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Cholesterol Side-Chain Cleavage Enzyme (CYP11A1)

A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
Also Known As:
CYP11A1; Cholesterol Monooxygenase (Side-Chain-Cleaving); 20,22-Desmolase; CYP 11A1; Cytochrome P450 11A1; Cytochrome P450scc; 20,22 Desmolase; Cholesterol Side Chain Cleavage Enzyme; Cytochrome P 450 CYP11A1; Cholesterol Desmolase; Cytochrome P-450 CYP11A1; Cytochrome P-450(scc); Cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
Networked: 205 relevant articles (3 outcomes, 26 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Slominski, Andrzej T: 8 articles (05/2020 - 03/2010)
2. Tuckey, Robert C: 6 articles (05/2020 - 03/2010)
3. Achermann, John C: 5 articles (01/2022 - 03/2008)
4. Ge, Ren-Shan: 5 articles (10/2021 - 01/2021)
5. Janjetovic, Zorica: 5 articles (05/2020 - 03/2010)
6. Li, Wei: 5 articles (07/2015 - 03/2010)
7. Buonocore, Federica: 4 articles (01/2022 - 01/2019)
8. Wang, Yiyan: 4 articles (10/2021 - 01/2021)
9. Kim, Tae-Kang: 4 articles (05/2020 - 12/2010)
10. Gelfand, Erwin W: 4 articles (01/2020 - 05/2013)

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