Chondroblastoma

A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. It occurs primarily in the epiphyses of adolescents. It is relatively rare and represents less than 2% of all primary bone tumors. The peak incidence is in the second decade of life; it is about twice as common in males as in females. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1846)

Also Known As:

Networked: 130 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Osteosarcoma (Osteogenic Sarcoma)
3.	Chondrosarcoma
4.	Fibroma (Fibromatosis)
5.	Giant Cell Tumors (Giant Cell Tumor)

Experts

1.	Jundt, Gernot: 2 articles (12/2013 - 02/2002)
2.	Oda, Yoshinao: 2 articles (02/2013 - 01/2013)
3.	Rosa, Michele Attilio: 2 articles (11/2009 - 01/2009)
4.	Ieni, Antonio: 2 articles (11/2009 - 01/2009)
5.	Tuccari, Giovanni: 2 articles (11/2009 - 01/2009)
6.	Barresi, Valeria: 2 articles (11/2009 - 01/2009)
7.	Davies, A M: 2 articles (11/2008 - 07/2005)
8.	Imamura, Tetsuo: 2 articles (08/2008 - 01/2004)
9.	Aigner, T: 2 articles (02/2006 - 03/2002)
10.	Goto, Takahiro: 2 articles (01/2004 - 10/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chondroblastoma:

