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Cloxacillin (Tegopen)

Subscribe to New Research on Cloxacillin

A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.

Also Known As:

Tegopen; Cloxacillin Sodium; Syntarpen; Cloxacillin, Sodium; Sodium, Cloxacillin; Chloroxacillin; Sodium Cloxacillin; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-

Networked: 321 relevant articles (41 outcomes, 40 trials/studies)

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Drug Context: Research Results

Experts

1.	Tubau, F: 3 articles (07/2012 - 12/2006)
2.	Murillo, O: 3 articles (07/2012 - 12/2006)
3.	Ariza, J: 3 articles (07/2012 - 12/2006)
4.	Ariza, Javier: 2 articles (09/2014 - 01/2004)
5.	Verdaguer, R: 2 articles (07/2012 - 06/2009)
6.	Cabellos, C: 2 articles (07/2012 - 12/2006)
7.	Cabo, J: 2 articles (07/2012 - 06/2009)
8.	Green, M J: 2 articles (02/2011 - 05/2008)
9.	Bradley, A J: 2 articles (02/2011 - 05/2008)
10.	Ako-Nai, A K: 2 articles (12/2009 - 12/2004)

Related Diseases

1.	Infection 12/01/1981 - "No successes were recorded with other drugs, notably cloxacillin, and no infections due to Staphylococcus aureus were eradicated. " 12/01/1983 - "Cloxacillin is effective in staphylococcal CNS infections when used in large parenteral doses." 12/15/1996 - "Of the 37 patients who completed 2-week treatment with cloxacillin, 34 (92%) were cured, and 3 (8%) needed prolonged treatment to cure the infection. " 01/01/2015 - "Prophylactic cloxacillin as a single-dose IV in breast reduction surgery does not reduce the incidence of postoperative infections." 06/01/2012 - "Role of intravenous cloxacillin for inpatient infections."
2.	Endocarditis 07/01/1992 - "At all dosages, cloxacillin was significantly less effective in preventing endocarditis with the tolerant strain than with the nontolerant variant. " 06/01/2014 - "aureus infective endocarditis (IE) treated with cloxacillin. " 03/01/2009 - "We describe a failure of cloxacillin for a patient with endocarditis due to BORSA. " 03/01/1994 - "aureus endocarditis with continuously administered cloxacillin, particularly when high doses of antibiotic are used." 03/01/1994 - "During treatment of endocarditis caused by a tolerant strain, the reduction of bacterial numbers in the infected vegetations decreased significantly with increasing doses of cloxacillin. "
3.	Mastitis 09/01/2009 - "In this study, the effects of prepartum treatment of nonlactating heifers with a 600-mg cloxacillin dry cow treatment on the prevalence of culture-positive milk samples at calving and 10 to 14 d in milk (DIM), the incidence of clinical mastitis, somatic cell count (SCC), and milk production during first lactation were quantified. " 10/01/2010 - "The use of an internal teat sealant in combination with cloxacillin dry cow therapy for the prevention of clinical and subclinical mastitis in seasonal calving dairy cows." 09/01/2009 - "Treatment with cloxacillin 8 to 10 wk before calving resulted in a lower prevalence of culture-positive milk samples at calving and lower quarter milk SCC in early lactation [30,000 +/- 4,600 (standard deviation) cells/mL in treated heifers versus 40,000 +/- 4,600 cells/mL in control heifers], and was associated with lower average test-day SCC (55,000 +/- 1,400 cells/mL in treated heifers versus 71,000 +/- 1,500 cells/mL in control heifers) and lower incidence of clinical mastitis throughout lactation. " 05/24/2008 - "The quarters treated with the internal sealant and cloxacillin were significantly more likely to be bacteriologically negative in the immediate period after calving and were significantly less likely to suffer clinical mastitis during the first 100 days after calving than the quarters treated with cloxacillin alone. " 07/01/2006 - "Mean cloxacillin concentration in untreated quarters was below minimum inhibitory concentrations for targeted mastitis pathogens. "
4.	Staphylococcal Infections 12/01/2010 - "Traditionally, methicillin resistant Staphylococcus aureus (MRSA) is considered as a nosocomial pathogen, but an increasing prevalence of community acquired MRSA is being reported worldwide including India, which implies a strategic change in the antibiotic of choice for treatment of community acquired Staphylococcal infections, which till now is cloxacillin. " 09/26/1964 - "CLOXACILLIN IN THE THERAPY OF STAPHYLOCOCCAL INFECTION." 04/01/2004 - "The hearing thresholds of 12 patients who were treated with teicoplanin for severe staphylococcal infections showed a slight but significant increase over time, whereas the thresholds of 5 patients treated with cloxacillin decreased significantly during treatment. " 08/01/1981 - "An epidemic oc gentamicin/cloxacillin resistant staphylococcal infection in a neonatal unit." 03/01/1964 - "[CLINICAL USE OF A NEW SEMI-SYNTHETIC PENICILLIN (CHLOROXACILLIN) IN STAPHYLOCOCCAL INFECTIONS]."
5.	Bovine Mastitis 05/01/1983 - "Twenty-four isolates of Staphylococcus aureus from naturally occurring cases of bovine mastitis were examined in vitro for resistance to cloxacillin. " 07/01/1969 - "Cloxacillin mastitis ointment in the treatment of bovine mastitis." 04/01/1996 - "Florfenicol did not offer any advantage over cloxacillin in efficacy against bovine mastitis. " 04/01/1996 - "Florfenicol and cloxacillin did not differ significantly in efficacy versus clinical (n = 85) or subclinical (n = 71) bovine mastitis, or for any etiologic agent (X2). " 05/01/1983 - "Penicillin (cloxacillin)-tolerant Staphylococcus aureus from bovine mastitis: identification and lack of correlation between tolerance in vitro and response to therapy in vivo."

Related Drugs and Biologics

1.	Gentamicins (Gentamicin)
2.	Vancomycin
3.	Methicillin (Metin)
4.	Ampicillin (Omnipen)
5.	Penicillins (Penicillin)
6.	Teicoplanin
7.	Rifampin (Rifampicin)
8.	Erythromycin (Erycette)
9.	Clindamycin (Cleocin)
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Craniotomy
2.	Antibiotic Prophylaxis
3.	Neonatal Intensive Care
4.	Cesarean Section (Caesarean Section)
5.	Intravenous Infusions