Ciguatoxins

Polycyclic ethers produced by Gambierdiscus (DINOFLAGELLATES) from gambiertoxins, which are ingested by fish which in turn may be ingested by humans who are susceptible to the CIGUATERA POISONING.

Also Known As:

Networked: 161 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hirama, Masahiro: 20 articles (06/2015 - 12/2002)
2.	Lewis, Richard J: 10 articles (12/2013 - 06/2002)
3.	Inoue, Masayuki: 9 articles (02/2015 - 12/2002)
4.	Chinain, Mireille: 9 articles (06/2014 - 09/2005)
5.	Yamashita, Shuji: 8 articles (06/2015 - 07/2006)
6.	Laurent, Dominique: 8 articles (01/2013 - 01/2005)
7.	Ramsdell, John S: 7 articles (03/2013 - 09/2005)
8.	Botana, Luis M: 6 articles (09/2015 - 01/2006)
9.	Molgó, Jordi: 6 articles (10/2014 - 12/2002)
10.	Tsumuraya, Takeshi: 6 articles (03/2014 - 06/2003)

Related Diseases

1.	Hyperalgesia 10/01/2013 - "However, differences in the efficacy of these compounds to reverse ciguatoxin-induced cold allodynia did not correlate with their potency to inhibit ciguatoxin-induced responses in SH-SY5Y cells or at heterologously expressed Nav1.3, Nav1.6, Nav1.7, or Nav1.8, indicating cold allodynia might be more complex than simple activation of Nav channels. " 10/03/2012 - "Functional MRI studies revealed that ciguatoxin-induced cold allodynia enhanced the BOLD (Blood Oxygenation Level Dependent) signal, an effect that was blunted in TRPA1-deficient mice, confirming an important role for TRPA1 in the pathogenesis of cold allodynia." 10/01/2013 - "To establish their in vivo efficacy, we used a novel animal model of ciguatoxin-induced cold allodynia. " 10/01/2013 - "We show that intracutaneous administration of ciguatoxin in humans elicits a pronounced axon-reflex flare and replicates cold allodynia. " 10/01/2013 - "Analgesic treatment of ciguatoxin-induced cold allodynia."
2.	Ciguatera Poisoning (Ciguatera) 10/01/2007 - "In order to assess the ciguatera risk in two islands of French Polynesia, Tubuai (Australes) and Nuku Hiva (Marquesas), a study was carried out on both Gambierdiscus populations as well as on various fish species using the receptor-binding assay (RBA) to detect and quantify ciguatoxins. " 12/15/2015 - "Ciguatera fish poisoning is a debilitating human neuro-intoxication caused by consumption of tropical marine organisms, contaminated with bioaccumulated ciguatoxins (CTXs). " 11/04/2015 - "To determine the ciguatoxic potential of brown-marbled grouper (Epinephelus fuscoguttatus) in relation to fish size and geographical origin, this review systematically analyzed: 1) reports of large ciguatera outbreaks and outbreaks with description of the fish size; 2) Pacific ciguatoxin (P-CTX) profiles and levels and mouse bioassay results in fish samples from ciguatera incidents; 3) P-CTX profiles and levels and risk of toxicity in relation to fish size and origin; 4) regulatory measures restricting fish trade and fish size preference of the consumers. " 11/01/2015 - "Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies)." 09/01/2015 - "Ciguatera fish poisoning (CFP) is a syndrome caused by the ingestion of fish contaminated with Ciguatoxins (CTXs). "
3.	Body Weight (Weight, Body) 03/15/2013 - "In this study, we determined the toxicokinetic parameters of the Pacific ciguatoxin P-CTX-1 in rats after an intravenous (iv) dose of 0.13 ng P-CTX-1 per g of body weight. " 06/18/2011 - "In this study we evaluate the toxicokinetics of one of the most common ciguatoxins found in the Pacific, the P-CTX-1, in rat after an oral or intraperitoneal (ip) dose of 0.26 μg/kg body weight. "
4.	Poisoning 01/01/1991 - "Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning." 12/01/2013 - "NPDS reported an average of 173 exposure calls for ciguatoxin and 200 exposure calls for scombroid fish poisoning annually (2005-2009). " 10/01/2011 - "Fatality and long-term sequelae are not uncommon with ciguatoxin poisoning and educating the general population is essential." 05/15/2009 - "Ladder-shaped polyether (LSP) compounds represented by brevetoxins and ciguatoxins were largely discovered in association with seafood poisoning. " 11/01/2007 - "Ciguatoxin may be a terrible coral fish toxin that can result in poisoning in people who eat fish containing ciguatoxin. "
5.	Neuroblastoma 10/01/2013 - "To identify compounds able to inhibit ciguatoxin-induced Nav responses, we developed a novel in vitro ciguatoxin assay using the human neuroblastoma cell line SH-SY5Y. " 08/30/2012 - "foertherianum leaves was prepared and studied for its effects against a Pacific ciguatoxin (P-CTX-1B) in the neuroblastoma cell assay and the receptor binding assay. " 01/01/2012 - "Towards the standardisation of the neuroblastoma (neuro-2a) cell-based assay for ciguatoxin-like toxicity detection in fish: application to fish caught in the Canary Islands." 01/01/2008 - "Detection of ciguatoxin in fish tissue using sandwich ELISA and neuroblastoma cell bioassay." 09/01/2005 - "Quantitation by the neuroblastoma cytotoxicity assay of Caribbean ciguatoxin (C-CTX-1) spiked into mice blood was made with good precision and recovery. "

Related Drugs and Biologics

1.	Okadaic Acid
2.	Tetrodotoxin (Tetradotoxin)
3.	gambierol
4.	maitotoxin
5.	Acids
6.	Sodium Channels (Sodium Channel)
7.	Neurotoxins
8.	Ethers
9.	Veratridine
10.	Ciguatoxins