Chlordan (Chlordane)

A highly poisonous organochlorine insecticide. The EPA has cancelled registrations of pesticides containing this compound with the exception of its use through subsurface ground insertion for termite control and the dipping of roots or tops of non-food plants. (From Merck Index, 11th ed)

Also Known As:

Networked: 124 relevant articles (0 outcomes, 19 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sandler, Dale P: 4 articles (01/2018 - 02/2010)
2.	Engel, Lawrence S: 3 articles (11/2019 - 02/2016)
3.	Goldner, Whitney S: 3 articles (01/2018 - 02/2010)
4.	Kamel, Freya: 3 articles (01/2018 - 02/2010)
5.	Lerro, Catherine C: 3 articles (01/2018 - 01/2017)
6.	Ward, Mary H: 3 articles (01/2018 - 06/2009)
7.	Hoppin, Jane A: 3 articles (10/2013 - 02/2007)
8.	Grimsrud, Tom K: 2 articles (11/2019 - 01/2018)
9.	Rothman, Nathaniel: 2 articles (11/2019 - 02/2003)
10.	Beane Freeman, Laura E: 2 articles (01/2018 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2010 - "Cancer and chlordane-treated homes: a pinch of prevention is worth a pound of cure." 01/01/2005 - "Methods of gene array data analysis were also applied for discovery of genes involved in the regression of mouse liver tumors induced by chlordane, a nongenotoxic murine hepatocarcinogen. " 11/01/1995 - "In conclusion, chlordane induced liver tumors in both B6C3F1 and B6D2F1 male mice by mechanisms independent of ras oncogene activation and 30% of both benign and malignant liver tumors in the B6C3F1 mice regressed after exposure was discontinued." 11/01/1995 - "When chlordane exposure was discontinued for a group of B6C3F1 mice ('stop' group) at 491 days of age, overall tumor multiplicity significantly decreased by 30% from an average of 4.4 per tumor-bearing-animal at 525 days to 3.1 at terminal killing (568 days). " 11/01/1995 - "In order to determine if ras oncogene activation plays a role in the carcinogenicity of chlordane and whether the activation is dependent on genetic background, liver tumors from chlordane-treated B6C3F1 and B6D2F1 mice were analyzed for the presence of activating mutations in the ras oncogene. "
2.	Body Weight (Weight, Body) 08/01/1994 - "Female mice were treated with either 0 or 8 mg of chlordane per kilogram body weight daily for 18 days during pregnancy. " 05/01/1990 - "Female mice were treated with either 0, 4, or 8 mg of chlordane per kilogram body weight daily for 18 days during pregnancy. " 01/01/1977 - "Body weights of mice given either low or high doses showed little or no effect of the chlordane; however, other adverse clinical signs were seen with greater frequency than in control mice. " 01/01/1977 - "The effects of chlordane on body weights and other clinical signs in rats and mice indicated that the dosages used were near the maximum permissible. " 12/01/2000 - "In this study, rats were administered cis-nonachlor, trans-nonachlor, or technical chlordane by gavage for 28 days at doses of 0.25 to 25 mg/kg body weight. "
3.	Human Influenza (Influenza) 01/01/1985 - "Viral adsorption studies carried out at 4 and 37 degrees C on cells chronically exposed to 10 ppm chlordane revealed a decrease in the adsorption of influenza type A virus. " 01/01/1985 - "Viral inactivation studies carried out at 4 and 37 degrees C failed to reveal differences in the level of influenza type A virus inactivation in the presence or absence of chlordane. " 01/01/1985 - "Viral adsorption studies at 4 and 37 degrees C revealed a marked reduction in the attachment of influenza type A virus to both cell lines following acute exposure to 10 ppm chlordane. " 03/01/1990 - "It has been reported previously that BALB/c mice, treated in utero with chlordane, showed increased survival to influenza A/PR/8/34 [H1N1] (influenza) virus as young adults. " 06/01/1985 - "The effect of prenatal chlordane exposure on specific anti-influenza cell-mediated immunity."
4.	Infections 05/01/1985 - "Previous studies in our laboratory have indicated that in utero chlordane exposure caused a significant enhancement in the survival of the offspring to influenza virus infection. " 05/01/1985 - "The significant depression of the DTH and MLR responses supports our previous reports of enhanced survival of influenza virus infection following in utero exposure to chlordane, since active DTH contributes to the pathology of influenza virus infection in mice. " 03/01/1997 - "Immunosuppressive effects of low-level exposure to organochlorines, including chlordane and endosulfan, could be involved in the pathogenesis of the observed infections." 01/01/1985 - "Our findings indicate that chlordane alters the susceptibility of cells to infection with influenza type A virus but not to herpes simplex type 1 virus." 01/01/1985 - "The effect of chlordane on the susceptibility of Madin-Darby canine kidney cells and African Green monkey kidney cells to infection with influenza type A/PR/8/34 (HON1) virus and herpes simplex type 1 virus was determined. "
5.	Contact Dermatitis (Eczema, Contact) 11/15/1995 - "In the current study, chlordane was applied topically and the effects of oxazolone-induced contact hypersensitivity were determined. " 11/15/1995 - "Topical exposure to chlordane reduces the contact hypersensitivity response to oxazolone in BALB/c mice." 01/01/1990 - "Examples of incidents that have signaled a problem and resulting research projects are: 1) anaphylactic cardiovascular response to red imported fire ant venom (statewide morbidity survey); (2) unexplained contact dermatitis in tomato harvesters and floral designers (immunodermatologic study and statewide survey of florists); (3) concerns over two unexplained cancer deaths at an experimental agricultural research station (farmer's mortality study); (4) a household outbreak of organophosphate poisoning (statewide hospital morbidity survey); and (5) a woman in early pregnancy exposed to misapplication of chlordane in her house (literature review and update on trends in U.S. "

Related Drugs and Biologics

1.	oxychlordane
2.	nonachlor
3.	Heptachlor
4.	Insecticides
5.	Dichlorodiphenyl Dichloroethylene (DDE)
6.	DDT
7.	Polychlorinated Biphenyls (PCBs)
8.	Chlorinated Hydrocarbons
9.	Chlordan (Chlordane)
10.	Carcinogens

Related Therapies and Procedures

1.	Gynecologic Surgical Procedures (Gynecologic Surgery)
2.	General Anesthesia