Cholesterol Oxidase

An enzyme that catalyzes the oxidation of cholesterol in the presence of molecular oxygen to 4-cholesten-3-one and hydrogen peroxide. The enzyme is not specific for cholesterol, but will also oxidize other 3-hydroxysteroids. EC 1.1.3.6.

Also Known As:

Networked: 30 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alapati, Kavitha: 1 article (07/2021)
2.	Handanahal, Savithri S: 1 article (07/2021)
3.	Akbar Ashkarran, Ali: 1 article (08/2019)
4.	Daemi, Sahar: 1 article (08/2019)
5.	Ghasemi, Shahram: 1 article (08/2019)
6.	El-Naggar, Noura El-Ahmady: 1 article (01/2018)
7.	El-Shweihy, Nancy M: 1 article (01/2018)
8.	Soliman, Hoda M: 1 article (01/2018)
9.	Blaes, Nelly: 1 article (01/2017)
10.	Dimo, Théophile: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 07/21/2021 - "Thus, cholesterol oxidase purified from a marine Streptomyces sp. AKHSS exhibits potent cytotoxicity at very low concentrations against human cancer cell lines. " 01/01/2018 - "The in vivo anticancer activity of cholesterol oxidase was evaluated against Ehrlich solid tumor model. " 01/01/2018 - "The purified cholesterol oxidase was evaluated for its in vitro anticancer activities against five human cancer cell lines. " 07/21/2021 - "All the ex vivo experiments portrayed the substantial inhibitory effect of the enzyme on HeLa cells suggesting that cholesterol oxidase of Streptomyces sp. AKHSS could be a prominent cancer chemotherapeutic agent." 01/01/2018 - "Compared with control mice, tumors growth was significantly inhibited in the mice injected with cholesterol oxidase alone, doxorubicin alone and cholesterol oxidase/doxorubicin combination by 60.97%, 72.99% and 97.04%; respectively. "
2.	Amyloid Plaque 01/01/2009 - "Senile plaques were said to be enriched in cholesterol in a few studies using the cholesterol probe filipin and a histoenzymatic method based upon cholesterol oxidase activity. "
3.	Hypoxia (Hypoxemia) 03/01/2007 - "Hence, this study tested the impact of LPS 'preconditioning' (LPS-PC; 18 or 72 h earlier) on: (i) selected renal inflammatory mediators (tumor necrosis factor (TNF)-alpha, interleukin-10 (IL-10), monocyte chemotactic protein-1 (MCP-1), inducible nitric oxide synthase (iNOS), Toll-like receptor 4 (TLR4); protein or mRNA); (ii) cholesterol homeostasis (a stress reactant); and (iii) isolated proximal tubule (PT) vulnerability to hypoxia or membrane cholesterol (cholesterol oxidase/esterase) attack. "
4.	Hemolysis 06/16/1997 - "pseudotuberculosis are cooperative partners in the hemolysis of sheep erythrocytes, traceable to the cholesterol oxidase of the former, and phospholipase D of the latter. " 04/01/1988 - "The presence of 1 mM Mg2+ in the assay buffer was essential to prevent hemolysis of cells treated with cholesterol oxidase perturbed the cells, resulting in an accelerated rate of apparent transbilayer movement. " 12/01/1987 - "Cholesterol measurement by cholesterol oxidase and quinoneimine dye production is subject to interference by haemolysis; provided that serum haemoglobin is less than 200 mg/dl, the cholesterol underestimate is less than 5%. " 09/01/1994 - "The haemolytic activity of growing strains, but not of cell-free preparations, was partially inhibited by lecithin but enhanced by cholesterol; however, cholesterol oxidase (CO) activity, known to mediate cooperative lysis of RBC sensitized with sphingomyelin-specific phospholipases C or D of some other species, did not contribute to the direct haemolysis caused by R. "
5.	Hypercholesterolemia 01/01/1982 - "[Effect of the cholesterol oxidase formed by Actinomyces lavendulae on hypercholesterolemia in rabbits]." 05/01/1981 - "[Effect of cholesterol oxidase on the involution of experimental hypercholesterolemia in rabbits]." 01/01/1978 - "[Effect of Actinomyces lavendulae cholesterol oxidase on hypercholesteremia in guinea pigs]."

Related Drugs and Biologics

1.	Cholesterol
2.	Enzymes
3.	Proteins (Proteins, Gene)
4.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
5.	Toll-Like Receptor 4
6.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
7.	Interleukin-10 (Interleukin 10)
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Messenger RNA (mRNA)
10.	Filipin (Filipin III)

Related Therapies and Procedures

1.	Therapeutics
2.	Electrodes (Electrode)