Clomipramine (Anafranil)

A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.

Also Known As:

Networked: 872 relevant articles (118 outcomes, 182 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Gorenstein, Clarice: 5 articles (01/2015 - 03/2002)
2.	Eschalier, A: 5 articles (06/2011 - 03/2001)
3.	Marcourakis, Tania: 4 articles (01/2015 - 03/2002)
4.	Hollander, Eric: 4 articles (04/2006 - 10/2002)
5.	Oktem, Gulperi: 3 articles (01/2014 - 04/2008)
6.	Bilir, Ayhan: 3 articles (01/2014 - 04/2008)
7.	Baez, Alejandra: 3 articles (06/2013 - 10/2010)
8.	Markianos, M: 3 articles (01/2011 - 07/2000)
9.	Rivarola, H W: 3 articles (10/2005 - 09/2001)
10.	Liebowitz, Michael R: 3 articles (01/2005 - 01/2004)

Related Diseases

1.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 06/01/1987 - "Most of the controlled studies on the efficacy of medical treatments of obsessive-compulsive disorder (OCD) have involved clomipramine, a tricyclic antidepressant reputed to have anti-obsessional properties. " 05/01/1979 - "The authors believe that chlorimipramine is the most promising treatment for obsessive-compulsive neurosis." 03/01/1997 - "Intravenous pulse loading of clomipramine may be a valuable new treatment for obsessive-compulsive disorder, particularly for patients who have failed oral treatment trials." 05/01/2004 - "Review: clomipramine is more effective than SSRIs for paediatric obsessive compulsive disorder." 03/01/1992 - "In conjunction with the tricyclic antidepressant clomipramine, behavioural therapy is superior to other psychotherapeutic strategies in the treatment of obsessive-compulsive disorders. "
2.	Panic Disorder (Panic Attack) 09/01/1981 - "These results support the claim that chlomipramine is highly effective in preventing recurrence of panic attacks." 05/01/1998 - "These results suggest that regular aerobic exercise alone, in comparison with placebo, is associated with significant clinical improvement in patients suffering from panic disorder, but that it is less effective than treatment with clomipramine." 05/01/1991 - "Clomipramine at low doses is also effective in the treatment of panic disorder and has been used successfully in the treatment of premature ejaculation." 01/01/1999 - "Several placebo-controlled trials have shown the efficacy of clomipramine (CMI) in panic disorder. " 01/01/1993 - "[The clinico-psychopathological characteristics of patients with panic disorders and the efficacy of clomipramine therapy]."
3.	Pain (Aches) 12/01/2009 - "In patients with chronic non-malignant pain, clomipramine is superior to placebo as regards anxiolytic effect measured by Spielberger State Anxiety Symptom Scale (SSASS). " 01/01/1987 - "The results of this study indicate that clomipramine, often used in chronic pain as an adjuvant drug, exerts as well as analgesic effect in acute pain." 01/01/1985 - "This study also indicates a "therapeutic window" of plasma levels between 20 and 85 ng/ml. These results permit discussion of measurement of plasma levels of clomipramine in the treatment of chronic pain." 01/01/1982 - "By taking into account recent anatomical, biochemical and pharmacological studies, it can be concluded that clomipramine probably has-in addition to the action on peripheral receptors-a direct effect upon pain modulation systems. " 01/01/1980 - "Comparative trial of clomipramine and placebo in the treatment of terminal pain."
4.	Agoraphobia 05/01/1988 - "The efficacy of clomipramine hydrochloride in the treatment of agoraphobia was investigated in an eight-week placebo-controlled double-blind study. " 02/01/1989 - "Seventeen outpatients with panic anxiety and agoraphobia were treated with a low, flexible dose of clomipramine in an 8-week open trial. " 12/01/1993 - "The authors examined the effects of clomipramine on agoraphobia in patients who failed to respond to exposure-based behavioral treatment. " 07/01/1990 - "A case is presented of a patient with severe panic disorder and agoraphobia in whom initial treatment with clomipramine resulted in complete elimination of panic attacks, with no improvement in agoraphobic avoidance. " 09/01/2002 - "This study investigated the chronic use (6.3 +/- 0.5 years; mean +/- SEM) of therapeutic doses of clomipramine (57.0 +/- 8.0 mg/day) by outpatients with panic disorder/agoraphobia who were currently in remission to assess impairment of memory and psychomotor functions. "
5.	Cataplexy 02/01/2002 - "Clomipramine is an effective treatment of cataplexy. " 01/01/1985 - "Treatment of excessive daytime somnolence is still primarily based upon CNS stimulants while treatment of cataplexy and other related symptoms rests on chlorimipramine. " 07/01/1979 - "Clomipramine hydrochloride effectively controlled the cataplexy and partially alleviated the daytime sleep attacks. " 07/01/1979 - "Severe hypermotility during sleep in treatment of cataplexy with clomipramine." 01/01/1974 - "Treatment of cataplexy with clomipramine."

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)
3.	Desipramine (Pertofrane)
4.	Fluoxetine (Prozac)
5.	Imipramine (Janimine)
6.	Fluvoxamine (Luvox)
7.	Antidepressive Agents (Antidepressants)
8.	Clomipramine (Anafranil)
9.	Norepinephrine (Noradrenaline)
10.	Paroxetine (Paxil)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Oral Administration
4.	Nerve Block (Nerve Blocks)
5.	Injections