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Chlormadinone Acetate (Chlormadinone)

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An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.

Also Known As:

Chlormadinone; Chlormadinon Acetate; Chlormadinone Acetate, (9 beta,10 alpha)-Isomer; Neo-Eunomin; Acetate, Chlormadinon; Acetate, Chlormadinone; Neo Eunomin; NeoEunomin; Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro-

Networked: 175 relevant articles (18 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Pregnanes: 3
    - Pregnadienes
      - Chlormadinone Acetate: 175
        Ovosiston: 23
        osaterone acetate: 17
        Non-Ovlon: 10
        Belara: 9
        chlormadinol acetate: 7
        chlormadinol acetate-3-O-alpha-arabinofuranoside: 5
        ethinylestradiol-chlormadinone acetate: 4
        delmadinone: 3
        chlorsuperlutin: 1
        2-azachlormadinone acetate
        3-O-arabinofuranosylchlormadinol acetate
        3-O-glucosylchlormadinol acetate
        3-O-rhamnosylchlormadinol acetate
        3alpha-hydroxy chlormadinone acetate
        6-chloro-16-methylene-17 alpha-hydroxy-19-nor-4,6- pregnadiene-3,20-dione 17-acetate
        chlormadinone-17-acetate 3 beta-hemisuccinate
        depochlormadinone acetate
        hydromadinone acetate
  - Chlorinated Steroids
    - Chlormadinone Acetate: 175

Experts

1.	Furuya, Ryoji: 4 articles (01/2013 - 03/2005)
2.	Hirao, Yoshihiko: 4 articles (01/2013 - 05/2004)
3.	Siddique, Yasir Hasan: 4 articles (11/2008 - 11/2004)
4.	Afzal, Mohammad: 4 articles (11/2008 - 11/2004)
5.	Murakoshi, M: 4 articles (08/2001 - 04/2000)
6.	Ohashi, Yasuo: 3 articles (01/2013 - 05/2004)
7.	Miyazawa, Katsuhito: 3 articles (01/2013 - 05/2006)
8.	Shibata, Yasuhiro: 3 articles (01/2013 - 04/2011)
9.	Fujimoto, Kiyohide: 3 articles (01/2013 - 05/2006)
10.	Arowojolu, Ayodele O: 3 articles (01/2012 - 01/2009)

Related Diseases

1.	Acne Vulgaris 01/01/2008 - "Effects of an oral contraceptive containing chlormadinone and ethinylestradiol on acne-prone skin of women of different age groups: an open-label, single-centre, phase IV study." 01/01/1970 - "An antiandrogen delta 1 chlormadinone acetate in acne: lack of effect topically." 01/01/2008 - "The highly statistically significant improvements in clinical findings and various biophysical skin parameters observed in this study suggest that the antiandrogenic oral contraceptive chlormadinone/ethinylestradiol may be a major therapy option in women with acne-prone skin who request hormonal contraception." 06/01/2004 - "cyproterone acetate, chlormadinone acetate) have demonstrated efficacy in the treatment of women with acne, although comparisons between trials are difficult because of differing endpoints. " 01/01/2008 - "The aim of this open-label, prospective, single-centre, phase IV study was to investigate the effects of an oral contraceptive containing chlormadinone 2 mg and ethinylestradiol 0.03 mg (Belara) on the physiology of acne-prone facial skin in healthy women aged 18-37 years. "
2.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/01/2013 - "The effects of chlormadinone acetate on lower urinary tract symptoms and erectile functions of patients with benign prostatic hyperplasia: a prospective multicenter clinical study." 08/01/2001 - "The effect of chlormadinone acetate (CMA), a synthetic steroidal antiandrogen, on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. " 08/01/2001 - "The effects of chlormadinone acetate (CMA), antiandrogen, on the pituitary, testis, prostate and adrenal gland of the dog with spontaneous benign prostatic hyperplasia." 07/01/2001 - "The effect of a synthetic steroidal antiandrogen, chlormadinone acetate (CMA), on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. " 08/01/2000 - "The atrophic effect of a synthetic steroidal antiandrogen, chlormadinone acetate (CMA), on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2013 - "To investigate the clinical efficacy of low-dose chlormadinone acetate (CMA) in prostate cancer patients who suffer from hot flushes that is a major side effect of androgen deprivation therapy. " 01/01/1999 - "To determine the efficacy of the antiandrogen chlormadinone acetate as a treatment option for stage A prostate cancer, a retrospective analysis of 111 patients who received chlormadinone acetate was done. " 04/01/2009 - "We prospectively studied the usefulness of chlormadinone acetate (CMA) as an alternative therapy for prostate cancer relapse after combined androgen blockade (CAB) therapy. " 04/01/2009 - "[Clinical usefulness of chlormadinone acetate as an alternative antiandrogen therapy for prostate cancer relapse after combined androgen blockade therapy]." 08/01/1995 - "Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer."
4.	Carcinoma (Carcinomatosis) 10/01/1987 - "Chlormadinone acetate, a progestational agent, has proved more effective against early prostatic carcinoma than against late-stage disease. " 09/01/1980 - "[The clinical effect of chlormadinone acetate on carcinoma of the prostate (author's transl)]." 08/01/1989 - "Two patients with focal and moderately differentiated carcinoma (stage A2) and three patients with stage A1 cancer were treated by means of chlormadinone acetate. " 01/01/1981 - "Based on the results obtained from animal experiments and from a pilot clinical trial on prostatic cancer patients using various antiandrogenic compounds, chlormadinone acetate (CMA) was selected for a clinical trial in patients with carcinoma of the prostate. " 01/01/1995 - "We investigated the efficacy of 2-week and 4-week pretreatments with 100 mg/day chlormadinone acetate (CMA) to prevent the flare reaction induced by luteinizing-hormone-releasing hormone (LHRH) in patients with metastatic carcinoma of the prostate. "
5.	Neoplasm Metastasis (Metastasis) 10/01/1994 - "By administering chlormadinone acetate for prostatic hypertrophy, the pulmonary metastases improved dramatically. " 10/01/1973 - " Of 22 nodules from the chlormadinone-treated dogs 12 were nodular hyperplasia, 4 benign mixed mammary tumors, 1 chondromucoid degeneration and 1 adenocarcinoma with widespread metastases. "

Related Drugs and Biologics

1.	Cyproterone Acetate
2.	Levonorgestrel (Plan B)
3.	Allylestrenol
4.	Gonadotropin-Releasing Hormone (GnRH)
5.	Flutamide (Eulexin)
6.	tamsulosin (Flomax)
7.	Adrenocorticotropic Hormone (ACTH)
8.	Ethinyl Estradiol (Estinyl)
9.	bicalutamide (Casodex)
10.	Belara

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Intrauterine Devices (Intrauterine Device)
3.	Castration
4.	Contraception (Birth Control)
5.	Prostatectomy (Retropubic Prostatectomy)