Cobra Neurotoxin Proteins

Toxins, contained in cobra (Naja) venom that block cholinergic receptors; two specific proteins have been described, the small (short, Type I) and the large (long, Type II) which also exist in other Elapid venoms.

Also Known As:

Networked: 13 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Qin, Zheng-Hong: 6 articles (12/2020 - 03/2006)
2.	Reid, Paul F: 4 articles (12/2020 - 03/2006)
3.	Han, Rong: 4 articles (11/2014 - 03/2006)
4.	Lin, Fang: 3 articles (12/2020 - 12/2016)
5.	Shen, Jian: 2 articles (11/2014 - 07/2013)
6.	Chen, Bo-Wen: 2 articles (04/2006 - 03/2006)
7.	Gu, Zhen-Lun: 2 articles (04/2006 - 03/2006)
8.	Raymond, Laurence N: 2 articles (04/2006 - 03/2006)
9.	Zhang, Hui-Ling: 2 articles (04/2006 - 03/2006)
10.	Huang, Jun: 1 article (12/2016)

Related Diseases

1.	COVID-19 12/01/2020 - "Author Correction: Cobrotoxin could be an effective therapeutic for COVID-19." 01/01/2020 - "Cobrotoxin could be an effective therapeutic for COVID-19."
2.	Neoplasms (Cancer) 07/01/2013 - "The aim of this study is to assay the anti-tumor effect of cobrotoxin in cell line A549, and also to explore its possible mechanism related to autophagy and P38-MARK pathway. " 07/01/2013 - "And the activating of P38-MARK pathway, then upregulating autophagy, was involved in cobrotoxin induced anti-tumor process. " 01/01/2011 - "Paradoxically α-cobrotoxin from Naja atra showed the tendency to enhance tumor growth although, even in this case, the statistical significance was not reached.In" 11/01/2014 - "Cobrotoxin exhibited inhibitory activity on the human lung cancer A549 cells transplanted into the nude mice, suppressing the tumor growth rate by 43.4% (cobrotoxin 40 μg/kg group). " 07/01/2013 - "It has been proven that cobrotoxin has anti-tumor effect while its role in lung cancer is rarely studied. "
3.	Cancer Pain 11/01/2006 - "Cobrotoxin produces intense analgesia but it has an onset of response of 1-3 h which hampers its clinical use in cancer pain. " 11/01/2006 - "Cobrotoxin-containing analgesic compound to treat chronic moderate to severe cancer pain: results from a randomized, double-blind, cross-over study and from an open-label study."
4.	Lung Neoplasms (Lung Cancer) 11/01/2014 - "Cobrotoxin inhibits the growth of human lung cancer A549 cells in vitro and A549 cells transplanted into nude mice. " 11/01/2014 - "Cobrotoxin exhibited inhibitory activity on the human lung cancer A549 cells transplanted into the nude mice, suppressing the tumor growth rate by 43.4% (cobrotoxin 40 μg/kg group). " 07/01/2013 - "It has been proven that cobrotoxin has anti-tumor effect while its role in lung cancer is rarely studied. " 01/01/2011 - " determined the activity of α-neurotoxins from Naja atra (short-chain neurotoxin, α-cobrotoxin) and Naja kaouthia (long-chain neurotoxin, α-cobratoxin) in vitro by cytotoxicity measurements in 5 lung cancer cell lines, by colony formation assay with α7nAChRs expressing and non-expressing cell lines and in vivo by assessing tumor growth in an orthotopic Non-Obese Diabetic/Severe Combined Immunodeficient (NOD/SCID) mouse model system utilizing different treatment schedules and dosages.No"
5.	Pain (Aches) 04/01/2006 - "In light of the antinociceptive activity of the short-chain neurotoxin, cobrotoxin, and other acetylcholine antagonists, the antinociceptive activity and mechanisms of cobratoxin (CTX), a long-chain postsynaptic alpha-neurotoxin, was investigated in rodent pain models. " 03/01/2006 - "Objective To investigate the analgesia induced by cobrotoxin (CT) from venom of Naja naja atra, and the effects of atropine and naloxone on the antinociceptive activity of CT in rodent pain models. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Venoms
3.	Neurotoxins
4.	Cardiotoxins
5.	Cholinergic Antagonists (Anticholinergics)
6.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
7.	Proteins (Proteins, Gene)
8.	Naloxone (Narcan)
9.	Carrier Proteins (Binding Protein)
10.	Atropine

Related Therapies and Procedures

1.	Analgesia
2.	Transplantation
3.	Microspheres (Microsphere)