Cholesterol Esters (Cholesteryl Esters)

Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.

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Networked: 571 relevant articles (9 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tugnoli, V: 7 articles (08/2004 - 01/2001)
2.	Tosi, M R: 7 articles (08/2004 - 01/2001)
3.	Makarov, V K: 5 articles (10/2012 - 01/2003)
4.	Reggiani, A: 5 articles (07/2004 - 03/2002)
5.	Rudel, Lawrence L: 4 articles (10/2014 - 02/2003)
6.	Trinchero, A: 4 articles (07/2004 - 01/2001)
7.	Dullaart, Robin P F: 3 articles (01/2015 - 12/2008)
8.	de Vries, Rindert: 3 articles (01/2015 - 12/2008)
9.	Hula, N M: 3 articles (11/2014 - 01/2001)
10.	Davies, Michael J: 3 articles (01/2011 - 09/2003)

Related Diseases

1.	Atherosclerosis 06/01/1977 - "The current studies demonstrate that the unregulated uptake of LDL-cholesteryl esters by human aortic smooth muscle cells can reproduce in vitro the major biochemical and morphological alterations that occur within smooth muscle cells in vivo during the process of atherosclerosis." 12/01/2012 - "Large amounts of cholesterol esters accumulate in macrophages and smooth muscle cells of blood vessel walls resulting in the initial stages of atherosclerosis. " 06/01/2009 - "ACAT catalyzes the formation of cholesteryl esters (CE) in monocytes/macrophages, and it promotes the foam cell formation at the early stage of atherosclerosis. " 01/01/2008 - "Accumulation of cholesteryl esters within macrophages constitutes the hallmark of foam cells during atherogenesis. " 12/01/2007 - "Accumulation of cholesterol esters leads to pathological changes connected with atherosclerosis. "
2.	Stroke (Strokes) 08/01/2013 - "N-6 and n-3 fatty acid cholesteryl esters in relation to incident stroke in a Dutch adult population: a nested case-control study." 08/01/2013 - "We assessed the associations of plasma n-6 and n-3 PUFA in cholesteryl esters with the risk of total stroke and stroke subtypes in Dutch adults. " 12/01/2006 - "Higher proportions of palmitic (16:0), palmitoleic (16:1), and oleic acid (18:1) in cholesterol esters were associated with an increased risk, whereas a higher proportion of linoleic acid (18:2 n-6) was protective against stroke/TIA. " 01/01/1991 - "The obtained results indicate that in stroke cases the necrotic focus as well as contralateral brain hemisphere are characterized by a marked decrease of cholesterol and cerebrosides content and an increase of lysophosphatidylcholine and cholesterol esters in the myelin fraction. " 10/29/1975 - "Analysis of long-chain acids or human plasma phosphatidylcholines (lecithins) and cholesteryl esters by glass open tubular capillary column gas chromatography for stroke patients and for normal subjects."
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2000 - "The study of nonspecific internalization of cholesteryl esters by the Hep G2 hepatoma cells." 10/01/2007 - "Total-HDL containing [3H]E2-FAE or [3H]cholesterol esters was isolated by sequential density ultracentrifugation and then incubated with Fu5AH rat hepatoma cells for various time points. " 02/24/1993 - "Human Hep G2 hepatoma cells also selectively take up HDL cholesteryl esters. " 01/25/1984 - "Compound 58-035 (3-[decyldimethylsilyl]-N-[2-(4-methylphenyl)-1-phenylethyl]pro panamide) has been found to inhibit the accumulation of cholesteryl esters in both rat hepatoma (Fu5AH) cells and arterial smooth muscle cells in culture. " 02/15/1982 - "Rat hepatoma cells, Fu5AH, were loaded with cholesterol esters by incubation in medium supplemented with hyperlipemic rabbit serum. "
4.	Hypercholesterolemia 09/01/1992 - "Animal studies have demonstrated that hypercholesterolemia leads to the development of fibromuscular atherosclerotic lesions that are characterized by the intimal accumulation of cholesterol esters in macrophage foam cells and focal proliferation of smooth muscle cells (SMCs). " 11/01/1982 - "Studies have been performed on groups of mini-pigs 21-23 months of age, which after 18 months of hypercholesterolemia (approximately 10 mmol) had developed raised atherosclerotic lesions with high levels of cholesterol esters, especially in the abdominal aorta and the coronary arteries. " 05/01/1999 - "This may be due to the increased load of LDL with cholesterol esters as a substrate for oxidation in hypercholesterolemia. " 01/01/1991 - "Cholesterol esters often deposit during hypercholesterolemia. " 02/01/1990 - "Cholesterol esters often deposit during hypercholesterolemia. "
5.	Xanthomatosis (Xanthoma) 01/01/1977 - "-- Cholesterol esters (EC) are prevalent in xanthomas and in normal skin the triglycerides fraction. " 07/01/1989 - "Treatment with probucol, a widely used lipid-lowering agent, is associated with a significant reduction of high density lipoprotein (HDL) cholesterol levels, but with an apparently improved removal of cholesteryl esters from tissues (e.g., from tendon xanthomas). "

Related Drugs and Biologics

1.	Lipoproteins (Lipoprotein)
2.	Cholesterol
3.	Probucol (Lorelco)
4.	Phospholipids
5.	IDL Lipoproteins (Lipoprotein, IDL)
6.	Apolipoproteins E (ApoE)
7.	Cerebrosides
8.	HDL Cholesterol
9.	Linoleic Acid (Linoleate)
10.	Oleic Acid (Oleate)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Photochemotherapy (Photodynamic Therapy)
3.	Intraperitoneal Injections
4.	Hypophysectomy
5.	Hepatectomy