Choline O-Acetyltransferase (Choline Acetyltransferase)

09/01/1999 - "To determine whether higher brain levels of choline acetyltransferase (ChAT) are associated with improved neuropsychological function in patients with Alzheimer disease (AD). "
09/01/2011 - "Genetic variation in the choline O-acetyltransferase gene in depression and Alzheimer's disease: the VITA and Milano studies."
01/05/2005 - "Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study."
02/07/1997 - "The study populations were also investigated for choline acetyltransferase (ChAT) activity, since reduced ChAT activity is an established biochemical hallmark in DS and Alzheimer disease (AD). "
07/01/1990 - "The hypothesis that the symptomatology of Alzheimer's disease is attributable to cholinergic dysfunction is supported by postmortem studies that have demonstrated reduced choline acetyltransferase (ChAT) activity across all areas of cerebral cortex and diminished numbers of perikarya in the basal forebrain nucleus basalis of Meynert. "

08/19/1983 - "There was also a significant reduction in the cholinergic marker choline acetyltransferase in cortex samples from the dementia cases."
01/01/1999 - "The biological substrate underlying the reduced cortical choline acetyltransferase (ChAT) in dementia with Lewy bodies (DLB) is incompletely understood. "
01/01/1999 - "Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology."
05/01/1997 - "Among DLB cases, neocortical Lewy body (LB) counts, modified Braak stages of NFT burden in the entorhinal cortex, neocortical NP counts, and loss of choline acetyltransferase (ChAT) activity all correlated with dementia severity. "
02/01/1995 - "Choline acetyltransferase activity was highly correlated with clinical dementia ratings across the neocortex of the AD cases. "

05/01/1981 - "We found a significant increase in the activity of choline acetyltransferase in the sinoatrial node in response to hypoxia after 7 or 14 days. "
02/01/2013 - "Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1α-related defense mechanisms."
07/01/1987 - "We studied the effect of early postnatal hypoxia-ischemia on cholinergic neurons in the developing rat forebrain using immunohistochemistry for choline acetyltransferase (ChAT). "
07/01/1987 - "Effects of postnatal hypoxia-ischemia on cholinergic neurons in the developing rat forebrain: choline acetyltransferase immunocytochemistry."
01/01/2013 - "Carbamylated erythropoietin ameliorates hypoxia-induced cognitive and behavioral defects with the generation of choline acetyltransferase-positive neurons."

01/23/2013 - "The purpose of this study was to investigate the location and level of peripherin expression in the central nervous system in response to transient global cerebral ischemia, and the resultant effect of peripherin expression on the cholinergic neurons and Choline acetyltransferase (ChAT) activity in this mouse model of ischemia. "
04/01/1989 - "Male Fischer-344 rats aged 6, 12, or 24 months were subjected to four-vessel occlusion cerebral ischemia to assess age-dependent ischemic vulnerability of cholinergic and GABAergic neurons based on choline acetyltransferase (EC 2.3.1.6) and glutamic acid decarboxylase (EC 4.1.1.15) activities. "
03/01/1989 - "Using experimental cerebral ischemia induced in rats with 4-vessel occlusion, the effects of 2-hour ischemia (ligation group) and 30-minute ischemia followed by 72-hour reperfusion (reperfusion group) on cholinergic system (ChS) was investigated with acetylcholine receptor (AChR), choline acetyltransferase (CAT) and acetylcholine esterase (AChE) as indicators of ChS in seven sections of the brain. "
04/01/2014 - "3-N-butylphthalide administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. "
01/01/2008 - "We investigated the immunohistochemical alterations of choline acetyltransferase (ChAT)-positive (cholinergic-positive), gamma-aminobutyric acid (GABA)ergic parvalbumin (PV)-positive, GABAergic nNOS (neuronal nitric oxide synthase)-positive interneurons, neuronal nuclei (NeuN)-positive spiny projection neurons, glial fibrillary acidic protein (GFAP)-positive strocytes and microglial response factor-1 (MRF-1)-positive microglia in the striatum after focal cerebral ischemia in rats. "

01/01/2005 - "Mutations in the choline acetyltransferase (CHAT) gene cause a presynaptic CMS associated with episodic apnea (CMS-EA). "
05/01/2003 - "The syndrome of congenital myasthenia with episodic apnea (CMS-EA) was previously found to be due to mutations in the choline acetyltransferase gene (CHAT). "
06/01/2002 - "Mutations in the gene encoding for choline acetyltransferase causes the CMS associated with episodic apnea."
02/13/2001 - "Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans."
07/01/2009 - "We present an infant with nine severe episodes of apnea in her first 6 months who underwent a prolonged evaluation before ptosis was evident, leading to a diagnosis of choline acetyltransferase deficiency, a form of congenital myasthenic syndrome. "