Clonorchiasis

Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)

Also Known As:

Networked: 185 relevant articles (14 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Paragonimiasis
3.	Helminthiasis (Helminthiases)
4.	Neurocysticercosis
5.	Schistosomiasis (Bilharziasis)

Experts

1.	Yu, Xinbing: 23 articles (07/2015 - 07/2007)
2.	Hu, Xuchu: 16 articles (06/2014 - 07/2007)
3.	Hong, Sung-Tae: 16 articles (06/2013 - 06/2002)
4.	Xu, Jin: 15 articles (03/2015 - 07/2007)
5.	Huang, Yan: 13 articles (07/2015 - 08/2007)
6.	Choi, Min-Ho: 12 articles (03/2011 - 06/2002)
7.	Wu, Zhongdao: 11 articles (01/2014 - 07/2007)
8.	Li, Xuerong: 9 articles (03/2015 - 01/2011)
9.	Chen, Wenjun: 7 articles (01/2015 - 01/2011)
10.	Liang, Chi: 7 articles (06/2014 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Clonorchiasis:

1.	Praziquantel (Biltricide)FDA Link 01/01/2010 - "Repeated mass treatment or selective treatment with praziquantel every 6 to 12 months is highly effective for clonorchiasis control in heavily endemic areas. " 07/01/1992 - "Analysis of five therapeutic schemes used in clonorchiasis, making use of chloxilin, medamin or praziquantel, has demonstrated a low efficacy of all of them. " 07/15/2004 - "ENBD combined with oral praziquantel is an effective and safe method for the treatment of severe Clonorchiasis sinensis." 12/01/2001 - "The present study aimed to evaluate control efficacy of clonorchiasis by two schemes of repeated treatment with praziquantel at two endemic villages in China. " 02/01/1987 - "Clinical study evaluating efficacy of praziquantel in clonorchiasis."
2.	Albendazole (Albenza)FDA Link 01/01/1991 - "Experimental and clinical trial of albendazole in the treatment of Clonorchiasis sinensis." 06/01/1985 - "[Treatment of clonorchiasis sinensis with albendazole: 50 cases]." 01/01/1995 - "This paper reported on the clinical efficacy of praziquantel-albendazole combination in the treatment of clonorchiasis in Guangxi. " 01/01/1995 - "[Efficacy of praziquantel combined with albendazole in the treatment of clonorchiasis]." 10/01/2005 - "The minimum effective dosages were a single dose of praziquantel 375 mg/kg, albendazole 150 mg/kg, and mebendazole 150 mg/kg. Trials are required to determine whether these dosages are useful in the treatment of human clonorchiasis."
3.	AntigensIBA 10/01/2012 - "The combined results from the present study indicate that CsLAP2 was an important antigen exposed to host immune system, and probably implicated as potential role in interaction with host cells in clonorchiasis." 08/01/1992 - "In this present study, adult worm antigen of Clonorchis sinensis and the indirect and double sandwich enzyme linked immunosorbent assay (ELISA) were used to detect the serum antibody of clonorchiasis patients from the endemic area of Miao-Li county. " 04/01/1964 - "[STUDIES ON THE FRACTIONATION OF CLONORCHIASIS ANTIGEN RESPONSIBLE FOR THE INTRADERMAL SKIN REACTION]." 07/01/2015 - "subtilis spore as an ideal vehicle for antigen delivery by oral treatment and CsENO as a promising vaccine candidate against clonorchiasis. " 05/01/2015 - "Previously, we have identified that CsPmy reacted with sera of human clonorchiasis and this protein had a potential as a candidate antigen for serodiagnosis of clonorchiasis. "
4.	tribendimidineIBA 04/01/2013 - "sinensis-infected patients to determine the potential of tribendimidine against clonorchiasis and other helminthiases. " 04/01/2008 - "The in vivo results presented here with the artemisinins and tribendimidine provide further data for clinical investigations to assess the safety and efficacy of these drugs in clonorchiasis patients." 03/01/2012 - "Praziquantel is the major chemotherapeutic agent for clonorchiasis and recently tribendimidine was found effective and is now under investigation as a promising chemotherapeutic alternative. " 06/30/2010 - "The doses of tribendimidine, artesunate and praziquantel used in clinical treatment of clonorchiasis were converted to the doses used in rats by the method of equal effective dose conversion among different animals, while the administration regimens of the drugs were designed basing on the regimens used in clinical trials. " 06/30/2010 - "To evaluate the efficacy in treatment of Clonorchis sinensis-infected rats using the administration regimens of tribendimidine, artesunate and praziquantel applied in clinical treatment of clonorchiasis. "
