Clofazimine (Lamprene)

A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)

Also Known As:

Lamprene; B663; B-663; G-30,320; N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)-2-phenazinamine; B 663; G 30,320; G30,320; 2-Phenazinamine, N,5-bis(4-chlorophenyl)-3,5-dihydro-3-((1-methylethyl)imino)-

Networked: 767 relevant articles (76 outcomes, 95 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenazines: 42
      - Clofazimine: 767
        B 669: 8
        B1912: 3
        B 4121: 1
        B 4154: 1
        B 4157: 1
        B 746: 1
        3-(4-hydroxyanilino)-10-(4-chlorophenyl)-2,10-dihydro-2-isopropyliminophenazine
        3-(beta-D-glucopyranosiduronic acid)-10-(4-chlorophenyl)-2,10-dihydro-2-isopropyliminophenazine
        B 1056
        B 749
        B 775

Experts

1.	Lu, Yu: 12 articles (01/2021 - 10/2008)
2.	Ammerman, Nicole C: 10 articles (12/2021 - 09/2013)
3.	Rosania, Gus R: 10 articles (12/2021 - 03/2013)
4.	Wang, Bin: 10 articles (01/2021 - 10/2008)
5.	Stringer, Kathleen A: 9 articles (12/2021 - 03/2013)
6.	Almeida, Deepak V: 9 articles (01/2019 - 09/2013)
7.	Grosset, Jacques H: 9 articles (01/2019 - 09/2013)
8.	Fu, Lei: 8 articles (01/2021 - 09/2009)
9.	Huang, Haihong: 7 articles (01/2021 - 11/2011)
10.	Pang, Yu: 6 articles (01/2021 - 01/2015)

Related Diseases

1.	Leprosy (Hansen's Disease) 01/01/2023 - "Clofazimine (P score=0.9141) and dapsone+rifampicin (P score=0.8785) were effective for treating type 2 leprosy reaction. " 01/01/2016 - "The present study evaluated the growth-inhibitory effects of clofazimine, currently used for treating leprosy, against Babesia bovis, B. " 03/01/1994 - "Our study, therefore, was designed to assess the changes that might be seen in the lymphatic system of patients treated with clofazimine for the management of leprosy. " 01/01/1966 - "Further studies on B.663 in murine leprosy. " 01/01/1965 - "TREATMENT OF LEPROSY WITH B 663 APPRAISAL OF THE PILOT TRIAL AFTER THREE YEARS."
2.	Infections 08/01/1996 - "The data demonstrate that liposomal clofazimine is highly effective in the treatment of MAC infections, even if the treatment is initiated after a disseminated infection has been established. " 10/01/1989 - "In vivo, only clofazimine displayed significant activity, and it was most effective against the cutaneous infections. " 01/01/2017 - "We further demonstrate that the efficacy of a clinically used compound, clofazimine, is augmented by pH-based partitioning in a macrophage infection model. " 01/01/2000 - "Preparation of a clofazimine nanosuspension for intravenous use and evaluation of its therapeutic efficacy in murine Mycobacterium avium infection." 01/01/1997 - "Therapeutic efficacy of liposomal clofazimine against Mycobacterium avium complex in mice depends on size of initial inoculum and duration of infection."
3.	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 02/01/2019 - "We carried out a randomized multicentre study in China to investigate whether the clofazimine would improve the efficacy of the standardized regimen in patients with multidrug-resistant tuberculosis (MDR-TB). " 01/01/2023 - "This study demonstrated that compared with patients who do not receive clofazimine, this drug has the potential to achieve a higher favorable outcome, treatment completion and cure rates, and a lower treatment failure risk among drug-resistant tuberculosis cases." 01/01/2020 - "Treatment Outcome of a Shorter Regimen Containing Clofazimine for Multidrug-resistant Tuberculosis: A Randomized Control Trial in China." 05/01/2015 - "Clofazimine for the treatment of multidrug-resistant tuberculosis: prospective, multicenter, randomized controlled study in China." 09/01/2013 - "Although observational studies suggest that clofazimine-containing regimens are highly active against drug-resistant tuberculosis, the contribution of clofazimine for the treatment of this disease has never been systematically evaluated. "
4.	Tuberculosis (Tuberculoses) 11/01/2011 - "Most importantly, the nine compounds that progressed to efficacy testing demonstrated inhibition of bacterial growth in the lungs that is superior to the activity of an equivalent dose of clofazimine when administered orally for 20 days in a murine model of acute tuberculosis. " 01/01/2015 - "Based on evidence of efficacy of clofazimine (CFZ) in humans and mice with tuberculosis, we hypothesized that the combination of RIF+CFZ would be effective against M. " 11/01/2011 - "Clofazimine analogs with efficacy against experimental tuberculosis and reduced potential for accumulation." 01/01/2021 - "Fifteen adults drug-susceptible tuberculosis patients received clofazimine monotherapy as 300 mg daily for 3 days, followed by 100 mg daily in one arm of a 2-week, multiarm early bactericidal activity trial in South Africa. " 01/01/2016 - "Experimental and clinical studies have indicated that the antileprosy drug clofazimine may contribute treatment-shortening activity when included in tuberculosis treatment regimens. "
5.	Cryptosporidiosis 01/01/2022 - "Initially identified by a large-scale phenotypic screening campaign, the antimycobacterial therapeutic clofazimine demonstrated great promise in both in vitro and in vivo preclinical models of Cryptosporidium infection. " 01/01/2022 - "It is unlikely that clofazimine will provide a remedy for the large number of cryptosporidiosis patients currently without a viable treatment option unless alternative, safe clofazimine formulations with improved oral absorption are developed. " 01/01/2023 - "The CRYPTOFAZ trial, previously published, was conducted in Malawi to evaluate the efficacy of clofazimine in response to an unmet need for drugs to treat cryptosporidiosis in HIV populations. " 08/23/2018 - "Evaluating the safety, tolerability, pharmacokinetics and efficacy of clofazimine in cryptosporidiosis (CRYPTOFAZ): study protocol for a randomized controlled trial." 01/01/2022 - "After establishing exposure-response relationships for clofazimine treatment of Cryptosporidium infection in our preclinical model studies, it was unmistakable that the clofazimine levels observed in the phase 2a study participants were well below concentrations associated with anti-Cryptosporidium efficacy. "

Related Drugs and Biologics

1.	Rifampin (Rifampicin)
2.	Dapsone
3.	Ethambutol (Myambutol)
4.	Clarithromycin (Biaxin)
5.	Rifabutin (Ansamycin)
6.	Anti-Bacterial Agents (Antibiotics)
7.	bedaquiline (R207910)
8.	Clofazimine (Lamprene)
9.	Amikacin (A.M.K)
10.	Isoniazid (Ftivazide)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Laparotomy
5.	Gluten-Free Diet