Coagulase

Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.

Also Known As:

Networked: 3702 relevant articles (74 outcomes, 289 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	De Vliegher, S: 20 articles (01/2017 - 12/2008)
2.	Piepers, S: 14 articles (01/2017 - 07/2009)
3.	Patel, Robin: 12 articles (01/2020 - 10/2004)
4.	Becker, Karsten: 10 articles (01/2022 - 01/2005)
5.	Haesebrouck, F: 10 articles (01/2017 - 12/2008)
6.	Söderquist, B: 10 articles (01/2017 - 01/2006)
7.	Taponen, Suvi: 10 articles (02/2016 - 06/2006)
8.	Barkema, H W: 10 articles (02/2016 - 12/2001)
9.	Fowler, Vance G: 9 articles (01/2018 - 11/2004)
10.	Krediet, Tannette G: 9 articles (11/2012 - 03/2004)

Related Diseases

1.	Infections 06/01/2021 - "Proportions of quarter infections by coagulase-negative Staphylococcus in the treatment group reduced from 16.0% at dry-off to 2.0% post-calving, with a significant reduction in the control group too from 19.1% to 4.3%, which could be due to self-cure. " 01/01/2014 - "Efficacy of vaccination on Staphylococcus aureus and coagulase-negative staphylococci intramammary infection dynamics in 2 dairy herds." 01/01/2013 - "Further work is required to determine if this translates into increased efficacy in preventing infection, particularly against coagulase-negative staphylococci." 07/01/1988 - "The application of newer techniques, such as plasmid analysis and tests for slime production and adherence, contribute to our understanding of the epidemiology and pathogenesis of coagulase-negative staphylococci and may also be helpful in establishing the diagnosis of infection." 01/01/1987 - "[Should mammary infections caused by Corynebacterium bovis and coagulase-negative staphylococci be eliminated?]."
2.	Sepsis (Septicemia) 09/01/2003 - "These results suggest that the VITEK 2 system can provide rapid, accurate, and reliable species-level identification of staphylococci responsible for bloodstream infections, although there is room for improvement in the identification of certain coagulase-negative species, especially S. " 01/01/2022 - "Conclusions This study points to a likely emergence of coagulase-negative Staphylococci as the main cause of sepsis among neonates. " 02/01/2021 - "Coagulase-negative staphylococci was the most common Gram-positive bacteria resulting in bloodstream infection in our study. " 09/01/2019 - "Future research should focus on the feasibility to integrate these tools (individualized dosing, Bayesian models) in clinical practice, and to perform PK/PD studies in the relevant animal models and human neonatal setting (coagulase-negative staphylococci, bloodstream infections)." 01/01/2019 - "In this study, late-onset sepsis was predominantly caused by coagulase negative staphylococci (CoNS) (72%). "
3.	Peritonitis 02/01/2021 - "Over the 18-year period of this study (1995-2011), a total of 878 peritonitis episodes were diagnosed in this unit, 115 were caused by coagulase-negative staphylococci of which 72 by Staphylococcus epidermidis. " 10/01/2004 - "We validate previous studies showing a decrease in the proportion of peritonitis episodes that are caused by coagulase-negative staphylococci. " 10/01/2004 - "Coagulase-negative Staphylococcus was the most common cause of peritonitis (29%), although this rate is lower than in historic studies. " 01/01/2023 - "Patients with PD-associated streptococcus peritonitis (Group S) and patients with coagulase-negative staphylococcus peritonitis (Group CNS) were matched 1:1 as cohort-control groups. " 05/01/2021 - "The Gram-positive peritonitis with Staphylococcus aureus and coagulase-negative Staphylococcus are the most frequent causes, whereas Gram-positive and Gram-negative species remain less frequent. "
4.	Bacteremia 03/01/1998 - "There was a significant reduction in the number of coagulase-negative staphylococcal (CONS) bacteremias (defined as isolation of the same organism from two positive blood cultures) during PN (5 vs. 0; P = 0.037) as well as the total number of bacteremias and fungemias (9 vs. 1; P = 0.036). " 06/01/1990 - "Five bacteremias (two with Streptococcus pneumoniae and one each with Staphylococcus aureus, Proteus mirabilis, and a coagulase-negative staphylococcus) were eradicated. " 11/01/1977 - "None of the six coagulase-negative patients with staphylococcal bacteremia nor any of the 92 controls had titers exceeding 1:1. A total of 10% of the other patients with bacteremia showed positive results on the TAA test at low titer levels. " 05/13/2021 - "The purpose of our study was to investigate the epidemiology of coagulase negative staphylococci (CoNS) responsible for bacteremia in hematopoietic stem cell transplant (HSCT) recipients and to determine the prevalence and the genetic background of methicillin resistance. " 04/01/2020 - "Incidence of coagulase-negative staphylococcal bacteremia among ICU patients: decontamination studies as a natural experiment."
5.	Staphylococcal Infections 03/01/2021 - "Future clinical studies that employ suitable sampling frames coupled with the application of high-resolution whole-genome sequencing may aid the development of more discriminatory diagnostic approaches to coagulase-staphylococcal infection." 02/01/2006 - "During the late study period, there was an increase in coagulase-negative staphylococcus and Staphylococcus aureus infections. " 08/01/2005 - "A meta-analysis of studies performed in developed countries showed a trend of increasing risk for coagulase-negative staphylococcal infection. " 03/01/2003 - "A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units." 11/01/1994 - "Our data corroborate previous studies indicating risk factors and predictors of coagulase-negative staphylococcal infection."

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Vancomycin
3.	Daptomycin
4.	Teicoplanin
5.	Chlorhexidine
6.	Methicillin (Metin)
7.	Oxacillin (Prostaphlin)
8.	Linezolid (Zyvox)
9.	Rifampin (Rifampicin)
10.	Gentamicins (Gentamicin)

Related Therapies and Procedures

1.	Therapeutics
2.	Catheters
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
4.	Length of Stay
5.	Central Venous Catheters