Chlorothiazide

02/03/1958 - "Chlorothiazide in hypertension: studies on its mode of action."
08/01/1962 - "Acute systemic and coronary hemodynamic effects of chlorothiazide in subjects with systemic arterial hypertension."
12/01/1961 - "Mode of action of chlorothiazide in the reduction of blood pressure in hypertension."
07/01/1961 - "Chlorothiazide in treatment of arterial hypertension."
06/01/1961 - "Effect of chlorothiazide on blood pressure and blood flow at rest and on exercise in patients with arterial hypertension."

02/23/1980 - "It was as effective as chlorothiazide in the control of cardiac failure and was well tolerated by the patients. "
05/01/1959 - "[Chlorothiazide in the treatment of cardiac failure]."
05/01/1959 - "Clinical experience with chlorothiazide in the treatment of congestive heart failure."
04/01/1959 - "Chlorothiazide in the treatment of severe congestive heart failure."
01/01/1958 - "Chlorothiazide in congestive heart failure."

09/01/1981 - "The previous finding that chlorothiazide (about 250 mg/day) induces a sustained reduction in the polyuria of homozygous Brattleboro (BB) female rats, as well as an increase to about 250% of plasma renin activity was confirmed. "
01/01/1979 - "The polyuria of homozygous Brattleboro (BB) female rats is halved when they are given chlorothiazide (about 250 mg/day) or furosemide (about 60 mg/day) orally for one day. "
04/01/1974 - "Severe polyuria (more than 6 liter/day) was unresponsive to trials of vasopressin and chlorpropamide, but improved on chlorothiazide. "
11/01/1992 - "Neither fluid restriction and sodium substitution, nor administration of hydro-chlorothiazide/indomethacin affected natriuresis and polyuria. "

01/01/2020 - "Compared to metolazone (4.6 ± 2.7 kg), neither IV chlorothiazide (5.8 ± 2.7 kg; 1.2 kg [95% confidence interval (CI)]: -2.9 to 0.6; p = 0.292) nor tolvaptan (4.1 ± 3.3 kg; 0.5 kg [95% CI: -1.5 to 2.4; p = 0.456) resulted in more weight loss at 48 h. "
01/01/2020 - "In this moderately sized DR trial, weight loss was excellent with the addition of metolazone, IV chlorothiazide, or tolvaptan to loop diuretics, without a detectable between-group difference. "
10/01/1983 - "Infants given furosemide experienced a postnatal weight loss nearly identical to that in infants who were deemed not to need a diuretic; infants given chlorothiazide lost weight more slowly and had significantly greater body weight on postnatal days 4 and 5. Four factors were independently correlated with improved survival: furosemide usage, high birth weight, low initial mean airway pressure, and the absence of intraventricular hemorrhage. "

03/01/1958 - "Chlorothiazide as an adjunct in the treatment of hypertensive cardiovascular disease."
06/01/2017 - "CONCLUSIONS All thiazide-based medicines available in New Zealand are effective in terms of cardiovascular disease outcomes compared with placebo when used for treating hypertension, with the exception of chlorothiazide. "
06/01/2017 - "All thiazide-based diuretics have been reported in at least one trial showing them to be more effective than placebo for cardiovascular disease outcomes, with the exception of chlorothiazide. "