Chloralose

A derivative of CHLORAL HYDRATE that was used as a sedative but has been replaced by safer and more effective drugs. Its most common use is as a general anesthetic in animal experiments.

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Networked: 568 relevant articles (5 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Roppolo, James R: 5 articles (04/2015 - 11/2004)
2.	Tai, Changfeng: 5 articles (04/2015 - 11/2004)
3.	de Groat, William C: 5 articles (04/2015 - 11/2004)
4.	Krylatov, A V: 5 articles (04/2009 - 06/2001)
5.	Maslov, L N: 5 articles (04/2009 - 06/2001)
6.	Solomon, Irene C: 5 articles (03/2005 - 03/2002)
7.	Kenney, M J: 4 articles (10/2003 - 06/2001)
8.	Wang, Jicheng: 3 articles (04/2015 - 09/2014)
9.	Xiao, Zhiying: 3 articles (04/2015 - 09/2014)
10.	Rogers, Marc J: 3 articles (04/2015 - 09/2014)

Related Diseases

1.	Hypotension (Low Blood Pressure) 01/01/1985 - "The present study was designed to determine effect of the preganglionic splanchnic nerve activity (SNA) on the brief hypotension accompanied with the occlusion of left circumflex coronary artery (CxCAO) in chloralose anesthetized cats. " 11/01/1979 - "A neuropathological examination was made of 15 cats anesthetized with alpha-chloralose, subjected to a stepwise reduction in mean arterial pressure by graded hemorrhagic hypotension. " 11/01/1979 - "The effects of graded hemorrhagic hypotension on electrocortical function was investigated in 12 cats anesthetized with alpha-chloralose. " 05/01/1982 - "The effect of baroreceptor reflex stimulation by carotid sinus hypotension on the pulmonary vascular response to atelectasis was studied in eight dogs anesthetized with chloralose. " 02/01/1994 - "We studied the cerebral blood flow and metabolic response of chloralose and urethane anesthetized newborn lambs to regulated hypotension. "
2.	Body Weight (Weight, Body) 07/01/1979 - "A heavy and two light strains of pullets suffered a decline in egg production but an improvement in body weight gains when alpha-chloralose, a tranquilizer, was included in their diets at .1 to .3%. " 09/01/1990 - "To determine whether atrial size may influence atrial receptor discharge, a group of cats and two groups of dogs with different body weights were examined under anaesthesia with alpha-chloralose. " 12/01/1977 - "Water diuresis was induced in dogs, under chloralose anesthesia, by hypotonic volume expansion of 5 to 10% body weight. " 02/01/1988 - "We determined the ventricular fibrillation threshold (VFT) changes in response to graded coronary sinus (CS) obstruction in 13 chloralose-anesthetized dogs with fixed heart rate (150 min-1, mean systemic arterial pressure (80 mm Hg), and cardiac index (100 ml/min.kg-1 body weight). " 11/01/1992 - "2. In mongrel, chloralose-urethane anaesthetized open-chest dogs, within a restricted body weight range, two 5 min periods of occlusion of the anterior descending branch of the left coronary artery markedly reduced the severity of the early ischaemic arrhythmias resulting from a prolonged (25 min) occlusion of the same coronary artery starting 20 min later. "
3.	Anoxia (Hypoxia) 04/01/1989 - "Our data suggest that chloralose-induced alterations in basal hemodynamics and in cardiovascular responses to alveolar hypoxia represent an uncontrolled variable in acute experimental studies. " 01/15/2009 - "In chloralose-anaesthetized, ventilated, vagotomized rats, acute hypoxia (10% O2, 60 s) evoked an increase in SNA (103 +/- 12%) that was characterized by a decrease in activity during early inspiration followed by a prominent rise during expiration. " 11/01/2000 - "Graded asymmetric spin echo-echo planar imaging (ASE-EPI) was used to measure transient alterations in cerebral oxygenation resulting from 60 seconds of anoxia in alpha-chloralose anaesthetised rats. " 06/01/1996 - "In peripherally chemodenervated, vagotomized, chloralose-anesthetized cats, hypoxia can produce central cardiorespiratory depression or excitation depending on severity. " 11/01/1991 - "We assessed the presence of an alpha 1-adrenoceptor-mediated coronary vasoconstrictor reflex response during acute systemic hypoxia in eight chloralose-anesthetized dogs. "
4.	Bradycardia 06/01/1980 - "alpha-Chloralose alone produced a significant SAP decrease in both SH and NT rats and bradycardia in SH but no significant HR change in NT rats. " 10/01/1979 - "In this investigation of medullary pathways mediating reflex vagal bradycardia to stimulation of buffer nerves, four series of experiments were done in 37 cats anesthetized with chloralose, paralyzed and artificially ventilated. " 05/01/1975 - "Stimulation of the central, basal, and lateral nuclei under chloralose elicited bradycardia. " 06/01/1966 - "In cats anaesthetized with chloralose, increased coronary artery pressure caused a reflex bradycardia without any primary change in sympathetic activity.3. The afferent fibres of the coronary depressor reflex are in the vagus nerves. " 09/01/1987 - "The effect of bilateral vagotomy and of vagal stimulation was studied, with and without attendant bradycardia, on the incidence of reperfusion arrhythmias in alpha-chloralose anesthetized cats. "
5.	Hypercapnia 08/17/2001 - "The effects of graded hypercapnia on the activation flow coupling response due to forepaw stimulation in alpha-chloralose anesthetized rats." 12/01/1999 - "The contribution of carotid chemoreceptors to hypercapnia-induced mesenteric venoconstriction was examined in 12 alpha-chloralose-anesthetized rabbits (1.0-1.6 kg). " 02/01/1994 - "Reduction of resting CBF (-50 +/- 4%; n = 6) by administration of chloralose (20-40 mg/kg i.v.) did not attenuate the CBF response to hypercapnia (P > 0.05). " 12/01/1988 - "Therefore, we determined the effects of acute and prolonged normoxic-hypercapnia on single fiber output of the carotid body of chloralose anesthetized goats. " 04/01/2001 - "We measured the field potential and the changes in local cerebral blood flow (LCBF) response during somatosensory activation (evoked LCBF) in alpha-chloralose--anesthetized rats by laser-Doppler flowmetry under normocapnia (PaCO(2)=34.3+/-3.8 mmHg) and hypercapnia (PaCO(2)=70.1+/-9.8 mmHg). "

Related Drugs and Biologics

1.	Urethane (Ethyl Carbamate)
2.	Serotonin (5 Hydroxytryptamine)
3.	Clonidine (ST 155)
4.	Carbon Monoxide
5.	Sodium Cyanide
6.	Muscimol
7.	sarpogrelate
8.	Pentobarbital (Nembutal)
9.	Morphine (MS Contin)
10.	Carbon Dioxide

Related Therapies and Procedures

1.	Injections
2.	Anesthesia
3.	Vagotomy
4.	Denervation
5.	Lasers (Laser)