Chondrocalcinosis (Pseudogout)

Presence of CALCIUM PYROPHOSPHATE in the connective tissues such as the cartilaginous structures of joints. When accompanied by GOUT-like symptoms, it is referred to as pseudogout.

Also Known As:

Networked: 664 relevant articles (22 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Gout
2.	Chondrocalcinosis (Pseudogout)
3.	Arthritis (Polyarthritis)
4.	Osteoarthritis
5.	Synovitis

Experts

1.	Rosenthal, Ann K: 8 articles (12/2021 - 03/2002)
2.	Bardin, Thomas: 8 articles (01/2020 - 12/2005)
3.	Richette, Pascal: 8 articles (01/2020 - 12/2005)
4.	Williams, Charlene J: 6 articles (12/2021 - 10/2002)
5.	Ea, Hang-Korng: 6 articles (01/2020 - 09/2005)
6.	Brown, Matthew A: 6 articles (01/2017 - 10/2002)
7.	Tedeschi, Sara K: 5 articles (05/2022 - 01/2017)
8.	Terkeltaub, Robert: 5 articles (10/2017 - 06/2002)
9.	Parperis, Konstantinos: 4 articles (06/2022 - 09/2013)
10.	Solomon, Daniel H: 4 articles (05/2022 - 06/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chondrocalcinosis:

