Chitinase

04/01/1997 - "Immunization of jirds with recombinant chitinase induced partial protection against microfilaremia resulting from subsequent infection with Brugia malayi, but did not reduce adult worm burdens. "
09/15/2015 - "In this study, the assay with the cyathostomins showed that chitinase had a nematocidal effect, suggesting that this enzyme acts on the "fungus versus nematodes" infection process. "
04/01/2014 - "The results presented in this study show that EpapGV chitinase overexpression in recombinant baculovirus can cause association of this protein with OBs, and suggest that this could be used to evaluate the protein role in early stages of baculoviral infections."
01/01/2012 - "The aim of this study was to determine the relationship between Chitinase 3-like 1 (CHI3L1), also known as YKL-40, a molecule associated with inflammatory processes, and schistosome infection, morbidity and systemic cytokine levels. "
03/01/2004 - "In the present study, we established a semi-quantitative method by Western blot analysis for measurement of the chitinase content in blood and examined its alteration during postnatal development and experimental infection with hemoprotozoan parasite in cattle. "

02/01/2012 - "This study examined whether plant chitinase III, using rZiz m 1-P and rZiz m 1-E, can stimulate allergic inflammation similar to that of mammalian chitinases. "
12/01/2015 - "YKL-40/chitinase-3-like-1 protein is often up-regulated in inflammation-associated diseases. "
08/01/2015 - "The inactive chitinase YKL-40 is expressed highly during inflammation and has been proposed as a marker of poor prognosis. "
06/01/2015 - "YKL-40/chitinase 3-like protein 1 is a novel biomarker of systemic inflammation. "
04/01/2015 - "YKL-40 is a chitinase-like protein that has a role in the inflammation and tissue remodeling in several human diseases. "

03/01/2014 - "In children with high preoperative circulating chitinase activity levels, asthma control and healthcare utilization were significantly improved after adenotonsillecotmy. "
03/01/2014 - "Higher chitinase activity levels at baseline were associated with improved asthma control following surgery (P < 0.01). "
08/01/2011 - "Studies regarding the physiological role of acidic mammalian chitinase (AMCase) and the effects of its genetic variants on asthma have produced conflicting results. "
05/01/2011 - "To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma. "
12/15/2005 - "Recent studies in mouse models of bronchial asthma have shown that acid mammalian chitinase (AMCase) is involved in the pathophysiology of asthma. "

09/01/2005 - "Injected chitinase destroyed the tumor tissue and cured the mice. "
02/01/2015 - "The prototypic chitinase-like protein Chi3l1 is induced in cancers and portends a poor prognosis, but whether it contributes to cancer progression is unknown. "
02/01/2015 - "Increasing evidence demonstrated that chitinase 3-like 1 (CHI3L1) was highly expressed and tightly associated with human tumor development and progression. "
01/01/2015 - "High Endogenous Expression of Chitinase 3-Like 1 and Excessive Epithelial Proliferation with Colonic Tumor Formation in MOLF/EiJ Mice."
12/01/2014 - "Increasing evidence demonstrated that Chitinase 3-like 1 (hereafter termed CHI3L1 or YKL-40) was highly expressed and tightly associated with human tumor development and progression. "

02/01/2008 - "Chitinase levels in the tears of subjects with ocular allergies."
03/01/2007 - "In addition, pan-chitinase inhibitor significantly ameliorates T helper-2-mediated inflammation and airway hypersensitivity. "
02/01/2011 - "Acidic mammalian chitinase (AMCase) has been found to play an important role in allergy and asthma. "
07/01/2009 - "Chitinases and chitinase-like proteins: potential therapeutic targets for the treatment of T-helper type 2 allergies."
06/01/2011 - "This review is based on the results of PubMed-searches using the search-terms: chitin, chitinase, allergy and asthma. "