Chloral Hydrate

09/01/1990 - "The study suggest that chloral hydrate is a safe and effective oral sedative but that children with neurologic disorders may need alternative drugs for sedation."

06/01/2013 - "The rats in SE group were treated with chloral hydrate to stop seizures after 60 min. Control animals were treated with the same dose of 0.9 % saline. "
03/01/2005 - "Audit of the use of chloral hydrate as an acute treatment for childhood seizures'."
11/01/2002 - "Seizures disappeared in the course of 24 hours after the launch of chloral hydrate therapy and have not recurred. "
11/01/1997 - "Seizures caused by chloral hydrate sedative doses."
10/01/1990 - "Chloral hydrate had no immediate effect in one case and only a doubtful influence on EEG seizure activity in another. "

05/01/2002 - "Nowadays should we be using chloral hydrate in cases of insomnia in adult and older people? "
01/01/1992 - "During their captivity the doctor prescribed them 4 g chloral hydrate per day because of insomnia. "
08/01/1961 - "A new tablet form of chloral hydrate (WM-1127) in the treatment of insomnia in the aged: double-blind study."
10/01/1991 - "A 42-year-old woman had an accidental overdose of chloral hydrate due to repeated absorption of a therapeutic dose of chloral syrup for insomnia. "
01/01/1980 - "Neither chloral hydrate not L-tryptophan had any significant side effects, but withdrawal of chloral hydrate was associated with insomnia."

03/19/2007 - "Focal ischemia was induced under chloral hydrate anaesthesia by unilateral permanent MCAo. "
08/01/2002 - "Carboxyfullerene was either intravenously (6 mg/kg) or intracerebroventricularly (0.1, 0.3 mg per rat) infused to the chloral hydrate-anesthetized Sprague-Dawley rats 30 min prior to transient ischemia-reperfusion. "
01/12/1998 - "CD-1 mice anesthetized by chloral hydrate were subjected to global ischemia by bilateral common carotid artery occlusion under controlled ventilation for 3, 5, and 10 min. After evaluating the patency of the posterior communicating artery (PcomA) as hypoplastic or normoplastic, neuronal injury was independently determined in the striatum, cortex, and hippocampus in each hemisphere. "
12/01/2003 - "Ischemia was induced in male Swiss mice, anaesthetized with chloral hydrate (400 mg/kg, i.p.), by a 15-min-occlusion of the left middle cerebral artery using an intraluminal suture. "
01/01/2012 - "Ischemia lasted for 30 min, followed by reperfusion for 360 min. Exhaled and blood pentane concentrations in the chloral hydrate group markedly increased 1 min after reperfusion and then decreased to baseline. "

01/01/1996 - "Whereas ingestion of 219 mg/kg of chloral hydrate resulted in transient bigeminy, ingestion of up to 960 mg/kg caused torsades de pointes and ventricular fibrillation which were effectively treated with defibrillation and a beta blocker. "
07/01/1986 - "Torsade de pointes: an unusual manifestation of chloral hydrate poisoning."