1.	Muramidase (Lysozyme)IBA 09/01/1995 - "Immunohistochemistry thus helped to distinguish chondroblastoma and osteosarcoma, in which lysozyme positivity would reside in macrophages but not within stromal cells. " 05/01/1993 - "The observation of positive reaction to S-100 protein (S-100), vimentin (Vim), alpha 1-antichymotrypsin (AACT) and lysozyme (Lyso) by the tumor cells of clear cell chondrosarcoma, similar to traditional chondrosarcoma and chondroblastoma, proves that this tumor has its origin in the cartilaginous tissue. " 07/01/1991 - "The observation of positive reaction to S-100 protein, vimentin, anti-alpha-chymotrypsin and Lysozyme by the tumor cells of clear cell chondrosarcoma, similar to chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. "
2.	calponinIBA 07/01/2009 - "A convincing immunoreactivity for calponin and/or actin in chondromyxoid fibromas and chondroblastomas may also be helpful in differentiating these tumors from chondrosarcomas." 02/01/2011 - "Cytokeratin-, calponin-, and p63-positive chondroblastoma with extensive soft tissue involvement and vascular invasion: a potential diagnostic dilemma." 07/01/2009 - "Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL-40. " 04/01/2003 - "The expression of alpha smooth muscle actin, muscle specific actin, desmin, h-caldesmon, and calponin was studied immunohistochemically in the following soft tissue and bone tumours and tumour-like lesions: muscle fibromatosis, inflammatory pseudotumours, chondroblastoma, enchondroma, chondrosarcoma, fibrous dysplasia, ossifying myositis, osteoblastoma, convential osteosarcoma, leiomyoma and leiomyosarcoma. "
3.	S100 Proteins (S 100 Protein)IBA 01/01/2011 - "Based on preoperative immunochemical studies showing positive reaction of multinucleated giant cells for S-100 protein, the final diagnosis was chondroblastoma. " 01/01/1996 - "Although the histogenesis of chondroblastoma is not completely understood, morphological findings as well as the observed reactivity with the S 100 protein indicate the chondroid origin. " 03/01/1985 - "These results suggest that immunohistochemical assessment of S-100 protein may be a method for diagnostically separating chondroblastoma from pathologic entities that could be histologically confused with it in the presence of limited biopsy material. " 03/01/1985 - "S-100 protein immunostaining in the differential diagnosis of chondroblastoma." 02/15/1988 - "S-100 protein was positive in both polygonal stromal cells and chondrocytes of chondroblastomas and in chondrocytes of mesenchymal chondrosarcoma. "
4.	Collagen Type II (Type II Collagen)IBA 02/01/2006 - "In contrast, immunohistochemical analysis failed to show staining of collagen type II in any of the 35 chondroblastomas. " 09/01/2002 - "Immunohistochemically, the expression of type II collagen was diffuse in 15 cases (75%) among total 20 chondroblastomas and 12 (85.7%) among total 14 CMFs. " 12/01/1999 - "An extensive analysis of the extracellular matrix composition and gene expression pattern of a large series of chondroblastoma cases shows, however, that type II collagen, which is the main component of any cartilage matrix, is not expressed by the neoplastic cells of this tumour entity and is not deposited into the extracellular tumour matrix. " 05/01/1999 - "S100 protein and type II collagen were expressed in CCC cells, chondroblastoma cells and CC cells. " 03/01/2002 - "These results characterise chondroblastomas and chondromyxoidfiibromas as skeletal neoplasms that have a different biology and which can be distinguished by matrix protein expression products: collagen type II, the typical marker of chondroblast differentiation, could only be detected in chondromyxoidfibromas, but not in chondroblastomas. "
5.	VimentinIBA 02/01/2006 - "In our study of a series of clear cell chondrosarcomas (n = 15) and chondroblastomas (n = 35), S100, vimentin, aggrecan and collagen type II were detected by immunohistochemistry. " 05/01/1993 - "The observation of positive reaction to S-100 protein (S-100), vimentin (Vim), alpha 1-antichymotrypsin (AACT) and lysozyme (Lyso) by the tumor cells of clear cell chondrosarcoma, similar to traditional chondrosarcoma and chondroblastoma, proves that this tumor has its origin in the cartilaginous tissue. " 07/01/1991 - "The observation of positive reaction to S-100 protein, vimentin, anti-alpha-chymotrypsin and Lysozyme by the tumor cells of clear cell chondrosarcoma, similar to chondrosarcoma and chondroblastoma, proves that this tumor has its origin from the cartilaginous tissue. " 03/01/1990 - "Chondroblastomas were shown to co-express vimentin, S-100 protein, neuron-specific enolase, and the epithelial markers recognized by CAM 5.2, EMA and a polyclonal cytokeratin antibody. "
6.	Histones (Histone)IBA 06/01/2015 - "Subsequent studies have identified high-frequency mutation of histone H3 to K36M in chondroblastomas and to G34W/L in giant cell tumors of bone, which are diseases of adolescents and young adults. " 12/01/2013 - "In 73 of 77 cases of chondroblastoma (95%), we found p.Lys36Met alterations predominantly encoded in H3F3B, which is one of two genes for histone H3.3. In contrast, in 92% (49/53) of giant cell tumors of bone, we found histone H3.3 alterations exclusively in H3F3A, leading to p.Gly34Trp or, in one case, p.Gly34Leu alterations. " 12/01/2013 - "A new report now describes frequent histone H3.3 alterations in chondroblastoma and giant cell tumor of bone, emphasizing the importance of this histone variant in pediatric cancers. " 06/02/2015 - "Significantly, the somatic missense mutations of the histone H3 variant, H3.3, are associated with childhood and young-adult tumors, such as pediatric high-grade astrocytomas, as well as chondroblastoma and giant-cell tumors of the bone. "
7.	DNA (Deoxyribonucleic Acid)IBA 10/01/1979 - "The nuclei of a chondroblastoma were also diploid and the Feulgen DNA content was normally distributed. " 06/01/1983 - "In 2 enchondromatoses and 2 benign chondroblastomas, the DNA content was diploid and showed a unimodal normal distribution. " 05/01/1981 - "In contrast, the stromal cells of the osteoclastomas and the chondroblastomas gave evidence of DNA synthesis, thus proving their proliferative capacity in both tumors. " 05/01/1981 - "A microspectrophotometric study of DNA content was carried out on cells from three types of bone tumor--osteoclastoma, chondroblastoma, and osteosarcoma--in all of which the formation of multinucleated giant cells occurs. " 11/01/1999 - "Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy."
8.	Aggrecans (Aggrecan)IBA 12/01/1999 - "The multifocal expression of aggrecan proteoglycan in most chondroblastomas explains the bluish, pseudo-chondroid appearance of some of the matrix-rich areas of chondroblastomas. " 02/01/2006 - "Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma." 02/01/2006 - "In our study of a series of clear cell chondrosarcomas (n = 15) and chondroblastomas (n = 35), S100, vimentin, aggrecan and collagen type II were detected by immunohistochemistry. "
9.	tau Proteins (tau Protein)IBA 08/01/1999 - "In the present study, 2 extraskeletal myxoid chondrosarcomas (EMCs), 6 chordomas, 6 chondrosarcomas, 3 myxoid chondrosarcomas of bone, 2 osteochondromas, 6 chondroblastomas, and 2 nonneoplastic adult articular cartilages were immunostained with monoclonal antibodies against tau proteins and tubulin. "
10.	TubulinIBA 08/01/1999 - "Although tubulin was detected in chondroblastomas (5/6), osteochondromas (2/2), chondrosarcomas (5/6), and myxoid-chondrosarcomas of bone (3/3), tau expression was absent in these tumors. " 08/01/1999 - "In the present study, 2 extraskeletal myxoid chondrosarcomas (EMCs), 6 chordomas, 6 chondrosarcomas, 3 myxoid chondrosarcomas of bone, 2 osteochondromas, 6 chondroblastomas, and 2 nonneoplastic adult articular cartilages were immunostained with monoclonal antibodies against tau proteins and tubulin. "

