, a galactosaminoglycan from Cordyceps ophioglossoides, reacted with sera from patients with some collagen diseases. "
7.	Endothelin Receptors (Endothelin Receptor)IBA 11/01/2008 - "Current treatment algorithms for PAH recommend bosentan as first-line treatment for PAH in functional class III. Recent many trials suggested that endothelin receptor antagonist, bosentan, caused good results in idiopathic PAH and PAH associated with chronic thromboembolism, collagen diseases, and congenital heart diseases."
8.	bosentan (Tracleer)FDA Link 11/01/2008 - "Current treatment algorithms for PAH recommend bosentan as first-line treatment for PAH in functional class III. Recent many trials suggested that endothelin receptor antagonist, bosentan, caused good results in idiopathic PAH and PAH associated with chronic thromboembolism, collagen diseases, and congenital heart diseases."
9.	AntigensIBA 03/01/2011 - "Blood laboratory tests showed positive anti-nuclear antigen (x 80), but collagen diseases were not identified. " 09/01/1998 - "As corresponding antigens for ANAs vary considerably, patients with collagen diseases usually demonstrate several ANAs coincidentally, making difficult to detect the full spectrum of ANAs in each patient's serum. " 04/01/1997 - "The involvement of antigen-specific T cells in the pathogenesis of collagen diseases is still controversial. " 04/01/1997 - "Significance of antigen-specific T cell clones in collagen diseases: analyses with a novel T cell clonality evaluation system." 09/01/1996 - "In the patient with collagen disease, CMV-antigen was positive in their lymphocytes and monocytes. "
10.	ThrombomodulinIBA 01/01/1994 - "These results may indicate that plasma thrombomodulin measurement may be helpful for evaluating vascular injury in patients with collagen diseases." 10/01/1994 - "We found that serum levels of thrombomodulin were high in about 35% of patients with sarcoidosis, interstitial pneumonia associated with collagen diseases, or idiopathic interstitial pneumonia. " 09/01/2000 - "Serum soluble thrombomodulin is known to be a factor in visceral vascular disorders such as organic vasculitis in collagen diseases, but recently it has also been reported as a predictor of thrombotic crisis in thrombotic diseases. " 09/01/1992 - "A relatively high mean thrombomodulin level was observed in DIC, liver disease, and collagen disease. " 09/01/1992 - "Abnormally high thrombomodulin values (greater than normal mean value + 3 SD) were found in 32.3% of patients with hematological malignancies, 57.7% of patients with liver disease, 39.3% of patients with diabetes mellitus, 30.0% of patients with collagen disease, 23.1% of patients with thrombotic disease, and 69.0% of patients with DIC. "

Therapies and Procedures

1.	Renal Dialysis (Hemodialysis) 01/01/1989 - "It was also observed that the Bb levels in patients undergoing hemodialysis were significantly higher than those in various renal and collagen diseases. " 07/01/2009 - "The study excluded patients with hemodialysis requirement, heart failure, malignant neoplasm, or collagen disease. " 02/01/2001 - "Taking up diabetes mellitus, hemodialysis, collagen disease and lung cancer as the representatives of compromised hosts, we studied the propriety of chemoprophylaxis to prevent the development of tuberculosis and the standard for the subjects in the case of chemoprophylaxis being given. " 01/01/2009 - "The evaluated influential factors on the outcome at one month included age, sex, presence of arteriosclerosis obliterans, collagen disease, hypertension, diabetes mellitus, hemodialysis, wound infection, wound management, and SPP ≥ 40 mmHg. " 10/01/1988 - "A higher prevalence of anti-pHSA antibodies was found in hepatitis B virus (HBV)-related CAH and hemodialysis patients compared with NANB-related CAH, collagen diseases and lymphomas. "
2.	Vegetarian Diet (Vegetarianism) 01/01/1990 - "In most cases health resort managers had withdrawn effective medication or instituted vegetarian diets for patients with severe catabolic conditions, such as collagen diseases, renal insufficiency or inflammatory bowel disease. "
3.	Pericardiectomy 06/01/1978 - "Seven patients with constrictive pericarditis associated with collagen disease underwent pericardiectomy with good results in all but one. "
4.	Liver Transplantation 12/15/2009 - "After excluding patients with malignancy, collagen disease, bone marrow failure, prematurity, hereditary disease, congenital neutropenia, immunodeficiency, or status post-liver transplantation, 735 admissions with acquired neutropenia were included in our study. "
5.	General Anesthesia 01/01/1997 - "Although only a small number of patients were included in this study, these results suggested that 1) elective abdominal surgery can be as safely performed under epidural anesthesia alone as with general anesthesia even for patients with collagen diseases, and 2) the patients with collagen diseases, who preoperatively showed a dysfunction of the vital organs, might be at a higher risk for abdominal surgery."