Chlorates

11/01/1981 - "During the first hours, 70 mmol chlorate were excreted before complete renal failure occurred which required haemodialysis for several weeks. "
09/01/2000 - "It is recommended that the infusion dosage of olprinone chlorate should be reduced when given to patients with renal failure even if treated with CVVHDF."
11/12/1993 - "Intoxications with chlorate salts are characterized by methaemoglobin formation, haemolysis and renal insufficiency. "
09/01/2000 - "The study objective was to determine whether a phosphodiesterase III inhibitor, olprinone chlorate, is effectively removed by continuous venovenous hemodiafiltration (CVVHDF) in a patient with cardiac and renal failure. "
03/01/1984 - "Several other effects were observed that explain the clinical picture of chlorate poisoning which involves haemolysis followed by disseminated intravascular coagulation and renal failure: increased permeability to cations, increased resistance to hypotonic haemolysis and prolonged filtration time through polycarbonate membranes with cylindrical pores of 5 micron diameter. "

08/01/2010 - "Furthermore, the mechanism by which chlorate hydrate inhibits inflammation was associated with an attenuated increase in nuclear factor kappaB (NF-kappaB) activity in NF-kappaB-RE-luc mice upon LPS/D-GalN treatment. "
05/25/2010 - "Furthermore, the mechanism by which chlorate hydrate inhibits inflammation was associated with an attenuated increase in nuclear factor kappaappaB (NF-kappaB) activity in NF-kappaB-RE-luc mice upon LPS/D-GalN treatment. "
10/01/2002 - "In the current study, we demonstrated that chlorate, a specific inhibitor for PAPS synthesis, significantly suppressed production of sulfite by activated neutrophils obtained from rat peritoneal cavity that had been injected with glycogen to induce inflammation. "

02/01/2013 - "Severe chlorate poisoning successfully treated with methylene blue."
07/01/2011 - "We concluded that the cause of death was presumably due to chlorate poisoning, based on the results of the autopsy and the toxicological examination."
10/01/2007 - "Chlorate poisoning in beef cattle."
03/01/2000 - "A fatal case of chlorate poisoning: confirmation by ion chromatography of body fluids."
11/12/1993 - "Chlorate poisoning: mechanism of toxicity."

09/01/2014 - "Twelve lactating crossed Pelibuey and Blackbelly-Dorper ewes (average body weight, 65 kg) were randomly assigned (four per treatment) to receive a control treatment (TC; consisting of 3 g of NaCl per animal per day) or one of two chlorate treatments (T3 or T9; consisting of 1.8 or 5.4 g of NaClO3 per animal per day, respectively). "
06/01/2005 - "Heifers (n=64) were fed chlorate at either 0.01% or 0.05% of body weight (BW) in the last feeding or 0.01% for the last 5d before harvest, while control cattle received no chlorate. "
08/01/2007 - "Six Loala cattle were assigned (one heifer and one steer per treatment) to one of three intraruminal doses of radiolabeled sodium [36Cl]chlorate (21, 42, or 63 mg/kg body weight) administered in four equal aliquots over a 24-h period. "
03/07/2007 - "To determine the metabolism and disposition of the active ingredient in ECP, four male Sprague-Dawley (approximately 350 g) rats received a single oral dose of sodium [36Cl]chlorate (3.0 mg/kg body weight). "
09/07/2005 - "Three sets of cattle, each consisting of a heifer and a steer, were intraruminally dosed with a total of 21, 42, or 63 mg of sodium [36Cl]chlorate/kg of body weight. "

01/01/2018 - "We tested the antibacterial properties of chlorate against Pseudomonas aeruginosa, a pathogen that can inhabit hypoxic or anoxic microenvironments, including those that arise in human infection. "
01/01/2018 - "Here, we demonstrate the antibacterial activity of chlorate against Pseudomonas aeruginosa, a representative pathogen that can inhabit hypoxic or anoxic host microenvironments during infection. "
08/01/2007 - "Chlorate treatment, topical disinfection, and younger weaning age may be useful tools for reducing Salmonella shedding on farms that practice segregated weaning and where sow-to-piglet transfer of Salmonella is an important source of infection in nursery pigs."
01/01/2018 - "aeruginosa infections and are known to withstand conventional antibiotic treatment, are hypersensitive to chlorate. "
02/01/2007 - "Nitroethane inhibits the growth of certain zoonotic pathogens such as Campylobacter and Salmonella spp., foodborne pathogens estimated to cause millions of human infections each year, and enhances the Salmonella- and Escherichia coli-killing effect of an experimental chlorate product being developed as a feed additive to kill these bacteria immediately pre-harvest. "