Coformycin

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ferella, Marcela: 1 article (11/2005)
2.	Goto, Hiro: 1 article (11/2005)
3.	Kristensson, Krister: 1 article (11/2005)
4.	Masocha, Willias: 1 article (11/2005)
5.	McCaffrey, Ronald: 1 article (11/2005)
6.	Petitto-Assis, Fabricio: 1 article (11/2005)
7.	Rottenberg, Martin E: 1 article (11/2005)
8.	Wigzell, Hans: 1 article (11/2005)
9.	Bajza, Agnes: 1 article (04/2003)
10.	Cseppentõ, Agnes: 1 article (04/2003)

Related Diseases

1.	Ischemia 10/01/1993 - "EHNA and coformycin preserved cardiac ATP levels and increased endogenous tissue adenosine during ischemia. " 05/01/1991 - "Ten-day-old cultured cells were made ischemic for 6 hr, and allowed to recover for 24 hr. At the end of ischemia, cells were incubated with ADO, theophylline (T), dipyridamole (D), coformycin (C) or combined agents for 3 hr. Total AN (TAN) were determined after 3 and 24 hr of recovery. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 10/01/1993 - "Furthermore, EHNA and coformycin reduced the extent of myocardial ischemia-reperfusion injury, as indicated by the approximately 55% reduction in creatine phosphokinase release. "
3.	Reperfusion Injury 10/01/1993 - "Furthermore, EHNA and coformycin reduced the extent of myocardial ischemia-reperfusion injury, as indicated by the approximately 55% reduction in creatine phosphokinase release. "
4.	Neoplasms (Cancer) 07/01/1997 - "Inclusion of the adenosine deaminase inhibitor coformycin (10 microM) and the adenosine kinase inhibitor 5'-iodotubercidin (0.1 microM) in the microdialysis perfusion buffer increased extracellular adenosine concentration in tumors to as high as 13 microM. "
5.	Infections 11/01/2005 - "We show here that intraperitoneal injection of the adenosine analogue cordycepin (3'-deoxyadenosine), together with an adenosine deaminase (ADA) inhibitor (coformycin or deoxycoformycin), cures Trypanosoma brucei brucei infection in mice. "

Related Drugs and Biologics

1.	Adenosine (Adenocard)
2.	Adenosine Deaminase
3.	Dipyridamole (Persantine)
4.	9-(2-hydroxy-3-nonyl)adenine (EHNA)
5.	Pentostatin (Nipent)
6.	Thyroxine (Levothyroxine)
7.	Theophylline (Theon)
8.	Oxygen (Dioxygen)
9.	Enzymes
10.	Creatine Kinase (Creatine Phosphokinase)

Related Therapies and Procedures

1.	Intraperitoneal Injections