Clorazepate Dipotassium (Tranxene)

A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.

Also Known As:

Tranxene; 4306-CB; Clorazepate; Clorazepate Monopotassium; Clorazepic Acid; Tranxilium; Chlorazepate; Dipotassium Chlorazepate; 1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, monopotassium salt, compd. with potassium hydroxide (K(OH)) (1:1)

Networked: 94 relevant articles (13 outcomes, 10 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Clorazepate Dipotassium: 94
        Noctran

Experts

1.	Ikeda, Hiroko: 2 articles (12/2014 - 11/2012)
2.	Chen, Jih-Jung: 1 article (11/2016)
3.	Hung, Dong-Zong: 1 article (11/2016)
4.	Lee, Ying-Ray: 1 article (11/2016)
5.	Li, Yi-Wen: 1 article (11/2016)
6.	Lim, Yun-Ping: 1 article (11/2016)
7.	Lin, Cheng-Li: 1 article (11/2016)
8.	Lin, Yen-Ning: 1 article (11/2016)
9.	Wang, Charles-C N: 1 article (11/2016)
10.	Inoue, Shuko: 1 article (01/2015)

Related Diseases

1.	Seizures (Absence Seizure) 06/01/1987 - "This complete absence of seizures suggests that clorazepate is effective in counteracting convulsive and other manifestations of the alcohol withdrawal syndrome." 01/01/1984 - "The results of this study indicate the efficacy of clorazepate for epileptic children with refractory seizures." 12/03/1999 - "Dipotassium clorazepate suppressed amygdaloid-kindled seizures at 2 and 5 mg/kg, while 1 mg/kg or more suppressed hippocampal-kindled seizures. " 12/03/1999 - "Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats." 08/01/1998 - "Dipotassium clorazepate was administered intraperitoneally in rats that showed two stable stage 5 seizures induced at the GST current intensity. "
2.	Anxiety Disorders (Anxiety Disorder) 05/01/1988 - "The authors conclude that clorazepate is effective in treating depressive symptoms and improving intellectual functioning in patients with generalized anxiety disorder." 06/22/1987 - "Patients with generalized anxiety disorder (n = 18) entered a 21-day, double-blind, placebo-controlled random assignment trial of clorazepate. " 01/01/1987 - "A double-blind, placebo-controlled study of clorazepate in the treatment of 189 patients diagnosed with generalized anxiety disorder was conducted to evaluate the efficacy of an anxiolytic on the depressed-mood component of anxiety. " 03/01/2014 - "The effectiveness of clorazepate dipotassium combined with fluoxetine and a behaviour modification programme for the treatment of anxiety disorders in dogs was investigated. " 08/01/1985 - "The regional cerebral effects of an anxiolytic (clorazepate) in 20 patients with generalized anxiety disorder were assessed using 16-channel electroencephalogram (EEG) power spectral estimate maps of the left hemisphere. "
3.	Psychotic Disorders (Schizoaffective Disorder) 03/01/1987 - "It is concluded that clorazepate may be a useful treatment for some cases of chronic psychosis and psychotic misidentification. " 03/01/1987 - "A patient with chronic psychosis and intermittent psychotic misidentification of the Capgras and intermetamorphosis types refractory to neuroleptic treatment was given a trial of clorazepate. " 11/01/1997 - "Clorazepate dipotassium (Tranxene), benzodiazepine of retarded anxiety-relieving, sedative and sleep-inducing action was used in an open sample of 36 patients for fast control of anxiety and aggression in the course of schizophrenia, schizoaffective psychosis and other psychotic disorders. "
4.	Glaucoma 08/01/1978 - "[Chlorazepate and glaucomas]." 09/01/1972 - "[Acute glaucoma episode improved by a benzodiazepine: dipotassic clorazepate]."
5.	Adjustment Disorders (Adjustment Disorder) 09/01/1999 - "The efficacy of trazodone and clorazepate to relieve anxiety and depressive symptoms in 21 HIV-positive subjects with adjustment disorders was determined in a 28-day single-centre, randomized, double-blind study. " 09/01/1999 - "Efficacy and safety of trazodone versus clorazepate in the treatment of HIV-positive subjects with adjustment disorders: a pilot study." 01/01/1999 - "Trazodone is devoid of an abuse risk and dependence and, therefore, could be a valuable alternative to clorazepate in the treatment of adjustment disorders in cancer patients." 01/01/1999 - "Comparative study of the efficacy and safety of trazodone versus clorazepate in the treatment of adjustment disorders in cancer patients: a pilot study."

Related Drugs and Biologics

1.	Valproic Acid (Depakote)
2.	Trazodone (Trittico)
3.	Anti-Anxiety Agents (Anxiolytics)
4.	Benzodiazepines
5.	methsuximide (mesuximide)
6.	Clonazepam (Rivotril)
7.	Phenobarbital (Luminal)
8.	Clobazam (HR 376)
9.	Midazolam (Versed)
10.	Zonisamide (Zonegran)

Related Therapies and Procedures

1.	Therapeutics
2.	Premedication
3.	Vagus Nerve Stimulation
4.	Intravenous Injections
5.	Injections