Chitin

A linear polysaccharide of beta-1->4 linked units of ACETYLGLUCOSAMINE. It is the second most abundant biopolymer on earth, found especially in INSECTS and FUNGI. When deacetylated it is called CHITOSAN.

Networked: 492 relevant articles (14 outcomes, 44 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Samuelson, John: 9 articles (11/2015 - 06/2002)
2.	Jayakumar, R: 9 articles (03/2015 - 02/2010)
3.	Robbins, Phillips W: 8 articles (12/2013 - 06/2002)
4.	Elias, Jack A: 7 articles (03/2015 - 06/2004)
5.	Munro, Carol A: 6 articles (10/2015 - 10/2004)
6.	Gow, Neil A R: 6 articles (10/2015 - 10/2004)
7.	Ifuku, Shinsuke: 6 articles (06/2015 - 06/2012)
8.	Azuma, Kazuo: 6 articles (06/2015 - 09/2012)
9.	Okamoto, Yoshiharu: 6 articles (06/2015 - 09/2012)
10.	Osaki, Tomohiro: 6 articles (06/2015 - 09/2012)

Related Diseases

1.	Infection 08/01/1995 - "This method of chitin determination may be a useful alternative method for future investigations involving the study of fungal infections in mammalian tissues." 12/01/2015 - "Effects of dietary administration of Bacillus subtilis FPTB13 and chitin, single or combined, on the systemic immunity, mucosal immunity and resistance of catla (Catla catla) against Edwardsiella tarda infection were investigated. " 10/01/2015 - "Chitin-rich cells may, therefore, persist in human tissues and act as the focus for breakthrough infections. " 06/01/2015 - "Chitin, a key factor in immune regulation: lesson from infection with fungi and chitin bearing parasites." 03/31/2015 - "The released monooxygenase domain is then free to disrupt the chitin-rich peritrophic matrix that protects insects against oral infections. "
2.	Wounds and Injuries (Trauma) 01/01/2012 - "The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. " 12/01/2008 - "The study shows the chitin dressings as useful adjunct in wound care." 01/01/2008 - "The results of this clinical study confirm that chitin nanofibrils-based gel promotes rapid and physiological healing of different types of wounds. " 08/01/2003 - "Flexible chitin films as potential wound-dressing materials: wound model studies." 06/05/2015 - "The data indicated that SDACNFs effectively induced the proliferation and re-modeling phases compared with chitin, CNFs, and CSNFs in the wound. "
3.	Hypersensitivity (Allergy) 10/01/2007 - "A recent intriguing study has highlighted the role of chitin in allergic reactions." 08/01/2015 - "Furthermore, cell wall integrity (CWI) was largely affected by deletion of SAC1, due to the hypersensitivity to cell wall stress, changed content and distribution of chitin in the mutant. " 05/01/2014 - "Cells of the innate immune system that are implicated in allergy and immunity bind to chitin during tissue infiltration in a process negatively regulated by vertebrate chitinases. " 01/01/2013 - "Thus, chitin induces the generation of C3a in the lung, and chitin-dependent allergic sensitization to Aspergillus requires C3aR signaling, which suppresses regulatory dendritic cells and T cells and induces allergy-promoting T cells." 05/01/2012 - "Chitin is a recognition element for tissue infiltration by innate cells implicated in allergy and immunity. "
4.	Polycystic Kidney Diseases (Polycystic Kidney Disease) 06/01/2003 - "The depolymerases were modular in nature and contained glycosyl hydrolase family 18 domains, chitin-binding domains, and polycystic kidney disease domains. " 01/01/2015 - "We improved catalytic efficiency of SpChiD in degradation of insoluble chitin substrates by fusing with auxiliary domains like polycystic kidney disease (PKD) domain and chitin binding protein 21 (CBP21). " 01/01/2005 - "The aim of study was to clarify whether the polycystic kidney disease (PKD) domain of chitinase A (ChiA) participates in the hydrolysis of powdered chitin. " 12/01/2005 - "Homology modelling of the chitinase of Epiphyas postvittana nucleopolyhedrovirus (EppoNPV) against Serratia marcescens chitinase A indicated that the enzyme possesses an N-terminal polycystic kidney 1 (PKD1) domain for chitin-substrate feeding and an alpha/beta TIM barrel catalytic domain characteristic of a family 18 glycohydrolase. " 01/01/2005 - "Role of the N-terminal polycystic kidney disease domain in chitin degradation by chitinase A from a marine bacterium, Alteromonas sp. strain O-7."
5.	Eosinophilia 08/01/2014 - "We observed that repeated aspirations of the high-chitin-expressing isolate Af5517 induced increased airway eosinophilia in the lungs of recipient mice compared to the level of eosinophilia induced by isolate Af293. " 09/01/2012 - "Chitin exposure in the lung induces eosinophilia and alternative activation of macrophages and is correlated with allergic airway disease. " 07/01/2011 - "Our results indicate that the effects of chitin in vivo are highly dependent on particle size and that large, nonphagocytosable beads, independent of their chemical composition, induce innate eosinophilia and activate Mϕ expressing several M2, but not M1, phenotypes." 07/01/2011 - "Chitin particles induce size-dependent but carbohydrate-independent innate eosinophilia." 04/01/2014 - "Fungal chitin also induced eosinophilia in vivo, underpinning its ability to induce asthma. "

Related Drugs and Biologics

1.	Chitosan
2.	Glucosamine (Dona)
3.	Carrier Proteins (Binding Protein)
4.	Immunoglobulin E (IgE)
5.	Collagen
6.	Cytokines
7.	Nitrogen
8.	fluphenacur (lufenuron)
9.	Interleukin-12 (IL 12)
10.	Ligases

Related Therapies and Procedures

1.	Oral Administration
2.	Intranasal Administration
3.	Microspheres (Microsphere)
4.	Drug Therapy (Chemotherapy)
5.	Catheters