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Chlorpropamide

Subscribe to New Research on Chlorpropamide

A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)

Also Known As:

Apo-Chlorpropamide; Apotex Brand of Chlorpropamide; Byk Gulden Brand of Chlorpropamide; Diabinese; Farmasierra Brand of Chlorpropamide; Glucamide; Insogen; Meldian; Pfizer Brand of Chlorpropamide; Clorpropamid; Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)-

Networked: 515 relevant articles (12 outcomes, 25 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Urea: 9142
  - Sulfonylurea Compounds: 29
    - Chlorpropamide: 515
- Sulfur Compounds: 135
  - Sulfones: 136
    - Sulfonylurea Compounds: 29
      - Chlorpropamide: 515
        API 2: 13
        2-hydroxychlorpropamide
        cyclohexylbutanoyl-N-hydroxyethylglucamide
        N(1)-ethylchlorpropamide

Experts

1.	Azeez, O I: 2 articles (12/2010 - 09/2010)
2.	Oyagbemi, A A: 2 articles (12/2010 - 09/2010)
3.	Nagasawa, H T: 2 articles (11/2001 - 01/2001)
4.	Rekha, G K: 2 articles (11/2001 - 01/2001)
5.	Sládek, N E: 2 articles (11/2001 - 01/2001)
6.	Lee, M J: 2 articles (11/2001 - 01/2001)
7.	Moshi, M J: 2 articles (01/2000 - 01/2000)
8.	Moores, Kevin G: 1 article (03/2011)
9.	Fravel, Michelle A: 1 article (03/2011)
10.	Ross, Mary B: 1 article (03/2011)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 05/01/1985 - "[The blush or flush caused by chlorpropamide/alcohol (CAF) in non-insulin-dependent diabetes mellitus]." 09/01/1984 - "Chlorpropamide, a sulfonylurea compound used in the treatment of diabetes mellitus, type II, has been implicated as the cause of untoward reactions involving the hematopoietic, cutaneous, and gastrointestinal systems. " 01/01/1984 - "[Chlorpropamide-alcohol test as a marker of vascular complications of non-insulin-dependent diabetes mellitus]." 06/01/1982 - "[Chlorpropamide-alcohol flush test in non-insulin-dependent diabetes mellitus in young age (MODY type)]." 05/01/1976 - "Chlorpropamide and fibrinolytic activity in maturity onset diabetes mellitus."
2.	Diabetes Insipidus 01/01/1991 - "The present in vitro microperfusion study examined whether chlorpropamide (CPM) has a direct effect on hydraulic conductivity (Lp x 10(-6) cm/atm.sec) and 14C-urea permeability (Pu x 10(-5) cm/sec) in the middle and distal inner medullary collecting duct (IMCD) obtained from acutely water-loaded Wistar rats and rats homozygous for diabetes insipidus (DI). " 01/01/1970 - "Studies on the mechanism of "chlorpropamide antidiuresis" in diabetes insipidus." 10/01/1983 - "Chlorpropamide action on renal concentrating mechanism in rats with hypothalamic diabetes insipidus." 02/15/1983 - "Chlorpropamide in pregnancy and transient neonatal diabetes insipidus." 03/01/1982 - "The use of chlorpropamide in diabetes insipidus in children."
3.	Diabetes Mellitus 01/01/1986 - "[Studies of the functional state of blood vessels in various types of diabetes mellitus using the chlorpropamide-alcohol test]." 04/01/1967 - "Chlorpropamide in the treatment of diabetes mellitus--a long term study." 03/01/1961 - "Further studies on the action of chlorpropamide in diabetes mellitus." 03/30/1959 - "Clinical and experimental studies with chlorpropamide in diabetes mellitus, in normal individuals, and in nondiabetics with hepatic disease." 03/30/1959 - "Studies on the use of chlorpropamide in patients with diabetes mellitus."
4.	Hypoglycemia (Reactive Hypoglycemia) 12/01/1970 - "Studies in patients with chlorpropamide-induced hypoglycemia." 01/16/1966 - "[Study of an induced hypoglycemia test by use of intravenous chlorpropamide]." 06/01/2004 - "Chlorpropamide has caused serious hypoglycemia in seniors to a greater extent than some other agents. " 03/01/1999 - "The action time of chlorpropamide is very long, usually from 20 to 60 hours, therefore special care should be taken for hypoglycemia. " 01/01/1999 - "Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. "
5.	Flushing 01/01/1981 - "Chlorpropamide-alcohol flushing seems to be related to a relative protection against late complications in diabetes and the test might be used to find patients at risk." 07/01/1987 - "Thus, among young, healthy non-diabetic adults chlorpropamide alcohol flushing would appear to be a normal phenomenon." 07/01/1987 - "No subject was negative for chlorpropamide alcohol flushing, as defined by the following criteria: facial temperature rise of 35% or more of maximum possible rise, observer assessment or subject assessment. " 07/01/1987 - "It is known, however, that the frequency of facial flushing with alcohol and the temperature response depend upon both the plasma level of chlorpropamide and the starting facial temperature [10]. " 07/01/1987 - "Chlorpropamide alcohol flushing: a normal response?"

Related Drugs and Biologics

1.	Glyburide (Glibenclamide)
2.	Glucose (Dextrose)
3.	Insulin (Novolin)
4.	Glipizide (Glucotrol)
5.	Metformin (Glucophage)
6.	Vasopressins (Vasopressin)
7.	Chlorothiazide
8.	Clofibrate
9.	Carbamazepine (Tegretol)
10.	Biguanides

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Oral Administration
3.	Parathyroidectomy
4.	Total Parenteral Nutrition
5.	Pancreatectomy