1.	ColchicineFDA LinkGeneric 08/01/1986 - "Our study supports the effectiveness of oral colchicine as a prophylactic agent in recurring pseudogout." 08/01/2016 - "We present the case of a patient affected by generalized GA, which resolved after colchicine treatment used for concomitant crowned dens syndrome due to calcium pyrophosphate deposition disease (CPPD). " 12/15/2012 - "Colchicine 0.6 mg orally daily was initiated in March for the prophylaxis of pseudogout. " 06/01/1987 - "Prevention of acute attacks of pseudogout with oral colchicine." 08/01/1986 - "Ten patients with recurrent attacks of pseudogout were followed for 1 year before and 1 year after receiving oral colchicine 0.6 mg BID. "
2.	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/01/2013 - "Reply to the comment by Verhoeven et al. about the article "Efficacy of anakinra in articular chondrocalcinosis--report of three cases" Joint Bone Spine 2012;79:330-1." 01/01/2013 - "et al. "Efficacy of anakinra in articular chondrocalcinosis"." 05/01/2012 - "Efficacy of anakinra in articular chondrocalcinosis: report of three cases." 07/01/2023 - "In this 2-year retrospective case series, we characterise the calcium pyrophosphate deposition disease (CPPD) inpatient cohort at a single centre and assess the efficacy and safety of anakinra in its treatment. " 07/01/2023 - "A single-centre retrospective case series of Anakinra for incident calcium pyrophosphate deposition disease."
3.	MagnesiumIBA 10/24/2017 - "The aim was to assess serum magnesium levels in relation to prevalence of knee chondrocalcinosis in two population-based Chinese studies. " 01/01/2019 - "Acute pseudogout - Measure serum magnesium." 03/01/2018 - "Magnesium disorders can cause calcium pyrophosphate deposition disease: A case report and literature review." 10/24/2017 - "Subjects with lower levels of serum magnesium, even within the normal range, had higher prevalence of knee chondrocalcinosis in a dose-response relationship manner, suggesting that magnesium may have a preventive or therapeutic potential for knee chondrocalcinosis." 10/24/2017 - "We examined the relation of serum magnesium levels to prevalence of knee chondrocalcinosis using generalized estimating equations. "
4.	CalciumIBA 07/01/2021 - "Calcium pyrophosphate deposition disease (CPPD) benefited also from these new techniques, most of which can readily identify calcium crystals. " 05/01/2011 - "None of them had joint involvement atypical for OA or evidences of chondrocalcinosis in radiographic studies suggesting the presence of calcium-pyrophosphatedeposition-disease (CPPD). " 01/01/2021 - "While DECT has the potential to characterize knee intraarticular mineralization, this technique cannot yet accurately identify early calcium crystal deposition that is not visible as chondrocalcinosis on conventional CT." 01/01/2021 - "To assess the ability of dual-energy computed tomography (DECT) in identifying early calcium crystal deposition in menisci and articular cartilage of the knee, depending on the presence/absence of chondrocalcinosis seen on conventional CT. " 09/01/2020 - "Chondrocalcinosis is the radiographic appearance of calcium crystals in cartilage and other soft tissue. "
5.	Uric Acid (Urate)IBA 12/01/2020 - "Comment on: "Monosodium urate deposition in the articular cartilage and meniscus can mimic chondrocalcinosis" by Bousson et al. Joint Bone Spine 2020, 87:95-96." 01/01/2020 - "Monosodium urate deposition in the articular cartilage and meniscus can mimic chondrocalcinosis." 08/01/1992 - "There was no statistically significant relation for gender, meniscectomy, injury, uric acid concentration, chondrocalcinosis, smoking, and occupation related factors, except possibly standing." 02/01/1980 - "An association between urate gout and chondrocalcinosis has been suggested in several studies, but the situation remains ill-defined because of lack of appropriate controls, small numbers of patients studied, or retrospective investigation. " 08/01/2001 - "We conclude that CPPD in pseudogout and monosodium urate in gout may not polarize in the routine H&E-stained sections. "
6.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 07/01/2023 - "Adult inpatients with CPPD between 1st September 2020 and 30th September 2022 were identified by ICD-10 codes and confirmed based on clinical diagnosis and either CPP crystals on aspirate or chondrocalcinosis on imaging. " 12/01/2021 - "CPP crystal deposition, on the other hand, is a hallmark of chondrocalcinosis and is associated with aging and chondrocyte senescence. " 01/01/2021 - "The combined algorithm identified 50% more patients than the presence of CPP crystals; the latter captured a portion of definite pseudogout and missed probable pseudogout. " 01/01/2019 - "Plain x-ray of the calcified meniscus showed chondrocalcinosis consistent with CPP, while SPCCT showed and differentiated CPP and HA. " 10/01/2023 - "Differences in the Optical Response of MSU and CPP Crystals During Magnetic Orientation: Possibility of Diagnosing Gout and Pseudogout."
7.	Adrenocorticotropic Hormone (ACTH)FDA Link 04/01/1994 - "ACTH is a safe and effective treatment for acute gout and pseudogout, especially in patients with multiple medical problems." 01/01/2019 - "We included clinical trials or case studies/series where ACTH had been administered in human subjects as a treatment for acute gout or pseudogout. " 04/01/2014 - "We performed a systematic electronic search (Medline and ScienceDirect) using the keywords gout, treatment, ACTH, adrenocorticotropic hormone, and pseudogout. " 04/01/1994 - "To determine the effectiveness of adrenocorticotropic hormone (ACTH) for acute gouty arthritis and pseudogout in a population of patients with multiple coexisting medical problems. " 04/01/1994 - "The indications for using ACTH included congestive heart failure, chronic renal insufficiency, gastrointestinal bleeding, or no response to NSAID: All episodes of pseudogout resolved in an average of 4.2 days. "
8.	Proteins (Proteins, Gene)FDA Link 05/01/2016 - "A more complete understanding of this important protein may help to identify future therapeutic targets for the treatment of calcium pyrophosphate deposition disease." 10/01/1999 - "Exclusion of the gene for human cartilage intermediate layer protein in currently mapped calcium pyrophosphate dihydrate deposition syndromes." 08/28/2016 - "All the results revealed that the glycopolymer-protein materials described in this work, especially the conjugates with small molecular weight PMAG, possess significantly enhanced capacity to improve enzymatic activity, that the structure and property of PMAG play important roles in the tolerance of the conjugates to both environmental and biological stresses, and that the PMAG-PPase conjugate could potentially assist in the therapy of pseudogout. " 03/01/2016 - "ANKH mutations have been reported in inherited human disorders such as familial calcium pyrophosphate deposition disease (CPPD) and cranial metaphyseal dysplasia; however, research into the function of the ANKH protein has been more challenging. " 05/01/2016 - "This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyrophosphate deposition disease. "
9.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 07/01/2012 - "The use of conventional NSAIDs, radiographic progression of OA in the opposite femorotibial compartment of the knee, failure of the ACL, and aseptic loosening did not occur more frequently among patients with chondrocalcinosis. " 01/01/2009 - "A significant reduction in serum CRP levels at one week after use of nonsteroidal anti-inflammatory drugs (NSAIDs) is a good clue to differentiate pseudogout and post-infectious polyarthritis from PMR. " 01/01/2009 - "A promptly decreased serum CRP level by NSAIDs is a good clue to differentiate pseudogout and post-infectious polyarthritis from PMR. " 04/01/1994 - "The indications for using ACTH included congestive heart failure, chronic renal insufficiency, gastrointestinal bleeding, or no response to NSAID: All episodes of pseudogout resolved in an average of 4.2 days. " 12/01/1993 - "This article describes the clinical spectrum of gout and pseudogout and discusses the role of colchicine, NSAIDs, and uric acid--lowering agents in the management of different stages of gout. "
10.	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 06/01/1997 - "triamcinolone acetonide appears to be safe, well tolerated, and effective in the treatment of pseudogout. " 06/01/1997 - "To prospectively assess the efficacy of intramuscular (i.m.) triamcinolone acetonide in the treatment of pseudogout. " 06/01/1997 - "Fourteen patients with crystal proven pseudogout presenting with an acute attack within 5 days of onset were treated with intramuscular triamcinolone acetonide 60 mg and followed for 30 days. " 06/01/1997 - "Prospective use of intramuscular triamcinolone acetonide in pseudogout."

