Clathrin

The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.

Networked: 704 relevant articles (11 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Awasthi, Sanjay: 6 articles (10/2021 - 03/2010)
2.	Singhal, Sharad S: 6 articles (10/2021 - 03/2010)
3.	Zhou, Bin: 6 articles (01/2021 - 10/2016)
4.	Haucke, Volker: 6 articles (01/2019 - 08/2011)
5.	Singhal, Jyotsana: 5 articles (01/2021 - 03/2010)
6.	Brodsky, Frances M: 5 articles (01/2020 - 10/2011)
7.	Watanabe, Toshio: 5 articles (01/2020 - 01/2012)
8.	Damonte, Elsa B: 5 articles (01/2018 - 02/2008)
9.	Royle, Stephen J: 5 articles (08/2015 - 04/2005)
10.	Yao, Pamela J: 5 articles (09/2010 - 01/2004)

Related Diseases

1.	Neoplasms (Cancer) 10/19/2016 - "UA-PSiNPs with significantly improved stability in physiological conditions were internalized into tumor cells by macropinocytosis-, caveolae-, and clathrin-mediated endocytosis and mainly colocalized with Golgi apparatus and lysosomes. " 09/30/2020 - "Our study demonstrated for the first time the ability of RrA to penetrate into human cancer cells and the involvement of clathrin receptors in this process." 05/01/2011 - "However, several recent studies identified that the TACC3 complex at microtubules contains clathrin in addition to its previously identified binding partner, colonic and hepatic tumor overexpressed gene (ch-TOG). " 08/18/2023 - "Among these are flat clathrin lattices (FCLs), alternative clathrin structures that have been found in specific cell types, including cancer cells. " 03/25/2023 - "PCA/miR-34a nanoparticles can be uptake into tumor cells through clathrin and caveolae-mediated endocytosis, and directly regulate the expression of oncogenes, thus promoting tumor cell apoptosis and relieving bone tissue erosion. "
2.	Infections 04/01/2015 - "This study provides relevant evidence that sheds light on the regulatory mechanisms of JEV infection in host cells, especially on the process of clathrin-mediated endocytosis. " 01/01/2012 - "Besides the demonstration of a different intracellular trafficking for two DENV-2 strains that shared the initial clathrin-independent internalization route, these studies proved for the first time the involvement of the slow recycling pathway for DENV-2 productive infection." 03/01/2004 - "For this study, we observed the effects of drugs and of dominant-negative mutants, known to impair clathrin-mediated endocytosis and endocytosis mediated by caveolae, on rotavirus cell infection. " 02/01/2023 - "Additionally, ArF-BAR is involved in clathrin-mediated mechanism of endocytosis which is required for host infection and disease development. " 01/01/2023 - "Immunopurification of clathrin- and NbAra6-associated vesicles during infection showed that RXLR effectors Pi04314-RFP and AvrBlb1-RFP, but not apoplastic effector PiSCR74-RFP, were co-immunoprecipitated during infection with pathogen strains secreting these effectors. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "Prior to the animal model experiments, the main internalization pathways for the nanovectors in MDA-MB435 breast cancer cells were determined to be based on caveolae- and clathrin-mediated endocytosis. " 10/01/2008 - "Further characterization of this novel clathrin-, caveolae- and Rho-family-independent endocytic pathway might reveal new strategies for the downregulation of ErbB2 in breast cancer." 09/01/2021 - "Further, an improved transfection efficiency in MDA-MB-231 and 4T1 breast cancer cells was observed with uptake primarily through lipid-raft and clathrin-mediated endocytosis. " 03/30/2018 - "In vitro biological studies on breast cancer cell lines (MCF-7 and T47D cells) revealed that F-P-M-ZnO@Fe2O3 nanoparticles can be internalized by clathrin-mediated endocytosis in energy-dependent and folate receptor-dependent manner. " 11/21/2020 - "Finally, we demonstrate the clathrin-mediated endocytic pathway of the native FL-M6PGP polymer and RBOE loaded M6PGP micellar-nanocarriers, and selective trafficking of MCF-7 and MDA-MB-231 breast cancer cell lysosomes, demonstrating their potential applicability toward receptor-mediated lysosomal cargo delivery."
4.	Starvation 01/01/2022 - "Immunolocalization, membrane fractionation, and pharmacological inhibition studies showed increased clathrin-mediated CLDN2 endocytosis upon starvation. " 01/01/1997 - "When exposed to starvation conditions, clathrin-minus cells streamed and aggregated more slowly than wild-type cells. " 07/28/2022 - "Glutamine starvation in HeLa cells was found to induce cellular uptake of S2 via clathrin-mediated endocytosis, thus facilitating the improved antitumor effects of the combined treatment. " 01/01/2022 - "The co-immunoprecipitation studies showed increased association of CLDN2 with clathrin and adaptor protein AP2 (AP2A1 and AP2M1 subunits) as well as LC3 and lysosomes upon starvation, signifying the role of clathrin-mediated endocytosis in autophagy-induced CLDN2 degradation. " 01/01/2021 - "The results reveal that starvation hampers clathrin-mediated endocytosis, resulting in MT1-MMP accumulation in arrested clathrin-coated pits. "
5.	Colorectal Neoplasms (Colorectal Cancer) 08/18/2023 - "Flat clathrin lattices are linked to metastatic potential in colorectal cancer." 12/15/2019 - "These exosomes displayed enhanced cellular uptake via both clathrin-dependent and -independent endocytosis pathways, and significantly improved cytotoxicity of aspirin to breast and colorectal cancer cells, accompanied by the enhanced apoptosis and autophagy. " 04/01/2021 - "MACC1 regulates clathrin-mediated endocytosis and receptor recycling of transferrin receptor and EGFR in colorectal cancer." 10/15/2014 - "Indeed, this immunotoxin specifically killed GUCY2C-expressing colorectal cancer cells in a lysosomal- and clathrin-dependent fashion. " 01/01/2022 - "In this work, we deciphered that Camptothesome was taken up by colorectal cancer (CRC) cells through primarily the clathrin-mediated endocytotic pathway and displayed the potential of eliciting robust immunogenic cancer cell death (ICD) via upregulating calreticulin, high mobility group box 1 protein (HMGB-1), and adenosine triphosphate (ATP), three hallmarks involved in the induction of ICD. "

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Ligands
3.	Lipids
4.	Caveolins
5.	Glutamic Acid (Glutamate)
6.	Clathrin Heavy Chains
7.	Dynamin II
8.	Adenosine Triphosphate (ATP)
9.	Matrix Metalloproteinases (MMPs)
10.	erucylphosphocholine

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Lasers (Laser)
4.	Enzyme Replacement Therapy
5.	Nanospheres