Clofazimine (Lamprene)

A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)

Also Known As:

Networked: 463 relevant articles (44 outcomes, 54 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lu, Yu: 6 articles (01/2014 - 10/2008)
2.	Wang, Bin: 6 articles (01/2014 - 10/2008)
3.	Grosset, Jacques H: 4 articles (06/2015 - 09/2013)
4.	Ma, Zhenkun: 4 articles (01/2014 - 11/2011)
5.	Huang, Haihong: 4 articles (01/2014 - 11/2011)
6.	Fu, Lei: 4 articles (01/2014 - 09/2009)
7.	Yin, Dali: 4 articles (01/2014 - 11/2011)
8.	van Rensburg, C E: 4 articles (09/2001 - 01/2000)
9.	Nuermberger, Eric L: 3 articles (06/2015 - 05/2013)
10.	Adamson, John: 3 articles (06/2015 - 01/2015)

Related Diseases

1.	Infection 08/01/1996 - "The data demonstrate that liposomal clofazimine is highly effective in the treatment of MAC infections, even if the treatment is initiated after a disseminated infection has been established. " 10/01/1989 - "In vivo, only clofazimine displayed significant activity, and it was most effective against the cutaneous infections. " 01/01/2000 - "Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection." 01/01/1997 - "The therapeutic efficacy of liposomal clofazimine (L-CLF) against Mycobacterium avium complex (MAC) was evaluated in the acute and chronic infection models of the beige mouse (C57BL/6J bgj bgj). " 01/01/1997 - "Therapeutic efficacy of liposomal clofazimine against Mycobacterium avium complex in mice depends on size of initial inoculum and duration of infection."
2.	Leprosy (Hansen's Disease) 05/01/1991 - "Clinical studies support the efficacy of clofazimine as a part of multidrug therapy in treating leprosy. " 08/01/2012 - "Clofazimine, a fat-soluble dye with experimental activity against TB, but used only for leprosy in the last 50 years, requires further study because it has been included in a successful short 9-month combined drug regimen for the treatment of multidrug-resistant TB. " 03/01/1994 - "Our study, therefore, was designed to assess the changes that might be seen in the lymphatic system of patients treated with clofazimine for the management of leprosy. " 01/01/1966 - "Further studies on B.663 in murine leprosy. " 09/01/2015 - "Clofazimine (CFZ) is an optically active, red-colored chemotherapeutic agent that is FDA approved for the treatment of leprosy and is on the World Health Organization's list of essential medications. "
3.	Acquired Immunodeficiency Syndrome (AIDS) 02/01/1997 - "Pulmonary clofazimine crystals in two patients with the acquired immunodeficiency syndrome." 05/01/1992 - "Although this is the first observation at San Francisco (Calif) General Hospital of clofazimine crystals in a respiratory specimen from a patient with AIDS, the potential of more widespread therapy with clofazimine in patients with AIDS who are infected with M avium complex makes it imperative that the microscopic appearance of these crystals be recognized." 05/01/1992 - "Clofazimine crystals in alveolar macrophages from a patient with the acquired immunodeficiency syndrome." 05/01/1991 - "Efficacy in treating MAC infection in patients with AIDS is not well documented, despite the use of clofazimine in combination with other agents. " 10/01/1993 - "We report a case of negative images due to crystalline deposition of clofazimine, a drug used to treat Mycobacterium avium-intracellulare complex infection in AIDS patients. "
4.	Tuberculosis (Tuberculoses) 11/01/2011 - "Most importantly, the nine compounds that progressed to efficacy testing demonstrated inhibition of bacterial growth in the lungs that is superior to the activity of an equivalent dose of clofazimine when administered orally for 20 days in a murine model of acute tuberculosis. " 06/01/2015 - "Based on evidence of efficacy of clofazimine (CFZ) in humans and mice with tuberculosis, we hypothesized that the combination of RIF+CFZ would be effective against M. " 11/01/2011 - "Clofazimine analogs with efficacy against experimental tuberculosis and reduced potential for accumulation." 01/01/2015 - "Our objective was to conduct a preclinical evaluation of the pharmacokinetics and pharmacodynamics of clofazimine in the mouse model of tuberculosis, with the goal of providing useful information on dosing for future studies. " 01/01/1988 - "These studies indicate important mechanisms operative in the pathogenesis of tuberculosis and suggest that clofazimine may have clinical relevance in the treatment of mycobacterial diseases."
5.	Crohn Disease (Crohn's Disease) 06/01/1993 - "the efficacy of Lamprene in ano-perineal lesions of Crohn's disease is possible and is worthy of evaluation in a controlled trial." 06/01/1993 - "[Lamprene in ano-perineal lesions of Crohn's disease. " 04/01/1991 - "Clofazimine as a solitary antimycobacterial agent appears ineffective in inducing remission in Crohn's disease but may have a role in either disease maintenance or combination chemotherapy." 02/15/2010 - "Long-term treatment with nitroimidazoles or clofazimine appears to be effective in patients with Crohn's disease." 06/01/1993 - "The efficacy of clofazimine (Lamprene) was analysed retrospectively in twenty one patients with anoperineal lesions (APL) of Crohn's disease. "

Related Drugs and Biologics

1.	Rifampin (Rifampicin)
2.	Ethambutol (Myambutol)
3.	Rifabutin (Ansamycin)
4.	Clarithromycin (Biaxin)
5.	Dapsone
6.	Isoniazid (Ftivazide)
7.	Clofazimine (Lamprene)
8.	Streptomycin (Streptomycin Sulfate)
9.	Macrolides
10.	Steroids

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Laparotomy
4.	Transplants (Transplant)
5.	Lasers (Laser)