HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Choristoma (Ectopic Tissue)

A mass of histologically normal tissue present in an abnormal location.

Also Known As:

Ectopic Tissue; Aberrant Tissues; Choristomas; Ectopic Tissues; Heterotopic Tissues; Tissue, Aberrant; Tissue, Ectopic; Tissue, Heterotopic; Tissues, Aberrant; Tissues, Ectopic; Tissues, Heterotopic; Aberrant Tissue; Heterotopic Tissue

Networked: 174 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Anatomical Pathological Conditions
  - Choristoma: 174
    - Dermoids of cornea: 1

Related Diseases

1.	Neoplasms (Cancer)
2.	Prostatism
3.	Microphthalmos
4.	Cholesteatoma
5.	Endometriosis (Adenomyosis)

Experts

1.	Li, Da-Jin: 3 articles (10/2011 - 04/2006)
2.	D'Hooghe, Thomas: 2 articles (01/2014 - 03/2009)
3.	Romano, Andrea: 2 articles (01/2014 - 03/2009)
4.	Kyama, Cleophas: 2 articles (01/2014 - 03/2009)
5.	Delvoux, Bert: 2 articles (01/2014 - 03/2009)
6.	Bulun, Serdar E: 2 articles (02/2013 - 07/2002)
7.	Yu, Lei: 2 articles (12/2010 - 11/2008)
8.	Jing, Yun: 2 articles (12/2010 - 11/2008)
9.	Ma, Shan: 2 articles (12/2010 - 11/2008)
10.	Jornayvaz, François R: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Choristoma:

1.	CosmeticsIBA 01/01/2007 - "Both therapeutic and cosmetic results of surgical treatment of choristoma in children were satisfactory." 03/01/2012 - "Amniotic membrane transplantation is currently the most acceptable modality of treatment of limbal choristoma, with good cosmetic outcome." 06/01/2014 - "Surgical management of extensive epibulbar choristoma associated with microphthalmos using a simplified method of partial tumor excision and skin grafting can result in improved cosmetic outcomes."
2.	Telomerase (Telomerase Reverse Transcriptase)IBA 05/01/2001 - "In addition, the finding that telomerase activity was weak in the congenital cholesteatoma tissue suggests the possibility that vestigial fetal tissues and aberrant tissues are naturally eliminated in normal subjects as a result of apoptosis."
3.	Progesterone FDA LinkGeneric 06/01/1990 - "The present findings could provide an explanation for the low level of progesterone in patients with CHM in the second trimester of pregnancy which in turn may directly or indirectly affect the spontaneous expulsion of this aberrant tissue." 04/01/2014 - "Since eutopic and ectopic tissues do not respond sufficiently to progesterone in women with endometriosis, further study is necessary to evaluate the effect of epigenetic alterations in progesterone-resistance in this enigmatic disease." 02/01/2013 - "In endometriosis, eutopic and ectopic tissues do not respond sufficiently to progesterone and are considered to be progesterone-resistant, which contributes to proliferation and survival. " 10/01/2010 - "A local environment enriched in estrogens, progesterone resistance, local inflammatory response and multiple other molecular alterations appear to be pivotal events in the establishment and development of ectopic tissue. " 02/01/1995 - "This ectopic tissue can react to hormonal stimulation: estrogens and progesterone (growth, decidualisation, withdrawal bleeding). "
4.	Retinaldehyde (Retinal)IBA 04/01/1999 - "The rarely progressive nature of myelinated retinal nerve fibers and the histopathologic studies published to date suggest that myelinated retinal nerve fibers represent a striking ophthalmoscopic feature resulting from ectopic oligodendrocytes; thus, the entity may be described as an oligodendrocytic choristoma." 04/01/1999 - "To present a case demonstrating progression of retinal nerve fiber myelin and to suggest that myelinated retinal nerve fibers be considered among the peripapillary choristomas. " 08/15/1956 - "[Choristoma of retinal origin in the maxilla of an infant]."
5.	DNA (Deoxyribonucleic Acid)IBA 07/01/1998 - "DNA-binding assays identified four Ci-Sna-binding sites in the Ci-Bra enhancer, and mutations in these sites cause otherwise normal Ci-Bra/lacZ transgenes to be misexpressed in ectopic tissues, particularly the tail muscles. " 11/01/2015 - "Our study demonstrated that DNA hypomethylation of the NF-IL6 site within the promoter of COX-2 gene could be a key mechanism for its elevated expression in the eutopic and ectopic tissues of endometriosis. "
6.	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 04/01/2014 - "The objective of this study was to examine the expression of SLC2A genes in the endometrium of women with and without endometriosis and in the matching ectopic tissue, and to confirm the presence of the GLUT proteins in ectopic lesions. "
7.	EndostatinsIBA 01/01/2013 - "In addition to antiangiogenic effects, recent studies have revealed that endostatin may suppress aberrant tissue remodeling and scarring. "
8.	CCAAT-Enhancer-Binding Protein-betaIBA 11/01/2015 - "Our study demonstrated that DNA hypomethylation of the NF-IL6 site within the promoter of COX-2 gene could be a key mechanism for its elevated expression in the eutopic and ectopic tissues of endometriosis. "
9.	Chemokine ReceptorsIBA 04/01/2006 - "In the present study, the transcription of 18 chemokine receptors in eutopic endometrium and ectopic tissue with endometriosis was first analysed by RT-PCR. "
10.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 03/01/2000 - "This study supports the feasibility of initiating site-directed formation of bone structures at heterotopic tissue sites by means of injection of cultured periosteal cells and matrix in a fibrin glue carrier."

Therapies and Procedures

1.	Skin Transplantation (Skin Grafting) 06/01/2014 - "Surgical management of extensive epibulbar choristoma associated with microphthalmos using a simplified method of partial tumor excision and skin grafting can result in improved cosmetic outcomes."
2.	Thoracotomy 12/01/2002 - "We describe the case of a 31 year old man with a choristoma of the left diaphragmal crux where the localisation and genesis could only be cleared through lateral thoracotomy. "
3.	Lasers (Laser) 02/01/1996 - "Two patients with this complication presented with symptoms of prostatism that were relieved by laser resection of the aberrant tissue."
4.	Heart Transplantation (Grafting, Heart) 01/01/1999 - "Thus, the present study clearly demonstrates that aberrant tissue factor expression occurs within the coronary intima after cardiac transplantation. "
5.	Transplants (Transplant) 08/01/2010 - "The innate osteogenic potential of the maxillary sinus (Schneiderian) membrane: an ectopic tissue transplant model simulating sinus lifting." 10/01/2000 - "In all grafts in viable tissue, heterotopic bone was formed. " 08/01/2000 - "Finally characteristics of tissue-engineered bone graft substitutes that may contribute to development of these pathologies and device characteristics that may obviate these ectopic tissues are considered." 11/01/1998 - "Formation of this aberrant tissue should be prevented by proper positioning of the graft, by enlargement of the narrowed notch in chronic cases, by using drills of increasing diameters to avoid production of osteocartilaginous fragments, by meticulous resection of all drilling debris and ACL remnants around the tibial tunnel, and by enlarging the notch roof if any contact with the graft is present when the knee is fully extended intraoperatively." 11/01/1996 - "Large choristomas that straddle the cornea and limbus can be removed and a lamellar graft sutured to the excision site. "