Therapies and Procedures

1.	Parathyroidectomy 05/01/2018 - "Pseudogout flare is a rare but known sequelae after parathyroidectomy. " 05/01/2018 - "Pseudogout - a rare manifestation of hungry bone syndrome after focused parathyroidectomy." 01/01/2017 - "Pseudogout attacks have been noted in the immediate post-operative period following parathyroidectomy, but has rarely been identified in the foot. " 01/01/2017 - "Acute pseudogout of the foot following Parathyroidectomy: a case report." 12/01/2008 - "We propose that otolaryngology units should be more aware of the unusual sequelae of pseudogout following parathyroidectomy; it can lead to a prompt referral and commencement of early treatment."
2.	Arthroplasty 06/01/2015 - "Because there was no long-term improvement in her clinical symptoms, she subsequently underwent arthroplasty of the right joint, with the white material clearly seen at surgery, and the biopsy examination confirmed the clinical and arthroscopic impression of pseudogout. " 03/01/2022 - "This study shows that the impact of a subclinical form of chondrocalcinosis may not be of clinical relevance in the context of arthroplasty. " 01/01/2019 - "Clinical Presentation, Management, and Prognosis of Pseudogout in Joint Arthroplasty: A Retrospective Cohort Study." 07/01/2012 - "Does primary or secondary chondrocalcinosis influence long-term survivorship of unicompartmental arthroplasty?" 03/01/2010 - "Pseudogout of the temporomandibular joint: immediate reconstruction with total joint arthroplasty."
3.	Therapeutics 06/01/2018 - "There is no standard regimen for long-term chronic therapies of pseudogout. " 08/01/2012 - "Patients with calcium pyrophosphate deposition disease sometimes require a continuous therapy. " 01/01/1999 - "Pseudogout is a recognized complication of thyroid replacement therapy, but association with Sjögren's syndrome has not been previously reported." 10/01/1985 - "[Chondrocalcinosis: clinical forms, diagnosis and therapy]." 10/10/2008 - "[Therapy for gout and pseudogout]."
4.	Replacement Arthroplasty 12/01/2010 - "Female sex, metacarpophalangeal joint involvement, and the presence of chondrocalcinosis were associated with a higher risk of early joint failure (i.e., the need for joint replacement surgery). " 01/01/2020 - "To assess the impact of knee chondrocalcinosis (CC) on the 5-year risk of joint replacement and disease progression in patients with knee osteoarthritis (OA). " 01/01/2017 - "Radiosynoviorthesis is effective in different type of peripheral arthritis like rheumatoid arthritis, inflammatory spondyloarthtropaties, gout, chondrocalcinosis, pigmented villo-nodular synovitis, recurrent knee effusion after total joint replacement, idiopathic knee joint effusion, osteoarthritis and secondary prevention of intraarticular bleeding in haemophilia. "
5.	Laminectomy 04/01/2003 - "After posterior decompressive laminectomy with removal of the calcified nodule, the symptom and sign relieved remarkedly and the pathology showed calcium pyrophosphate dihydrate deposition within the ligamentum flavum. " 03/01/2023 - "He ultimately was found to have severe cervical stenosis and pseudogout that were treated with a laminectomy and colchicine, respectively. "