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Cholera Toxin

An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Also Known As:
Cholera Enterotoxin CT; Cholera Exotoxin; Cholera Toxin A Subunit; Cholera Toxin B Subunit; Procholeragenoid; Enterotoxin CT, Cholera; Exotoxin, Cholera; Toxin A, Cholera; Toxin B, Cholera; Toxin, Cholera; Cholera Toxin A; Cholera Toxin B; Cholera Toxin Protomer A; Cholera Toxin Protomer B; Cholera Toxin Subunit A; Cholera Toxin Subunit B; Choleragen; Choleragenoid
Networked: 1392 relevant articles (64 outcomes, 93 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Qadri, Firdausi: 25 articles (01/2021 - 08/2003)
2. Harris, Jason B: 22 articles (12/2021 - 08/2005)
3. Calderwood, Stephen B: 22 articles (01/2021 - 08/2003)
4. Ryan, Edward T: 21 articles (01/2021 - 08/2003)
5. Holmgren, Jan: 17 articles (01/2019 - 08/2002)
6. Chowdhury, Fahima: 14 articles (01/2021 - 11/2005)
7. Khan, Ashraful I: 11 articles (01/2019 - 08/2005)
8. Holmgren, J: 10 articles (07/2013 - 10/2000)
9. Bhuiyan, Taufiqur Rahman: 7 articles (01/2021 - 10/2013)
10. Withey, Jeffrey H: 7 articles (01/2021 - 12/2005)

Related Diseases

1. Cholera
2. Infections
3. Diarrhea
4. Human Influenza (Influenza)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Vaccines
2. Antigens
3. Proteins (Proteins, Gene)
4. Peptides (Polypeptides)
5. Antibodies
6. Immunoglobulin A (IgA)
7. Antitoxins
8. Cholera Vaccines
9. Ovalbumin
10. Membrane Proteins (Integral Membrane Proteins)

Related Therapies and Procedures

1. Fluid Therapy (Oral Rehydration Therapy)
2. Oral Administration
3. Intranasal Administration
4. Microspheres (Microsphere)
5. Injections