Clonazepam (Rivotril)

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.

Also Known As:

Networked: 1072 relevant articles (181 outcomes, 127 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Luszczki, Jarogniew J: 14 articles (07/2014 - 05/2003)
2.	Czuczwar, Stanislaw J: 9 articles (12/2011 - 05/2003)
3.	Borowicz, Kinga K: 8 articles (12/2015 - 04/2002)
4.	Czuczwar, Stanisław J: 8 articles (03/2009 - 04/2002)
5.	Nardi, Antonio E: 7 articles (03/2013 - 11/2002)
6.	Nascimento, Isabella: 7 articles (02/2012 - 06/2002)
7.	Czuczwar, S J: 7 articles (07/2005 - 01/2000)
8.	Valença, Alexandre M: 6 articles (02/2012 - 06/2002)
9.	Versiani, Marcio: 6 articles (02/2012 - 11/2002)
10.	Borowicz, K K: 6 articles (07/2005 - 01/2000)

Related Diseases

1.	Seizures (Seizure) 06/01/1975 - "Evaluation of seizure control by clonazepam showed that the large majority of patients had improved--complete control of seizures was achieved in 27 per cent, and a greater than 50 per cent control was achieved in 61 per cent of the patients. " 01/01/2003 - "Thus in this study of the acute effects of a low-dose level of clonazepam on seizure frequency a significant reduction was found at plasma levels below those usually recommended. " 07/01/2005 - "The combined treatment of AGLD (5 mg/kg) and clonazepam (CLO) at its subeffective dose of 0.01 mg/kg caused significant reduction of the seizure severity, seizure duration and afterdischarge duration. " 01/01/2003 - "A significant reduction of seizures (P = 0.0031) at median maximal plasma levels of clonazepam of 23 nmol/L (range = 11-41 nmol/L) was found. " 01/01/1980 - "A therapeutic trial with clonazepam substantially reduced the frequency of reflex-induced and spontaneous seizures."
2.	Myoclonus (Nocturnal Myoclonus) 06/01/2007 - "Subsequent therapy with low-dose clonazepam was highly effective in reducing myoclonic jerks and exaggerated startle reaction, and unlike previously used drugs, it was decisive in reducing hypertonia." 01/01/1986 - "Clonazepam improved myoclonus in 10 of 13 patients, two of whom had complete resolution of symptoms. " 03/01/1977 - "Clonazepam is very effective in controlling the myoclonus. " 02/01/1988 - "Clonazepam was effective in controlling the myoclonic jerks, which were a feature in this patient, without producing excessive sedation. " 01/01/2011 - "Clonazepam may be helpful with all types of myoclonus. "
3.	Panic Disorder (Panic Attack) 03/05/2003 - "In the group that received clonazepam, by the end of the 6th week there was a statistically significant clinical improvement, shown by the remission of panic attacks (p < 0.001) and decrease in anxiety (p = 0.024). " 03/05/2003 - "Clonazepam was equally effective in the treatment of the respiratory and non-respiratory subtypes of panic disorder, suggesting there is no difference in the therapeutic response between the two subtypes." 05/01/1991 - "Clonazepam was administered in relatively low doses and, after four weeks, was shown to be effective in reducing the number of panic attacks and associated features of the disorder." 05/01/2006 - "The efficacy of clonazepam monotherapy for the short-term treatment of panic disorder (PD) was fully established in two large pivotal multicentre studies in the late 1990s in a total of >800 patients. " 03/05/2003 - "To evaluate the clinical efficacy of clonazepam in a fixed dosage (2 mg/day), compared to placebo, in the treatment of panic disorder patients and to verify whether there are any differences in the responses to clonazepam between panic disorder patients with the respiratory and non-respiratory subtypes. "
4.	Tremor (Tremors) 01/01/1996 - "He was then treated with gradually increasing doses of clonazepam; when he received 8 mg/day of clonazepam, his tremor showed marked improvement. " 10/31/2007 - "Patients with fast tremor improved on clonazepam. " 02/01/2002 - "Clonazepam is the first-line treatment for orthostatic tremor. " 01/01/1998 - "Clonazepam was used in an open study in 11 MS patients to evaluate the sensitivity of TREMOR, compared to the clinical observations. " 07/01/2012 - "Clonazepam in the treatment of essential palatal tremors."
5.	Bipolar Disorder (Mania) 12/24/1995 - "This study was performed to evaluate the optimal doses and clinical efficacy of clonazepam as a first-line drug in acute mania, as well as to determine its effective plasma concentrations. " 10/01/1987 - "This is a report on the efficacy of clonazepam in the treatment of acute mania. " 10/01/1999 - "[A trial of clonazepam treatment for manic-depressive psychoses]." 06/01/1991 - "Clonazepam in acute mania: a double blind trial." 05/01/2006 - "Finally, evidence for the use of clonazepam in acute mania and as augmentation therapy with SSRIs to accelerate response in depression is examined. "

Related Drugs and Biologics

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2.	Phenobarbital (Luminal)
3.	Benzodiazepines
4.	Carbamazepine (Tegretol)
5.	Alprazolam (Xanax)
6.	Diazepam (Valium)
7.	Anticonvulsants (Antiepileptic Drugs)
8.	Pentylenetetrazole (Metrazol)
9.	etiracetam (levetiracetam)
10.	Lithium

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Oral Administration
4.	Continuous Positive Airway Pressure
5.	Occlusal Splints