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Cimetidine (Biomet)

A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRINS output. It also blocks the activity of CYTOCHROME P-450 which might explain proposals for use in NEOADJUVANT THERAPY.

Also Known As:

Biomet; Tagamet; Altramet; Biomet400; Cimetidine HCl; Cimetidine Hydrochloride; Eureceptor; Histodil; N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine; SK&F-92334; SKF-92334; HCl, Cimetidine; Hydrochloride, Cimetidine; SK&F 92334; SK&F92334; SKF 92334; SKF92334; Guanidine, N-cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-

Networked: 3557 relevant articles (361 outcomes, 646 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sasso-Cerri, Estela: 7 articles (11/2015 - 01/2008)
2.	Kobayashi, Kenichi: 6 articles (12/2009 - 09/2003)
3.	Lemos, Marivane: 5 articles (11/2011 - 07/2007)
4.	Cerri, Paulo S: 4 articles (11/2015 - 01/2008)
5.	Imaeda, Yoshihiro: 4 articles (12/2009 - 10/2003)
6.	Matsumoto, Sumio: 4 articles (12/2009 - 10/2003)
7.	Beltrame, Flávia L: 3 articles (11/2015 - 01/2011)
8.	Cotton, Robert B: 3 articles (06/2013 - 01/2006)
9.	Okuda, Masahiro: 3 articles (01/2013 - 10/2004)
10.	Niero, Rivaldo: 3 articles (11/2011 - 09/2007)

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer) 10/01/1982 - "Cimetidine therapy has proved to be effective in healing most duodenal ulcers and in reducing the frequency of reulceration. " 10/01/1980 - "We studied the healing efficacy of cimetidine or placebo in 23 endoscopically proven duodenal ulcer outpatients in a randomized, controlled, prospective, double-blind trial. " 12/01/1990 - "A randomized controlled trial was carried out to compare the efficacy of conventional 400 mg twice daily dose of cimetidine with single bedtime 800 mg dose, in 40 patients with endoscopically proven duodenal ulcer. " 01/01/1982 - "An intensive antacid regimen, 15 to 30 ml 1 and 3 hours after each meal and at bedtime, has a significant effect on duodenal ulcer healing as compared to placebo and is as effective as cimetidine in endoscopically assessed trials. " 04/01/1978 - "Clinical trials have shown cimetidine to be effective in healing duodenal ulcers and free of significant side effects with short-term usage. "
2.	Ulcer 01/01/1978 - "In most studies Cimetidine is superior to placebo or equipotent to a high dose antacid regimen, the latter being accepted to be of beneficial effect on ulcer healing. " 07/01/1991 - "Cimetidine provided the best protection against stress-induced ulcers. " 01/01/1978 - "3. The marked sustained reduction of acid production most probably accounts for the protective effects of cimetidine against ulcer production in the rat stomach." 09/01/1978 - "Cimetidine, therefore, seems to be very effective in preventing stress induced ulcers in rat when instilled in the stomach before the stress." 01/01/1988 - "The decrease in the size of the ulcer was significantly greater in the first two weeks of cimetidine treatment than in the cimetidine-placebo group (P less than 0.05). "
3.	Stomach Ulcer (Gastric Ulcer) 01/01/1980 - "We studied the healing efficacy of cimetidine or placebo on 24 endoscopically proven prepyloric gastric ulcer outpatients in randomized controlled prospective double blind trial. " 03/01/2011 - "NS and NH are equally effective in healing of gastric ulcer similar to cimetidine. " 01/01/1984 - "It is concluded with caution that cimetidine might be effective in haemorrhage from gastric ulcer in patients 60 years and older. " 01/01/1988 - "The efficacy of a 4-week cimetidine treatment was examined by a double-blind randomized study in 37 outpatients with endoscopically verified chronic gastric ulcer. " 10/01/1983 - "The efficacy of Cimetidine in gastric ulcer, however requires further study."
4.	Hemorrhage 08/01/1993 - "Acid suppression with cimetidine may be effective in selected patients with recurrent HG, but effective therapy for most patients with this form of GI bleeding is still uncertain. " 10/08/1978 - "As for the treatment of hemorrhage, it should first be medical and cimetidine gives at present the best results. " 03/01/1981 - "Cimetidine or antacid prophylaxis significantly decreased the incidence of upper gastrointestinal bleeding in the high risk patients." 01/01/1985 - "These results do not suggest that cimetidine was effective in preventing stress-induced upper gastrointestinal bleeding." 08/01/1985 - "The efficacy of cimetidine in the prevention and treatment of stress-induced gastroduodenal lesions was evaluated in a randomized, double-blind, placebo-controlled study in which serial endoscopy was used to examine patients without clinical evidence of bleeding who were admitted to a medical intensive care unit. "
5.	Peptic Ulcer (Peptic Ulcers) 04/01/1994 - "We conclude that twice-daily cimetidine at a dosage of 20 mg/kg/day is as effective for the symptomatic improvement and healing of peptic ulcer as the conventional three- or four-times-daily regimens. " 10/01/1988 - "It is concluded that long-term use of cimetidine is effective in the management of peptic ulcer disease, and continuous treatment for up to 6 years has not revealed any previously unknown hazard." 06/01/1986 - "Both are endocrinopathies that require doses of cimetidine in excess of that normally considered therapeutic for peptic ulcer disease. " 02/01/1978 - "Cimetidine: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease." 10/01/1983 - "An open study was conducted to assess the efficacy of Cimetidine one gram daily in the treatment of peptic ulcer amongst outpatients in Singapore. "

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4.	Pirenzepine
5.	Omeprazole (Esomeprazole)
6.	Famotidine (Pepcid)
7.	Antacids
8.	Misoprostol (Cytotec)
9.	Diphenhydramine (Benadryl)
10.	bismuth tripotassium dicitrate (bismuth subcitrate)

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1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
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4.	Prostheses and Implants (Prosthesis)
5.	Cesarean Section (Caesarean Section)