Chromomycins

A complex of several closely related glycosidic antibiotics from Streptomyces griseus. The major component, CHROMOMYCIN A3, is used as a fluorescent stain of DNA where it attaches and inhibits RNA synthesis. It is also used as an antineoplastic agent, especially for solid tumors.

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Networked: 19 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ménézo, Yves: 1 article (01/2021)
2.	Afiyatulov, Shamil Sh: 1 article (04/2017)
3.	Dmitrenok, Pavel S: 1 article (04/2017)
4.	Ermakova, Svetlana P: 1 article (04/2017)
5.	Kalinovskaya, Nataliya L: 1 article (04/2017)
6.	Kalinovsky, Anatoly I: 1 article (04/2017)
7.	Romanenko, Lyudmila A: 1 article (04/2017)
8.	Espindola, Ana Paula D M: 1 article (09/2011)
9.	Hu, Youcai: 1 article (09/2011)
10.	MacMillan, John B: 1 article (09/2011)

Related Diseases

1.	Delayed Hypersensitivity (Hypersensitivity, Type IV) 01/01/2008 - "Chromomycin was effective in detecting delayed hypersensitivity in patients with chromoblastomycosis caused by F. " 01/01/2008 - "An experimental study was conducted between January 2002 and April 2003 for the detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin) in skin tests. " 01/01/2008 - "Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin)."
2.	Chromoblastomycosis (Chromomycosis) 01/01/2008 - "A cellular immune response to chromomycin was detected in 18 (90.0%) of the 20 patients with chromoblastomycosis caused by F. " 01/01/2008 - "Chromomycin was effective in detecting delayed hypersensitivity in patients with chromoblastomycosis caused by F. " 07/01/1969 - "[Experiences with metalic antigen and chromomycin for the diagnosis of chromoblastomycosis]."
3.	Neoplasms (Cancer) 04/01/2017 - "This is the first study reporting the inhibitory effects of chromomycin analogs 1-5 on the colony formation of the investigated cancer cell lines. " 11/01/2006 - "Mithramycin and chromomycins are the most representative members of the family, mithramycin being used as a chemotherapeutic agent for the treatment of several cancer diseases. " 03/01/1996 - "Mithramycin, chromomycin, and olivomycin belong to the aureolic acid family of clinically important anti-tumor agents. " 08/01/1977 - "Combination chemotherapy for solid tumors using 5-fluorouracil, chromomycin-A, and prednisolone." 01/01/1976 - "Transfer RNA nucleotidyl transferase from Ehrlich tumor cells was inhibited by proflavine sulfate and ethidium bromide but not by actinomycin D, chromomycin, rifamycin SV, rifampin, daunomycin, or alpha-amanitin. "
4.	Carcinoma (Carcinomatosis) 03/01/1985 - "High-quality bivariate Hoechst vs. chromomycin fluorescence distributions were obtained for chromosomes isolated from a human fibroblast cell strain, a human colon carcinoma cell line, and human peripheral blood lymphocyte cultures. " 06/01/1962 - "[The cytological and karyological effects of chromomycin (CM) upon the human carcinoma cells]." 03/01/1975 - "Experimental results showed that among the five A-A derivatives possessing considerable activity against Ehlich carcinoma, A-144 and A-145 were found to be more effective than chromomycin A and showed activity similar to that of cyclophosphamide against ascites Sarcoma 180. "
5.	Triploidy 09/28/2010 - "Treatment with fluorochrome chromomycin A(3) revealed fluorescent bands coincident with those of the silver-stained nucleolar organizer region, in both diploid and triploid individuals, showing that this is a GC-rich region. "

Related Drugs and Biologics

1.	Antigens
2.	Plicamycin
3.	Olivomycins
4.	Dactinomycin (Actinomycin)
5.	Alpha-Amanitin
6.	Transferases
7.	Sulfates (Sulfates, Inorganic)
8.	Solvents
9.	Silver
10.	Transfer RNA (tRNA)

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)