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Proguanil (Paludrine)

A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.

Also Known As:

Paludrine; Astra Brand of Chloroguanide Hydrochloride; AstraZeneca Brand of Chloroguanide Hydrochloride; Bigumal; Chloriguane; Chloroguanide Hydrochloride; Paludrin; Proguanil Hydrochloride; Zeneca Brand of Chloroguanide Hydrochloride; Hydrochloride, Chloroguanide; Hydrochloride, Proguanil; Chlorguanid; Chloroguanide; Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-

Networked: 322 relevant articles (45 outcomes, 44 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amidines: 11
  - Guanidines: 20
    - Biguanides: 294
      - Proguanil: 322
        atovaquone-proguanil: 136
        malarone: 56
        cycloguanil: 46
        dapsone drug combination chloroguanil: 43
        chlorproguanil: 23
        PS 15: 11
        Preparation ABP

Experts

1.	Kain, Kevin C: 5 articles (02/2007 - 01/2003)
2.	Overbosch, D: 3 articles (09/2002 - 02/2000)
3.	Chulay, J D: 3 articles (07/2001 - 11/2000)
4.	Lalloo, David G: 2 articles (05/2013 - 02/2007)
5.	Schlagenhauf, Patricia: 2 articles (03/2013 - 01/2009)
6.	Jick, Susan S: 2 articles (03/2013 - 01/2004)
7.	Meier, Christoph R: 2 articles (03/2013 - 01/2004)
8.	Dinter, Domagoj: 2 articles (01/2013 - 11/2010)
9.	Gajski, Goran: 2 articles (01/2013 - 11/2010)
10.	Garaj-Vrhovac, Vera: 2 articles (01/2013 - 11/2010)

Related Diseases

1.	Malaria 01/01/1988 - "This regimen was the most effective in preventing malaria attacks in the previous 12 months, even though over half those on proguanil alone were taking an inadequate dose. " 08/15/2015 - "Protective efficacy against malaria, compared with daily proguanil, was 61% (95% confidence interval, 3%-84%) for MQAS and 36% (40%-70%) for SPAQ. " 05/01/1997 - "None of the 11 patients treated with proguanil were cured of malaria and their phenotype status did not affect the treatment outcome. " 01/01/1992 - "The study shows the importance of malaria in an endemic area among expatriates despite the observance of chemoprophylactics regimens including proguanil." 01/01/1948 - "Trials of Causal Prophylaxis of Malaria with Paludrine."
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 05/01/2002 - "Polyclonal Plasmodium falciparum malaria in travelers and selection of antifolate mutations after proguanil prophylaxis." 12/01/1997 - "The antifolate proguanil is commonly used in the prophylaxis and treatment of Plasmodium falciparum malaria. " 05/01/1997 - "Disposition of proguanil in Thai patients with uncomplicated falciparum malaria." 03/01/1988 - "The data were suggestive that proguanil may have some causal prophylactic effect against falciparum malaria. " 03/01/1988 - "Among 85 children taking proguanil for 524 human-weeks, there were 17 cases of falciparum malaria and 11 cases of vivax. "
3.	Infection 04/01/1999 - "To study this, 95 subjects with uncomplicated Plasmodium falciparum or Plasmodium vivax infections in Vanuatu received proguanil treatment for 3 days (adult relative dose of 300-500 mg/day) and were followed up for 28 days. " 06/01/1999 - "vivax infections, received proguanil treatment for 3 days in daily doses corresponding to adult doses of 300-500 mg. Capillary blood samples were collected on filter paper for determining both human CYP2C19 mutations by polymerase chain reaction and mutation-specific restriction enzyme digestion and blood concentrations of proguanil and its metabolites by high-performance liquid chromatography. " 06/18/1949 - "Proguanil prophylaxis and inter-current infection." 03/01/1949 - "Development of resistance to chlorguanide (paludrine) during treatment of infections with Plasmodium cynomolgi." 01/15/1949 - "Paludrine in prophylaxis and treatment of malarial infections caused by a West African strain of P. "
4.	Vivax Malaria 03/01/1949 - "The suppressive action of paludrine in benign tertian (vivax) malaria." 05/01/1948 - "The therapeutic effectiveness of large doses of paludrine in acute attacks of sporozoite-induced vivax malaria, Chesson strain." 01/01/1947 - "The suppressive and schizonticidal value of paludrine (100 mg.) in vivax malaria." 01/01/1986 - "In this geographical location, where malaria transmission is now light, a combination of strict personal antimosquito measures plus proguanil 200 mg daily produced effective, safe protection, with only a single case of vivax malaria occurring. " 04/01/1999 - "The results suggest that the parent compound proguanil has significant intrinsic efficacy against falciparum and vivax malaria independent of the metabolite cycloguanil."
5.	Splenomegaly 08/24/1974 - "After the remission of symptoms and reduction in spleen size while on proguanil therapy four patients with the tropical splenomegaly syndrome defaulted from treatment. " 12/01/1998 - "All patients had splenomegaly greater than 10 cm. They were given proguanil 100 mg/day for a minimum of 6 months. " 03/01/1995 - "Massive splenomegaly responsive to proguanil and with features of hairy cell leukaemia." 08/24/1974 - "Relapses after withdrawal of proguanil treatment in tropical splenomegaly syndrome." 12/01/1970 - "Long-term proguanil therapy in idiopathic tropical splenomegaly."

Related Drugs and Biologics

1.	Atovaquone (Mepron)
2.	Chloroquine (Aralen)
3.	Mefloquine (Lariam)
4.	cycloguanil
5.	Dapsone
6.	Antimalarials (Antimalarial Agents)
7.	sulfadoxine-pyrimethamine (Fansidar)
8.	Pyrimethamine (Daraprim)
9.	Proguanil (Paludrine)
10.	malarone

Related Therapies and Procedures

1.	Chemoprevention
2.	Protective Clothing
3.	Ambulatory Care (Outpatient Care)
4.	Drug Therapy (Chemotherapy)
5.	Mosquito Nets