Chloroprene

09/01/1989 - "In a previous report by the authors, positive results in both case-control study mouse lung tumor induction short-term test of chloroprene for carcinogenicity was conducted to determine whether chloroprene monomer itself could induce tumor. "
04/01/1999 - "The present study was designed to characterize genetic alterations in the K- and H-ras proto-oncogenes in chloroprene-induced lung and HG neoplasms. "
06/01/1989 - "In the present study a short-term test for the induction of mouse lung tumor by chloroprene was conducted to confirm whether chloroprene monomer itself can induce tumors. "
11/01/2019 - " and methods: Female B6C3F1 mice were the most sensitive species/gender for lung tumors in the 2-year bioassay conducted with chloroprene. "
10/01/2014 - "A constrained maximum likelihood approach to evaluate the impact of dose metric on cancer risk assessment: application to β-chloroprene."

01/01/1998 - "The study defined a "dose-effect" correlation between exposure to chloroprene and death with liver cancer."
01/01/2002 - "The findings are reliably higher risk of morbidity and mortality with hepatic cancer, dose--effect dependence between chloroprene exposure and occurrence of and mortality with hepatic cancer."
06/01/2001 - "Our results did not confirm the excess of risk of liver cancer discovered during other cohort studies aiming to evaluate the role of chloroprene. "
01/01/2001 - "Increased mortality with liver cancer and lympholeucosis was revealed among workers contacting chloroprene."
01/01/2000 - "A direct "dose-effective" correlation was established between liver cancer risk and length of record for occupational exposure to chloroprene. "

12/01/1977 - "Likewise, several studies have indicated significant excesses of chromosomal aberrations as well as adverse effects on reproductive function following male exposure to chloroprene. "
03/01/1988 - "and below, chloroprene neither induced a significant increase in chromosomal aberrations (CA), sister chromatid exchanges (SCE) or micronucleated erythrocytes, nor significantly altered the rate of erythropoiesis or of bone marrow cellular proliferation kinetics. "
01/01/1990 - "In one study, we observed unusual dose-response in lymphocyte chromosome aberration frequencies after exposure of mice to low doses of a chemical mixture (benzene, chloroprene, epichlorohydrin, and xylene). "

01/01/1978 - "A study was undertaken to determine whether exposure to chloroprene increases the risk of lung cancer. "
04/01/1999 - "K-ras mutations were detected in 80% of chloroprene-induced lung neoplasms (37/46) compared with only 30% in spontaneous lung neoplasms (25/82). "
01/01/1978 - "However, the absence of excess lung cancer mortality in other high exposure occupational groups indicates that chloroprene exposure does not increase the risk of lung cancer."
01/01/1972 - "[Lung cancer morbidity among persons working with chloroprene]."
04/15/2016 - "The specific molecular mechanism of carcinogenesis by chloroprene in lung tissues still remains obscure, and specific candidate therapeutic targets for lung cancer are lacking. "

01/01/1998 - "NTP Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)."
04/15/2016 - "Seven hub genes that were critical for the carcinogenesis of chloroprene in lung tissue were ultimately identified, including Cftr, Hip1, Tbl1x, Ephx1, Cbr3, Antxr2 and Ccnd2. "
04/15/2016 - "Twelve gene modules with multiple biological activities were related to the carcinogenesis of chloroprene in lung tissue. "
02/01/2013 - "To identify potential key events in the mode of action of chloroprene lung tumorigenesis, dose-response and time-course gene expression microarray measurements were made in the lungs of female mice and female rats. "
04/15/2016 - "The specific molecular mechanism of carcinogenesis by chloroprene in lung tissues still remains obscure, and specific candidate therapeutic targets for lung cancer are lacking. "