5.	Mebendazole (Vermin)FDA Link 10/01/2005 - "The minimum effective dosages were a single dose of praziquantel 375 mg/kg, albendazole 150 mg/kg, and mebendazole 150 mg/kg. Trials are required to determine whether these dosages are useful in the treatment of human clonorchiasis."
6.	azinoxIBA 01/01/1993 - "[The first trial of azinox treatment in a clonorchiasis focus in the Socialist Republic of Vietnam]." 01/01/1993 - "Trials of biltricide (Merck, India) and azinox, its analog manufactured in this country, carried out in a mixed focus of clonorchiasis and intestinal nematodiases in Vietnam, have not shown any noticeable difference in the efficacy and tolerance of these drugs, that were administered for 3 days in total doses of 60 and 75 mg/kg. The mean efficacy of clonorchiasis therapy was 59.2%, and the invasion intensity reduced by more than 98%. "
7.	AntibodiesIBA 01/01/2001 - "To establish a new, fast, sensitive and specific assay for detecting antibodies in clonorchiasis. " 01/01/2001 - "[Application of dot immunogold filtration assay for detecting serum antibodies in clonorchiasis patients]." 04/01/1981 - "[Irregular anti-P1 allo-antibodies and sinensis clonorchiasis]." 03/01/1995 - "Antibodies in serum of patients with clonorchiasis before and after treatment." 08/01/2013 - "To locate antigenic determinants, the pooled sera of clonorchiasis patients and healthy persons were analyzed for specific antibodies by ELISA with recombinant protein rCs22M-2r and rCs22M-3r containing the tandem repeat sequences. "
8.	Chloroquine (Aralen)FDA LinkGeneric 06/01/1957 - "Chloroquine in the treatment of clonorchiasis; a report of 90 cases." 01/01/1955 - "Treatment of clonorchiasis with chloroquine and methiscol." 01/01/1955 - "Immunodiagnosis and chemotherapy of Clonorchiasis sinensis, with especial reference to efficacy of chloroquine including a note on negative effect of oxychloroquine." 01/01/1955 - "[Intramuscular chloroquine and emetine in the treatment of amebiasis, fascioliasis and clonorchiasis]."
9.	ArtemisininsIBA 04/01/2008 - "The in vivo results presented here with the artemisinins and tribendimidine provide further data for clinical investigations to assess the safety and efficacy of these drugs in clonorchiasis patients."
10.	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/01/1955 - "Immunodiagnosis and chemotherapy of Clonorchiasis sinensis, with especial reference to efficacy of chloroquine including a note on negative effect of oxychloroquine."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/2005 - "Extensive studies of clonorchiasis during several decades in Japan, Korea, China and other countries have shown much progress in proving its morphological features including ultrastructure, biology, pathogenesis, epidemiology, clinical manifestations and chemotherapy. " 03/01/2012 - "Any evidence of clonorchiasis, such as eggs, DNAs, or images, may lead to recommendations of chemotherapy in endemic areas. " 05/01/2009 - "We performed a comparative cost estimation of three different diagnostic and intervention approaches in areas of high and low prevalence of clonorchiasis in northern Vietnam in order to select more cost-effective chemotherapy. " 04/30/2004 - "[A comparative investigation on chemotherapy in the control of clonorchiasis]." 01/01/1980 - "Chemotherapy of opistorchiasis and clonorchiasis is still unsatisfactory. "
2.	Aftercare (After-Treatment) 06/01/1999 - "To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. " 03/01/2009 - "In a heavy endemic area, the sonographic finding of FEFGB may suggest active clonorchiasis 1 year after treatment." 03/01/2009 - "Changes in sonographic findings after treatment of patients with clonorchiasis in a heavy endemic area." 07/01/2003 - "Experimental clonorchiasis in dogs: CT findings before and after treatment." 03/01/1995 - "Antibodies in serum of patients with clonorchiasis before and after treatment."
3.	Individualized Medicine 10/01/2014 - "The molecular diversity of the parasitic PLA2 described in this study provides a platform for personalized medicine in the therapeutics of clonorchiasis. "
4.	Therapeutics 10/01/2014 - "The molecular diversity of the parasitic PLA2 described in this study provides a platform for personalized medicine in the therapeutics of clonorchiasis. "
5.	Investigational Therapies (Experimental Therapy) 05/01/1964 - "[ON EXPERIMENTAL THERAPY OF CLONORCHIASIS WITH HEXACHLORO-P-XYLOL. "