Clathrin

The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. Each molecule of clathrin consists of three light chains (CLATHRIN LIGHT CHAINS) and three heavy chains (CLATHRIN HEAVY CHAINS) that form a structure called a triskelion. Clathrin also interacts with cytoskeletal proteins.

Networked: 408 relevant articles (3 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yao, Pamela J: 5 articles (09/2010 - 01/2004)
2.	Haucke, Volker: 4 articles (02/2015 - 08/2011)
3.	Castilla, Viviana: 4 articles (01/2015 - 02/2008)
4.	Damonte, Elsa B: 4 articles (01/2015 - 02/2008)
5.	Bohlander, S K: 4 articles (11/2011 - 01/2000)
6.	Kirchhausen, Tomas: 4 articles (03/2011 - 11/2007)
7.	Jackson, Terry: 4 articles (06/2010 - 07/2005)
8.	Monaghan, Paul: 4 articles (06/2010 - 07/2005)
9.	Awasthi, Sanjay: 3 articles (10/2015 - 03/2010)
10.	Singhal, Jyotsana: 3 articles (10/2015 - 03/2010)

Related Diseases

1.	Infection 04/01/2015 - "This study provides relevant evidence that sheds light on the regulatory mechanisms of JEV infection in host cells, especially on the process of clathrin-mediated endocytosis. " 05/01/2014 - "A previous microarray study demonstrated that clathrin coat assembly protein 17 (AP17) was significantly up-regulated after YHV infection (Pongsomboon et al., 2011). " 01/01/2012 - "Besides the demonstration of a different intracellular trafficking for two DENV-2 strains that shared the initial clathrin-independent internalization route, these studies proved for the first time the involvement of the slow recycling pathway for DENV-2 productive infection." 01/01/2008 - "Using immunofluorescence and infection studies we show in contrast to published data that infectious entry of HPV16 occurs in a clathrin- and caveolin-independent manner. " 03/01/2004 - "For this study, we observed the effects of drugs and of dominant-negative mutants, known to impair clathrin-mediated endocytosis and endocytosis mediated by caveolae, on rotavirus cell infection. "
2.	Neoplasms (Cancer) 10/01/2015 - "Low-Intensity Ultrasound Promotes Clathrin-Dependent Endocytosis for Drug Penetration into Tumor Cells." 09/14/2015 - "Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis." 07/10/2015 - "SVS-1 is stable in serum and small molecules attached to the peptide are effectively delivered to cancer cells via mechanisms involving physical translocation and, to a lesser extent, clathrin-dependent endocytosis. " 06/01/2015 - "The most enriched canonical pathways were clathrin-mediated endocytosis signaling, molecular mechanisms of cancer and integrin signaling. " 08/01/2014 - "Equipped with a PEG shell, the nanocarriers displayed good stability and can be internalized by a variety of cancer cell lines via the lipid raft and clathrin-mediated endocytotic pathway without premature leakage, which showed a high synergetic activity of CPT and Dox toward various cancer cells. "
3.	Emphysema 09/01/2009 - "Our results suggest that clathrin-mediated endocytosis regulates A1AT intracellular function in the lung endothelium and may be an important determinant of the serpin's protection against developing cigarette smoke-induced emphysema."
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2012 - "This combined data model identified the MAPK/ERK pathway and clathrin-mediated receptor endocytosis as key pathways in Alzheimer's disease. " 07/01/2009 - "Clathrin-mediated endocytosis and Alzheimer's disease: an update." 01/01/2004 - "Synaptic frailty and clathrin-mediated synaptic vesicle trafficking in Alzheimer's disease." 11/01/2000 - "Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease." 10/10/1994 - "Clathrin, which constitutes coated vesicles and plays important roles in neuronal functions, has been reported to be involved in the pathology of Alzheimer's disease. "
5.	Myeloid Leukemia (Leukemia, Myelocytic) 01/01/2014 - "Both AP180 and its ubiquitously expressed homolog clathrin assembly lymphoid myeloid leukemia protein (CALM) control vesicle size and shape in clathrin mediated endocytosis. " 01/01/2014 - "Both clathrin assembly and cargo sorting functions are features of the two gene family consisting of assembly protein 180 kDa (AP180) and clathrin assembly lymphoid myeloid leukemia protein (CALM). " 11/01/2011 - "The t(10;11)(p13;q14) translocation results in the fusion of the CALM (clathrin assembly lymphoid myeloid leukemia protein) and AF10 genes. " 04/01/2010 - "The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with the AF10 gene; these genes are present on chromosomes 11 and 10, respectively. " 03/01/2008 - "Clathrin assembly lymphoid myeloid leukemia protein (CALM) is a clathrin assembly protein with a domain structure similar to the neuron-specific assembly protein AP180. "

Related Drugs and Biologics

1.	Clathrin Heavy Chains
2.	Smoke
3.	Glutathione (Reduced Glutathione)
4.	Proteins (Proteins, Gene)
5.	Cholesterol
6.	Phosphatidylinositols (Phosphatidylinositol)
7.	Transferrin (beta 2 Transferrin)
8.	Carbon Monoxide
9.	Clathrin Light Chains
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Nanospheres
3.	Orthopedic Procedures
4.	Heterologous Transplantation (Xenotransplantation)
5.	Therapeutics