Therapies and Procedures

1.	Curettage 12/01/2002 - "Simple curettage was effective for local control during the initial treatment in most cases, but aggressive curettage and adjuvant treatment with alcohol and/or cement was useful for local control in recurrent chondroblastoma and chondroblastoma presenting with an aggressive behaviour." 11/01/2014 - "Endoscopic curettage is a promising new treatment for chondroblastoma. " 11/01/2008 - "Radiofrequency ablation for chondroblastoma provides an alternative to surgical curettage, and we have demonstrated both a clinical improvement in symptoms and the follow-up MRI appearances." 10/01/2003 - "The purpose of this study was to report the results of 10 cases of chondroblastomas of the bone treated with curettage and high-speed burring. " 03/01/2015 - "We present here a patient who underwent arthroscopic treatment for cement exposure caused by articular cartilage loss of the tibial plateau, which occurred after initial curettage and cementation for chondroblastoma of the proximal tibia. "
2.	Bone Transplantation (Bone Grafting) 09/01/2013 - "Managing chondroblastoma of the talus with curettage and bone grafting has shown good outcomes. " 04/01/2002 - "Endoscopic curettage without bone grafting is a promising new treatment for chondroblastoma." 07/01/2015 - "We report a young male with chondroblastoma of scaphoid treated with curettage, bone grafting and K-wire fixation. " 05/01/2014 - "Various methods for the treatment of chondroblastoma of bone have been used including simple curettage, or combined with bone grafting, in addition to the use of adjuvant therapy. " 08/01/2008 - "The trapdoor procedure enabled sufficient access to complete curettage and autologous cancellous bone grafting for the chondroblastoma of the femoral head. "
3.	Aftercare (After-Treatment) 01/01/2013 - "The patient was able to resume normal activities after treatment, and there was no recurrence of the chondroblastoma during a follow-up of 3 years." 11/01/2003 - "To evaluate the frequency of clinico-radiological presentation and the prognosis after treatment of chondroblastoma. " 03/01/1990 - "The present study is based on the histopathological and immunohistochemical examination of seven chondroblastomas, including one lung metastasis occurring 9 years after treatment. "
4.	Cryotherapy (Therapy, Cold) 05/01/2014 - "This study focuses on evaluating the role of intraregional extended curettage together with the use of adjuvant cryotherapy and autogenous bone grafting in the treatment of benign chondroblastoma of bone aiming to decrease the recurrence rate. " 05/01/2014 - "All patients with chondroblastoma included in this study underwent intralesional extended curettage, adjuvant cryotherapy using liquid nitrogen, and autogenous iliac crest bone grafting. "
5.	Transplants (Transplant) 05/01/2012 - "Chondroblastoma in a metatarsal treated with autogenous fibular graft: a case report." 02/01/2012 - "A free vascularized fibula graft is an excellent option for the reconstruction of a large femoral head defect after chondroblastoma resection." 02/01/2012 - "This article describes a case of surgical treatment of a chondroblastoma of the femoral head with the use of a free vascularized fibula graft. " 02/01/2012 - "Free vascularized fibula graft to treat chondroblastoma of the hip." 09/01/2008 - "We present a case of chondroblastoma of the carpal scaphoids that was treated through curretage of the lesion and filling with autologous osseous graft from the iliac crest."