Choristoma (Ectopic Tissue)

A mass of histologically normal tissue present in an abnormal location.

Also Known As:

Ectopic Tissue; Aberrant Tissues; Choristomas; Ectopic Tissues; Heterotopic Tissues; Tissue, Aberrant; Tissue, Ectopic; Tissue, Heterotopic; Tissues, Aberrant; Tissues, Ectopic; Tissues, Heterotopic; Aberrant Tissue; Heterotopic Tissue

Networked: 294 relevant articles (4 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Anatomical Pathological Conditions
  - Choristoma: 294
    - Bilateral Choroidal Osteoma: 6
    - Dermoids of cornea

Related Diseases

1.	Neoplasms (Cancer)
2.	Congenital Cholesteatoma
3.	Prostatism
4.	Microphthalmos
5.	Endometriosis

Experts

1.	Zhang, Wei: 3 articles (03/2020 - 09/2012)
2.	Li, Da-Jin: 3 articles (10/2016 - 04/2006)
3.	Nothnick, Warren B: 2 articles (01/2022 - 01/2020)
4.	Reddy, Sekhar P: 2 articles (01/2022 - 06/2009)
5.	Korn, Bobby S: 2 articles (11/2021 - 06/2014)
6.	Aflatoonian, Reza: 2 articles (01/2021 - 07/2019)
7.	Afsharian, Parvaneh: 2 articles (01/2021 - 07/2019)
8.	Shahhoseini, Maryam: 2 articles (01/2021 - 07/2019)
9.	Liu, Tao: 2 articles (12/2020 - 03/2020)
10.	Carter, Jodi M: 2 articles (01/2019 - 10/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Choristoma:

1.	Telomerase (Telomerase Reverse Transcriptase)IBA 05/01/2001 - "In addition, the finding that telomerase activity was weak in the congenital cholesteatoma tissue suggests the possibility that vestigial fetal tissues and aberrant tissues are naturally eliminated in normal subjects as a result of apoptosis."
2.	CollagenIBA 01/01/2022 - "Organ fibrosis is characterized by epithelial injury and aberrant tissue repair, where activated effector cells, mostly fibroblasts and myofibroblasts, excessively deposit collagen into the extracellular matrix. " 01/01/2016 - "ER stress and apoptosis of type II pneumocytes lead to aberrant tissue repair and progressive collagen deposition in pulmonary fibrosis. " 02/01/2004 - "There was no collagen deposition/fibrosis or aberrant tissue. " 01/01/2022 - "In mice with fibrotic lung injury, treatment with the coated MSCs maintained normal collagen levels, fibre density and microelasticity in lung tissue, and the continuous presentation of recombinant TNF-α in the gel facilitated the reversal of aberrant tissue remodelling by the cells when inflammation subsided in the host. " 01/01/2017 - "Ectopic tissue engineered ligament with silk collagen scaffold for ACL regeneration: A preliminary study."
3.	Matrix Metalloproteinases (MMPs)IBA 01/01/2015 - "Thus, aberrant tissue degradation is associated to matrix metalloproteinases (MMPs) overexpression resulting from different mechanisms including epigenetic events. " 10/01/2002 - "Our studies indicate that either eutopic or ectopic tissue from women with endometriosis exhibit patterns of altered MMP regulation in vivo. " 12/01/2020 - "Aberrant tissue expression of matrix metalloproteinases has been observed in acne. " 09/01/2016 - "An imbalance between MMPs and TIMPs has been linked with acute and chronic inflammation and aberrant tissue remodeling, as seen in IBD. " 10/01/2018 - "Dysregulation of MMPs is observed in patholofgical conditions, including atherosclerosis, which is associated with hyperactivation of MMPs, aberrant tissue remodeling and neovascularization of the growing atherosclerotic plaques. "
4.	Progesterone FDA LinkGeneric 01/01/1993 - "All of these data could provide an explanation for the low circulating level of progesterone, which may directly or indirectly affect the spontaneous expulsion of this aberrant tissue in the second trimester of pregnancy." 06/01/1990 - "The present findings could provide an explanation for the low level of progesterone in patients with CHM in the second trimester of pregnancy which in turn may directly or indirectly affect the spontaneous expulsion of this aberrant tissue." 04/01/2014 - "Since eutopic and ectopic tissues do not respond sufficiently to progesterone in women with endometriosis, further study is necessary to evaluate the effect of epigenetic alterations in progesterone-resistance in this enigmatic disease." 01/01/2022 - "An inability of the eutopic endometrium to properly respond to progesterone is believed to contribute to the infertility associated with the disease, while an altered responsiveness of endometriotic lesion tissue may contribute to the survival of the ectopic tissue and associated symptoms. " 02/01/2013 - "In endometriosis, eutopic and ectopic tissues do not respond sufficiently to progesterone and are considered to be progesterone-resistant, which contributes to proliferation and survival. "
5.	EnzymesIBA 05/25/1999 - "The tight regulation of 1alpha-HYD in both renal and ectopic tissues has made studies of the expression and regulation of this enzyme remarkably difficult. " 03/01/2009 - "The activities of the most important steroidogenic enzymes synthesizing and inactivating 17beta-estradiol were determined by HPLC in matched eutopic and ectopic tissue from patients with endometriosis (n = 14) and in endometrium from controls (n = 20). " 08/30/2004 - "While the metalloproteinase enzymes are essential for development and remodeling of tissues, aberrant over expression of these enzymes contributes to several pathologic conditions. " 10/25/2019 - "In term of the impacts on growth factors, enzymes and enzyme inhibitors, the mechanism of acupuncture and moxibustion was explored on the analgesia for endometriosis, the inhibition of ectopic tissue angiogenesis and invasive adhesion, as well as the regulation of immune function and endocrine. "
6.	AntioxidantsIBA 11/08/2022 - "Although the pathophysiology of metabolic stress is complex, aberrant tissue damage and β-cell death are brought on by an imbalance in redox equilibrium due to insufficient levels of endogenous antioxidant expression in β-cells. " 04/01/2013 - "However, under pathological conditions, an imbalance in redox homeostasis leads to aberrant tissue damage and β-cell death due to a lack of antioxidant defense systems. " 01/01/2021 - "The current study also highlights the effects of spices on the antioxidant pathways mediated by Nrf2 (nuclear factor erythroid 2-related factor 2) and Hmox1 (heme oxygenase 1) to restore oxidative homeostasis and protect from aberrant tissue damage. " 01/01/2012 - "We studied lipid peroxidation products (thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes) in the circulation and in the tissues, antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and non-enzymatic antioxidant-reduced glutathione) of the tissues, aberrant crypt foci (ACF), and histopathological alterations. "
7.	Retinaldehyde (Retinal)IBA 04/01/1999 - "The rarely progressive nature of myelinated retinal nerve fibers and the histopathologic studies published to date suggest that myelinated retinal nerve fibers represent a striking ophthalmoscopic feature resulting from ectopic oligodendrocytes; thus, the entity may be described as an oligodendrocytic choristoma." 04/01/1999 - "To present a case demonstrating progression of retinal nerve fiber myelin and to suggest that myelinated retinal nerve fibers be considered among the peripapillary choristomas. " 08/15/1956 - "[Choristoma of retinal origin in the maxilla of an infant]." 01/01/2011 - "B-scan layer-by-layer analysis and unique SD-OCT reflectivity patterns of the following retinal white lesions are reviewed in the order of their retinal layer localization: myelinated nerve fiber layer, cotton wool spot, exudates, edema residues, drusen, fundus albipunctatus, Stargardt disease, Bietti crystalline dystrophy, punctate inner choroidopathy (PIC), presumed ocular histoplasmosis syndrome (POHS), post-photocoagulation chorioretinal scarring, and osseous choristoma. "
8.	DNA (Deoxyribonucleic Acid)IBA 07/01/1998 - "DNA-binding assays identified four Ci-Sna-binding sites in the Ci-Bra enhancer, and mutations in these sites cause otherwise normal Ci-Bra/lacZ transgenes to be misexpressed in ectopic tissues, particularly the tail muscles. " 01/01/2019 - "It is recommended that future evaluations of porcine cysticercosis in aberrant tissue locations include DNA analyses that take appropriate care to avoid the possibility of contamination of tissue specimens with DNA from a different tissue location or a different animal. " 11/01/2015 - "Our study demonstrated that DNA hypomethylation of the NF-IL6 site within the promoter of COX-2 gene could be a key mechanism for its elevated expression in the eutopic and ectopic tissues of endometriosis. "
9.	Biomarkers (Surrogate Marker)IBA 04/01/2022 - "These studies identified potential biomarkers in serum, ectopic tissue, eutopic endometrium, peritoneal fluid, follicular fluid, urine, cervical swabs and endometrial fluid. " 05/01/2020 - "The minor changes in concentration of circulating aging biomarkers in sera of PXE patients and the significant aberrant tissue specific expression seen for selected factors in PXE fibroblasts, suggests a link between ABCC6 deficiency and accelerated aging processes in affected peripheral tissues of PXE patients."
10.	Chemokine CX3CL1IBA 10/01/2016 - "We found that the eutopic endometrium had significantly higher expression of fractalkine and CX3CR1 compared to normal endometrium, and the ectopic tissues had the highest expression. " 10/01/2016 - "In this study, immunohistochemistry was performed on normal endometrium (taken from controls), eutopic endometrium (taken from patients with endometriosis), and ectopic tissues to analyze fractalkine/CX3CR1 expression. "

Therapies and Procedures

1.	Skin Transplantation (Skin Grafting) 06/01/2014 - "Surgical management of extensive epibulbar choristoma associated with microphthalmos using a simplified method of partial tumor excision and skin grafting can result in improved cosmetic outcomes."
2.	Thoracotomy 12/01/2002 - "We describe the case of a 31 year old man with a choristoma of the left diaphragmal crux where the localisation and genesis could only be cleared through lateral thoracotomy. "
3.	Lasers (Laser) 02/01/1996 - "Two patients with this complication presented with symptoms of prostatism that were relieved by laser resection of the aberrant tissue."
4.	Intravenous Administration 01/01/2019 - "To support the development of ABCB5+ MSCs for potential therapeutic topical, intramuscular and intravenous administration, we have tested our product in a series of Good Laboratory Practice-compliant nonclinical in-vivo studies addressing all relevant aspects of biosafety, including potential long-term persistence and proliferation, distribution to nontarget tissues, differentiation into undesired cell types, ectopic tissue formation, tumor formation and local tissue reaction. "
5.	Heart Transplantation (Grafting, Heart) 01/01/1999 - "Thus, the present study clearly demonstrates that aberrant tissue factor expression occurs within the coronary intima after cardiac transplantation. "