Clotrimazole (Lotrimin)

An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.

Also Known As:

Networked: 577 relevant articles (80 outcomes, 127 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sola-Penna, Mauro: 4 articles (01/2015 - 04/2005)
2.	Rojanarata, Theerasak: 3 articles (11/2015 - 08/2014)
3.	Ngawhirunpat, Tanasait: 3 articles (11/2015 - 08/2014)
4.	Opanasopit, Praneet: 3 articles (11/2015 - 08/2014)
5.	Tonglairoum, Prasopchai: 3 articles (11/2015 - 08/2014)
6.	Kaomongkolgit, Ruchadaporn: 3 articles (11/2015 - 08/2014)
7.	Hube, Bernhard: 3 articles (07/2015 - 09/2011)
8.	Wilson, Duncan: 3 articles (07/2015 - 09/2011)
9.	Friedman, Michael: 3 articles (03/2015 - 03/2008)
10.	Gati, Irith: 3 articles (03/2015 - 03/2008)

Related Diseases

1.	Infection 06/01/2006 - "Clotrimazole, a fungicidal effective for the local treatment of cutaneous and mucosal infections, was incorporated into solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). " 12/01/1995 - "Clotrimazole, although effective against C albicans infection, also has a deleterious effect on components of the normal vaginal microflora. " 11/01/1986 - "Clotrimazole troches have been previously reported to be effective in the treatment of documented oral Candida infection. " 01/01/2006 - "Both combination kits with local clotrimazole were reasonably effective and safe in the syndromic approach for lower genital infections. " 07/01/2015 - "albicans hyphae are considered the pathogenic morphology during mucosal infections, these data suggest that elevated fungicidal activity of clotrimazole against hyphae plus clotrimazole-induced hyphae-to-yeast reversion may help to dampen acute vaginal infections by reducing the relative proportion of hyphae and thus shifting to a non-invasive commensal-like population. "
2.	Candidiasis (Moniliasis) 01/01/1984 - "The findings indicate that a single 500-mg tablet of clotrimazole is effective and safe in the treatment of vaginal candidiasis and suggest that the efficacy and safety of the one-dose regimen are comparable to those of more prolonged courses with the 100-mg tablet of clotrimazole. " 11/01/1986 - "Clotrimazole is effective in preventing oropharyngeal candidiasis." 07/01/1974 - "A preliminary report on a trial of clotrimazole against vaginal candidiasis in venereology." 07/01/1974 - "An open trial of local therapy with clotrimazole for vaginal candidiasis." 07/01/1974 - "Vaginal candidiasis in pregnancy--a trial of clotrimazole."
3.	Tinea Pedis (Athlete's Foot) 01/01/1977 - "Clotrimazole proved to be effective in the treatment of tinea pedis of both the interdigital and the plantar hyperkeratotic types." 05/01/1979 - "Investigation of clotrimazole usage in tinea pedis without nail involvement." 01/01/1977 - "Topical clotrimazole in tinea pedis." 02/08/2002 - "The Food and Drug Administration (FDA) is issuing a final rule amending the final monograph for over-the-counter (OTC) topical antifungal drug products to add the ingredient clotrimazole as generally recognized as safe and effective for the treatment of athlete's foot, jock itch, and ringworm. " 09/01/2014 - "A synthetic, azole antimycotic, clotrimazole is widely used as a topical treatment for tinea pedis (athlete's foot), as well as vulvovaginal and oropharyngeal candidiasis. "
4.	Oral Candidiasis (Thrush) 11/30/1978 - "We conclude that clotrimazole is highly effective treatment for chronic oral candidiasis." 03/01/2015 - "The novel clotrimazole sustained release varnish may be an important part of a new protocol for oral candidiasis, with improved clinical outcomes." 03/01/2015 - "Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis." 02/01/1984 - "Clotrimazole troches are effective in preventing oral candidiasis in a select group of patients." 03/01/2015 - "The aim of this study was to compare the efficacy of this varnish with clotrimazole troche treatment of oral candidiasis. "
5.	Vulvovaginal Candidiasis 01/01/1986 - "The findings indicate that a single 500-mg tablet of clotrimazole is as effective and safe in the treatment of vulvovaginal candidiasis as a three-day course of 200 mg/day." 08/01/1985 - "Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis." 01/01/1978 - "An open trial of local clotrimazole therapy in 56 pregnant women with vulvovaginal candidiasis is reported. " 10/01/2013 - "The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. " 04/01/1994 - "To determine the comparative efficacy and cost benefit of prophylactic monthly (perimenstrual) clotrimazole, versus empiric self-treatment with the same agent at the onset of symptoms in recurrent vulvovaginal candidiasis. "

Related Drugs and Biologics

1.	Fluconazole (Zonal)
2.	Vaginal Creams, Foams, and Jellies (Vaginal Tablet)
3.	Ketoconazole (Nizoral)
4.	Itraconazole (Sporanox)
5.	Miconazole (Monistat)
6.	terbinafine (Lamisil)
7.	Amphotericin B (Amphotericin)
8.	Nystatin (Mycostatin)
9.	Clotrimazole (Lotrimin)
10.	Econazole

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Pessaries
3.	Complementary Therapies (Alternative Medicine)
4.	Topical Administration
5.	Drug Therapy (Chemotherapy)