Ciguatoxins

Polycyclic ethers produced by Gambierdiscus (DINOFLAGELLATES) from gambiertoxins, which are ingested by fish which in turn may be ingested by humans who are susceptible to the CIGUATERA POISONING.

Also Known As:

Networked: 292 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chinain, Mireille: 27 articles (05/2022 - 09/2005)
2.	Hirama, Masahiro: 22 articles (01/2019 - 12/2002)
3.	Lewis, Richard J: 19 articles (07/2021 - 06/2002)
4.	Darius, Hélène Taiana: 16 articles (05/2022 - 01/2013)
5.	Hess, Philipp: 14 articles (05/2022 - 01/2017)
6.	Viallon, Jérôme: 11 articles (05/2022 - 07/2016)
7.	Botana, Luis M: 10 articles (02/2022 - 01/2006)
8.	Litaker, R Wayne: 9 articles (05/2022 - 01/2016)
9.	Diogène, Jorge: 9 articles (03/2022 - 06/2010)
10.	Tsumuraya, Takeshi: 9 articles (10/2020 - 06/2003)

Related Diseases

1.	Hyperalgesia 10/01/2013 - "However, differences in the efficacy of these compounds to reverse ciguatoxin-induced cold allodynia did not correlate with their potency to inhibit ciguatoxin-induced responses in SH-SY5Y cells or at heterologously expressed Nav1.3, Nav1.6, Nav1.7, or Nav1.8, indicating cold allodynia might be more complex than simple activation of Nav channels. " 10/03/2012 - "Functional MRI studies revealed that ciguatoxin-induced cold allodynia enhanced the BOLD (Blood Oxygenation Level Dependent) signal, an effect that was blunted in TRPA1-deficient mice, confirming an important role for TRPA1 in the pathogenesis of cold allodynia." 01/01/2017 - "Brain mechanisms of abnormal temperature perception in cold allodynia induced by ciguatoxin." 10/01/2013 - "To establish their in vivo efficacy, we used a novel animal model of ciguatoxin-induced cold allodynia. " 10/01/2013 - "We show that intracutaneous administration of ciguatoxin in humans elicits a pronounced axon-reflex flare and replicates cold allodynia. "
2.	Ciguatera Poisoning (Ciguatera) 01/01/2019 - "These novel findings augment the knowledge of the ciguatoxin-source dinoflagellates that are present in Cuba, however further studies are needed to better understand the correlation between their abundance, species-specific toxin production in the environment, and the risk for fish contamination, in order to develop better informed ciguatera risk management strategies." 01/01/2019 - "Thus, further studies should be pursued to clarify the similarities and differences in the biological activity between the known ciguatoxins and the new identified molecule as well as its contribution to the neurological symptoms of ciguatera." 10/01/2007 - "In order to assess the ciguatera risk in two islands of French Polynesia, Tubuai (Australes) and Nuku Hiva (Marquesas), a study was carried out on both Gambierdiscus populations as well as on various fish species using the receptor-binding assay (RBA) to detect and quantify ciguatoxins. " 01/01/1993 - "This study presents data on the evaluation of a laboratory ciguatera kit based on the solid phase immunobead assay (SPIA) for the detection of ciguatoxin in Hawaiian reef fish. " 12/01/2023 - "Ciguatera poisoning (CP) is endemic to several subtropical and tropical regions and is caused by the consumption of fish contaminated with ciguatoxins (CTXs). "
3.	Neuroblastoma 11/13/2023 - "Mouse N2a Neuroblastoma Assay: Uncertainties and Comparison with Alternative Cell-Based Assays for Ciguatoxin Detection." 07/01/2023 - "Functional assays for detecting ciguatoxins in fish include receptor binding (RBA) and neuroblastoma cell-based assay (N2a assay), which can detect all CTX congeners. " 07/01/2023 - "Evaluation of relative potency of calibrated ciguatoxin congeners by near-infrared fluorescent receptor binding and neuroblastoma cell-based assays." 10/01/2022 - "In the lipophilic fractions, the neuroblastoma cell-based assay (CBA-N2a) showed no ciguatoxin (CTX)-like activity for nine of the 10 isolates, and an atypical pattern for CAWD233 isolate which showed cytotoxic activity in OV- and OV+ conditions. " 01/01/2020 - "The use of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) combined with neuroblastoma cell assay (N2a) allowed the initial confirmation of the presence of C-CTX1 in contaminated fish samples from the abovementioned areas, nevertheless the lack of commercially available reference materials for these particular ciguatoxin (CTX) analogues has been a major limitation to progress research. "
4.	Body Weight (Weight, Body) 03/15/2013 - "In this study, we determined the toxicokinetic parameters of the Pacific ciguatoxin P-CTX-1 in rats after an intravenous (iv) dose of 0.13 ng P-CTX-1 per g of body weight. " 06/18/2011 - "In this study we evaluate the toxicokinetics of one of the most common ciguatoxins found in the Pacific, the P-CTX-1, in rat after an oral or intraperitoneal (ip) dose of 0.26 μg/kg body weight. "
5.	Poisoning 01/01/1991 - "Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning." 01/01/2022 - "Ciguatoxins and maitotoxins, the two major toxins produced by Gambierdiscus, act on voltage-gated channels and TRPA1 receptors, consequently leading to poisoning and even death in both humans and animals. " 12/07/2018 - "Ciguatoxins (CTXs), endemic from tropical and subtropical regions of the Pacific and Indian Ocean and the Caribbean Sea, have caused several human poisonings during the last decade in Europe. " 12/01/2013 - "NPDS reported an average of 173 exposure calls for ciguatoxin and 200 exposure calls for scombroid fish poisoning annually (2005-2009). " 10/01/2011 - "Fatality and long-term sequelae are not uncommon with ciguatoxin poisoning and educating the general population is essential."

Related Drugs and Biologics

1.	Tetrodotoxin (Tetradotoxin)
2.	Okadaic Acid
3.	gambierol
4.	maitotoxin
5.	Acids
6.	Neurotoxins
7.	Sodium Channels (Sodium Channel)
8.	Polyether Toxins
9.	Voltage-Gated Sodium Channels
10.	Marine Toxins

Related Therapies and Procedures

1.	Therapeutics